- Home
- Publications
- Publication Search
- Publication Details
Title
Current development of CBP/p300 inhibitors in the last decade
Authors
Keywords
CBP/p300, Bromodomain, HAT, Inhibitors
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 209, Issue -, Pages 112861
Publisher
Elsevier BV
Online
2020-10-01
DOI
10.1016/j.ejmech.2020.112861
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors
- (2020) Yaxi Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs
- (2020) Paula Katavolos et al. TOXICOLOGIC PATHOLOGY
- A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL
- (2020) Baojie Zhang et al. BIOCHEMICAL PHARMACOLOGY
- Early Drug Discovery Efforts Towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors
- (2020) Jonathan Edward Wilson et al. ChemMedChem
- Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP
- (2020) Fangrui Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor
- (2020) Jonathan E. Wilson et al. ACS Medicinal Chemistry Letters
- Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
- (2020) Yu Chen et al. BIOORGANIC CHEMISTRY
- Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer
- (2019) Ling-jiao Zou et al. ACTA PHARMACOLOGICA SINICA
- Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
- (2019) Ayyub Ebrahimi et al. Nature Chemical Biology
- Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
- (2019) Feng-cai Zhang et al. ACTA PHARMACOLOGICA SINICA
- Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors
- (2019) Ruiqi Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300
- (2018) Kwong Wah Lai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and optimization of 1-(1 H -indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer
- (2018) Qiuping Xiang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Total Synthesis and Evaluation of B-Homo Palmatine and Berberine Derivatives as p300 Histone Acetyltransferase Inhibitors
- (2018) Zhongzhen Yang et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Structural dynamics and quantum mechanical aspects of shikonin derivatives as CREBBP bromodomain inhibitors
- (2018) Sarmistha Mitra et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
- (2018) Michael R. Michaelides et al. ACS Medicinal Chemistry Letters
- Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors
- (2018) Wenchao Lu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP
- (2018) Rui Wang et al. MOLECULAR CANCER THERAPEUTICS
- CBP/p300 inhibitor C646 prevents high glucose exposure induced neuroepithelial cell proliferation
- (2018) Baoling Bai et al. Birth Defects Research
- Discovery of selective inhibitors for cyclic AMP response element-binding protein
- (2018) Iqra Muneer et al. ANTI-CANCER DRUGS
- A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
- (2017) Sarah M. Bronner et al. JOURNAL OF MEDICINAL CHEMISTRY
- GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
- (2017) F. Anthony Romero et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain
- (2017) R. Aldrin Denny et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
- (2017) Loren M. Lasko et al. NATURE
- The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
- (2016) Thea van den Bosch et al. BIOCHEMICAL PHARMACOLOGY
- Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112
- (2016) Beth E. Zucconi et al. BIOCHEMISTRY
- Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300
- (2016) H. Jane Dyson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition
- (2016) Srimoyee Ghosh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300
- (2016) Terry D. Crawford et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors
- (2016) Tobias A. Popp et al. JOURNAL OF MEDICINAL CHEMISTRY
- CBP/p300 acetyltransferase activity in hematologic malignancies
- (2016) Ritika Dutta et al. MOLECULAR GENETICS AND METABOLISM
- An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells
- (2016) Meng-Li Gu et al. ONCOLOGY REPORTS
- Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
- (2016) Alexander M. Taylor et al. ACS Medicinal Chemistry Letters
- Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method
- (2016) Guo-Bo Li et al. RSC Advances
- Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
- (2015) S. Picaud et al. CANCER RESEARCH
- Protein Lysine Acetylation by p300/CBP
- (2015) Beverley M. Dancy et al. CHEMICAL REVIEWS
- Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities
- (2015) Eugene L. Piatnitski Chekler et al. CHEMISTRY & BIOLOGY
- Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization
- (2015) Lele Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach
- (2015) Ciro Milite et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain
- (2015) Andrea Unzue et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics
- (2015) Min Xu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors
- (2015) F. Anthony Romero et al. JOURNAL OF MEDICINAL CHEMISTRY
- CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
- (2015) Ariane Hammitzsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300
- (2015) Jonathan H. Shrimp et al. ACS Medicinal Chemistry Letters
- Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo
- (2015) J M Gajer et al. Oncogenesis
- A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction
- (2014) Timothy P. C. Rooney et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
- (2014) Jian Zhong et al. CANCER RESEARCH
- Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- (2014) F Pietrocola et al. CELL DEATH AND DIFFERENTIATION
- Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells
- (2014) Alessia Lenoci et al. ChemMedChem
- Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
- (2014) Duncan A. Hay et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)
- (2014) S. D. Furdas et al. MedChemComm
- Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition
- (2013) Feng Wang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
- (2013) H. Yang et al. MOLECULAR CANCER THERAPEUTICS
- Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation
- (2013) Manuela Delvecchio et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition
- (2012) Beverley M. Dancy et al. CHEMBIOCHEM
- Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites
- (2012) Lewis R. Vidler et al. JOURNAL OF MEDICINAL CHEMISTRY
- Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions
- (2012) David S. Hewings et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prodrug Strategies in Ocular Drug Delivery
- (2012) Megha Barot et al. Medicinal Chemistry
- Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ12-PGJ2 through Covalent Binding to Cys1438
- (2011) Kodihalli C. Ravindra et al. CHEMICAL RESEARCH IN TOXICOLOGY
- A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes
- (2011) Jagat C. Borah et al. CHEMISTRY & BIOLOGY
- Rational Design of Cyclic Peptide Modulators of the Transcriptional Coactivator CBP: A New Class of p53 Inhibitors
- (2011) Guillermo Gerona-Navarro et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- New Potent Bisubstrate Inhibitors of Histone Acetyltransferase p300: Design, Synthesis and Biological Evaluation
- (2010) Franciane Ho A Kwie et al. Chemical Biology & Drug Design
- Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor
- (2010) Erin M. Bowers et al. CHEMISTRY & BIOLOGY
- Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
- (2010) David C. Bedford et al. Epigenetics
- Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
- (2010) Chia-Hsin Chan et al. NATURE CELL BIOLOGY
- Transcriptional coactivators p300 and CBP stimulate estrogen receptor-beta signaling and regulate cellular events in prostate cancer
- (2010) Jan Bouchal et al. PROSTATE
- Histone acetyl transferases as emerging drug targets
- (2009) Frank J. Dekker et al. DRUG DISCOVERY TODAY
- Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function
- (2008) Ling Wang et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
- (2008) Xin Liu et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now