α-Ketoglutarate links p53 to cell fate during tumour suppression

Metabolic regulation of chromatin modifications and gene expression

(2018) Juan Manuel Schvartzman et al.   JOURNAL OF CELL BIOLOGY

Optimized base editors enable efficient editing in cells, organoids and mice

(2018) Maria Paz Zafra et al.   NATURE BIOTECHNOLOGY

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

(2017) Waki Hosoda et al.   JOURNAL OF PATHOLOGY

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling

(2015) Kristofer Davie et al.   PLoS Genetics

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

A modular and flexible ESC-based mouse model of pancreatic cancer

(2014) M. Saborowski et al.   GENES & DEVELOPMENT

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

(2014) Lukas E. Dow et al.   PLoS One

Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation

(2014) John P. Morris et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

(2013) C. Chen et al.   GENES & DEVELOPMENT

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

IsoCor: correcting MS data in isotope labeling experiments

(2012) P. Millard et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective activation of p53-mediated tumour suppression in high-grade tumours

(2010) Melissa R. Junttila et al.   NATURE

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

(2008) A. B. Martinez-Cruz et al.   CANCER RESEARCH

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE