The Role of NLRP3 Inflammasome in Lupus Nephritis

Bite of the wolf: innate immune responses propagate autoimmunity in lupus

(2021) Sarthak Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Three functional variants in the NLRP3 gene are associated with susceptibility and clinical characteristics of systemic lupus erythematosus

(2021) Naeim Ehtesham et al.   LUPUS

Differential expression of the inflammasome complex genes in systemic lupus erythematosus

(2020) Heidi Lacerda Alves da Cruz et al.   IMMUNOGENETICS

Tris DBA Ameliorates Accelerated and Severe Lupus Nephritis in Mice by Activating Regulatory T Cells and Autophagy and Inhibiting the NLRP3 Inflammasome

(2020) Chung-Yao Wu et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation in podocytes: a new mechanism of glomerular diseases

(2020) Wei Xiong et al.   INFLAMMATION RESEARCH

Role of the NLRP3 inflammasome in autoimmune diseases

(2020) Zhe Li et al.   BIOMEDICINE & PHARMACOTHERAPY

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

(2020) Jinwen Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 polymorphisms with systemic lupus erythematosus disease activity and biomarker levels

(2020) Zhenzhen Su et al.   MEDICINE

Pim-1 as a therapeutic target in human lupus nephritis

(2019) Rong Fu et al.   Arthritis & Rheumatology

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation

(2019) Chaohuan Guo et al.   JOURNAL OF AUTOIMMUNITY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis

(2019) Francesca Bonomini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis

(2019) Luo-Yi Wang et al.   Journal of Translational Medicine

Accelerated and Severe Lupus Nephritis Benefits From M1, an Active Metabolite of Ginsenoside, by Regulating NLRP3 Inflammasome and T Cell Functions in Mice

(2019) Tsai-Jung Lin et al.   Frontiers in Immunology

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation

(2019) CongXiao Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

Niclosamide ethanolamine improves kidney injury in db/db mice

(2018) Pengxun Han et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2018) Wu Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus

(2018) Zhen-Zhen Ma et al.   Journal of Inflammation-London

Lentivirus-mediated knockdown of FcγRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice

(2018) Hongfeng Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

(2018) Congfei Xu et al.   Nature Communications

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

(2017) Honglei Guo et al.   MEDIATORS OF INFLAMMATION

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus

(2016) Ailing Lu et al.   JOURNAL OF IMMUNOLOGY

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells

(2016) Neil E. Kay et al.   LEUKEMIA & LYMPHOMA

Association between functional NLRP3 polymorphisms and susceptibility to autoimmune and inflammatory diseases: a meta-analysis

(2016) Y H Lee et al.   LUPUS

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

The frequency and outcome of lupus nephritis: results from an international inception cohort study

(2015) John G. Hanly et al.   RHEUMATOLOGY

Murine and Human Lupus Nephritis: Pathogenic Mechanisms and Theoretical Strategies for Therapy

(2015) Hege Lynum Pedersen et al.   SEMINARS IN NEPHROLOGY

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

(2015) Shuk-Man Ka et al.   ARTHRITIS RESEARCH & THERAPY

Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury

(2015) Takanori Komada et al.   Scientific Reports

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling

(2014) Maciej Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

A ginseng saponin metabolite suppresses tumor necrosis factor-α-promoted metastasis by suppressing nuclear factor-κB signaling in murine colon cancer cells

(2014) Min-Kyung Choo et al.   ONCOLOGY REPORTS

Ginsenoside Metabolite Compound K Promotes Recovery of Dextran Sulfate Sodium-Induced Colitis and Inhibits Inflammatory Responses by Suppressing NF-κB Activation

(2014) Juan Li et al.   PLoS One

Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages

(2014) C.-A. Yang et al.   RHEUMATOLOGY

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

(2013) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus Erythematosus

(2013) Q. Yang et al.   JOURNAL OF RHEUMATOLOGY

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Impact of the Tumor Necrosis Factor Receptor-Associated Protein 1 (Trap1) on Renal DNaseI Shutdown and on Progression of Murine and Human Lupus Nephritis

(2012) Silje Fismen et al.   AMERICAN JOURNAL OF PATHOLOGY

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

(2012) Alessandra Pontillo et al.   AUTOIMMUNITY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice

(2012) Yue-Ming Shen et al.   DIGESTIVE DISEASES AND SCIENCES

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e

(2012) Dhivya Thiyagarajan et al.   PLoS One

The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1β and IL-18 Production

(2012) Deepti Verma et al.   PLoS One

Inhibition of Pim1 Kinase Activation Attenuates Allergen-Induced Airway Hyperresponsiveness and Inflammation

(2011) Yoo Seob Shin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Monocyte activation by apoptotic cells removal in systemic lupus erythematosus patients

(2010) Lina M. Yassin et al.   CELLULAR IMMUNOLOGY

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma

(2009) Yuki Hitomi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

(2009) H. Li et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

(2008) Padmalatha S Reddy et al.   ARTHRITIS RESEARCH & THERAPY