Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
Farnaz Khalili, Asad Vaisi-Raygani, Ebrahim Shakiba, Maryam Kohsari, Maryam Dehbani, Rozita Naseri, Soheila Asadi, Ziba Rahimi, Mehrali Rahimi, Zohreh Rahimi
Summary: Chronic hyperglycemia leads to nerve tissue and retina damage through inflammatory pathways and oxidative stress mechanisms. The Keap1-Nrf2 pathway is an important antioxidant pathway affected by Keap1 variants, which may impact susceptibility to diabetes complications. In this study, patients with neuropathy had lower antioxidant levels and higher oxidative stress compared to those without complications, suggesting a role of reduced antioxidant system and Keap1 variants in the pathogenesis of diabetes and its complications. Monitoring oxidative stress parameters and using antioxidants in treatment of diabetic patients, especially those with complications, is recommended.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Jibo Han, Xiaowen Shi, Jiajun Xu, Wante Lin, Yanghao Chen, Bingjiang Han, Yi Wang, Jianjiang Xu
Summary: This study aims to evaluate the effect of NBP on atherosclerosis and explore its antioxidative mechanisms and targets. The results demonstrate that NBP has a therapeutic effect on the formation of atherosclerotic plaques and oxidative damage. Additionally, NBP may improve oxLDL-induced oxidative stress by influencing the Keap-1/Nrf-2 interaction.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Instruments & Instrumentation
Kopal Agarawal, Yogesh Anant Kulkarni, Sarika Wairkar
Summary: This review article focuses on the application of flavonoid nanoformulations in the treatment of diabetes, overcoming limitations by enhancing solubility, absorption, and therapeutic efficacy. These nanoformulations have the potential to be effective interventions for diabetes and its complications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Randa A. Zaghloul, Amr M. Abdelghany, Yara A. Samra
Summary: This study investigated the inhibitory effects of Rutin and Selenium nanoparticles on the Stat3 pathway in diabetic nephropathy. The results showed that the combination of Rutin and Selenium nanoparticles had a potential renoprotective effect. The study suggests that Rutin and Selenium nanoparticles may alleviate inflammation and kidney damage by modulating the Nrf-2/HO-1 and Jak-2/Stat3 pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengni Li, Rongping Fan, Xuemin Peng, Jiaojiao Huang, Huajie Zou, Xuefeng Yu, Yan Yang, Xiaoli Shi, DeLin Ma
Summary: This study found a close association between ANGPTL8, resistin, and DN in T2DM patients, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors for DN.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Yimeng Hu, Qinge Li, Rui Min, Yingfeng Deng, Yancheng Xu, Ling Gao
Summary: The study found that for patients with T2DM, elevated SUA concentration is an independent risk factor for the prevalence of NAFLD and DN, but not DR or DPN.
Article
Food Science & Technology
Tong Jin, Cheng Chen
Summary: The findings suggest that umbelliferone has a protective effect on diabetic nephropathy by activating the Nrf2/HO-1 pathway and attenuating high glucose-induced ferroptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Haidy Yosri, Dalia H. El-Kashef, Mohamed El-Sherbiny, Eman Said, Hatem A. Salem
Summary: In this study, the reno-protective effect of calycosin, an isoflavone found in Radix Astragali, was investigated in diabetic nephropathy. Calycosin improved kidney function, reduced inflammation and oxidative stress, and modulated NF-kappa B/p65/NLRP3/TXNIP signaling pathway, suggesting its potential as a promising drug for preventing the development of diabetic nephropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Xiaoyan Ren, Zhihui Zhang, Zhaoli Yan
Summary: The study conducted a meta-analysis on 9304 T2DM patients, finding that higher serum Lp(a) levels were associated with increased odds of diabetic nephropathy. Continuous variable analysis also showed a consistent increase in odds of diabetic nephropathy with each 1 mg/dl increment of Lp(a). Study characteristics did not significantly affect the association.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Manisha J. Oza, Ankit P. Laddha, Anil Bhanudas Gaikwad, Shrikant R. Mulay, Yogesh A. Kulkarni
Summary: Dietary modification plays a crucial role in managing diabetes and its complications by reprogramming nutrient intake and modulating molecular pathways related to autophagy, energy metabolism, and inflammation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Fukashi Ishibashi, Aiko Kosaka, Mitra Tavakoli
Summary: In patients with type 2 diabetes, the use of SGLT2 inhibitors can reduce glycemic variability and provide neurologic and renal protection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Melissa A. Elafros, Brian C. Callaghan, Lesli E. Skolarus, Loretta Vileikyte, John G. Lawrenson, Eva L. Feldman
Summary: Knowledge about microvascular complications of diabetes varies among patients and healthcare providers, with factors such as education level, disease duration, and socioeconomic status influencing patient knowledge. Misconceptions regarding appropriate screening practices for complications are common among healthcare providers. Further research is needed to identify interventions that can improve knowledge and outcomes for both patients and providers.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Genetics & Heredity
Ahmed Khattab, Ali Torkamani
Summary: This study investigates the genetic basis of diabetic kidney disease (DKD) in type 2 diabetes (T2D) using data from the UK Biobank. The results confirm two loci previously associated with chronic kidney disease and creatinine estimated glomerular filtration rate in T2D, and also identify a novel association between DKD and a variant rs72763500, which is a splicing quantitative trait locus for the nidogen-1 gene.
Review
Cell Biology
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A. Alhazmi, Simona Bungau
Summary: This review discusses the association of amyloid precursor protein, presenilin 1, amyloid beta, and GSK3 with Alzheimer's Disease (AD) and the impact of acetylcholinesterase on AD pathology. It highlights the significance of AChE inhibitors in AD therapeutics and the potential role of the AChE peptide variant NBP14 in mitigating neurodegeneration associated with AD.
AGEING RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Monica Foghis, Simona Gabriela Bungau, Alexa Florina Bungau, Cosmin Mihai Vesa, Anamaria Lavinia Purza, Alexandra Georgiana Tarce, Delia Mirela Tit, Annamaria Pallag, Tapan Behl, Syed Shams ul Hassan, Andrei-Flavius Radu
Summary: Hepatic disorders are significant health problems with high incidence and increased risk of chronicling or death. Many patients with chronic liver diseases use herbal medicines in parallel with allopathic treatment. This paper provides a thorough analysis of studies on medicinal plants, bioactive compounds, and the activity of herbal medicines in the evolution of chronic liver diseases. However, there is often a lack of comprehensive data on illness progression and patient living standards, which should be considered when evaluating the long-term effects of herbal treatments on the health and quality of life of individuals with liver disease. Bioactive phytocomponents may be a valuable source for developing novel medications, but further research is needed to assess safety, effectiveness, and standardization for therapeutic management of liver illnesses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Ruxandra-Cristina Marin, Simona Gabriela Bungau, Delia Mirela Tit, Paul Andrei Negru, Andrei-Flavius Radu, Radu Dumitru Moleriu
Summary: Approximately two-thirds of Romanian HIV patients were parenterally infected with the F subtype of HIV in early childhood. They are now facing immunological aging, with immunosuppression posing an additional challenge in developing effective and well-tolerated regimens. A retrospective study compared the immune recovery of 462 HIV-infected patients who received different treatment regimens, showing normal immune response but a significant difference between groups. The study also assessed the relationship between immune and virological responses to therapy, finding an association at the final visit.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Aditi Sharma, Tapan Behl, Lalit Sharma, Om Prakash Shah, Shivam Yadav, Monika Sachdeva, Summya Rashid, Simona Gabriela Bungau, Cristiana Bustea
Summary: Recently, there has been increasing focus on the chronic neuro-inflammatory condition causing neuropathic pain, characterized by thermal hyperalgesia and tactile allodynia, which results from injury or infection in the nervous system. Angiogenesis, chemokines, and cytokines play important roles in the pathophysiology of neuropathic pain, contributing to inflammation and detrimental effects. Various mechanisms, including VEGF signaling, Tie-1 and Tie-2 receptor signaling, and erythropoietin pathway promoting axonal growth, have been identified as potential targets for therapeutic interventions in neuropathic pain associated with angiogenesis. Synthetic and herbal treatments targeting angiogenesis in neuropathic pain have also been explored.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Cosmin Mihai Vesa, Simona Gabriela Bungau
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrei-Flavius Radu, Simona Gabriela Bungau, Andrei Paul Negru, Bogdan Uivaraseanu, Mihaela Alexandra Bogdan
Summary: Rheumatoid arthritis (RA) is a severe autoimmune disease that affects millions of patients worldwide. Despite recent improvements, there are still unmet needs in the treatment of RA. In this study, in silico research was conducted to identify potential active molecules for the treatment of RA. The findings suggest that further research is needed to validate the efficacy and safety profiles of the most promising candidates.
Review
Health Care Sciences & Services
Nicoleta Anamaria Pascalau, Andrei-Flavius Radu, Delia Carmen Nistor Cseppento, Felicia Liana Andronie-Cioara, Anamaria Jurcau, Calin Mos, Alexa Florina Bungau, Simona Gabriela Bungau
Summary: Lymphangioleiomyomatosis (LAM) is a rare disease characterized by cystic lung destruction and respiratory failure. There may be a potential association between LAM and rheumatoid arthritis (RA) due to similar pathophysiological mechanisms involving dysregulated immunological function and inflammation. Further research is necessary to understand the connection between these two disorders and develop new therapeutic options.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Florentina Mihaela Pancescu, Abbas Abdul Kadhim Klaif Rikabi, Ovidiu Cristian Oprea, Alexandra Raluca Grosu, Aurelia Cristina Nechifor, Vlad-Alexandru Grosu, Szidonia-Katalin Tanczos, Florina Dumitru, Gheorghe Nechifor, Simona Gabriela Bungau
Summary: This paper presents the preparation and characterization of composite membranes based on chitosan and sulfonated ethylene-propylene-diene terpolymer, and evaluates their performance in the controlled release of melatonin. The prepared membranes can release different amounts of melatonin in dedicated environments.
Review
Biology
Cristiana Bustea, Alexa Florina Bungau, Delia Mirela Tit, Diana Carina Iovanovici, Mirela Marioara Toma, Simona Gabriela Bungau, Andrei-Flavius Radu, Tapan Behl, Adrian Cote, Elena Emilia Babes
Summary: Left ventricular non-compaction (LVNC) is a rare disease characterized by a two-layered ventricular wall, and controversies still exist regarding its classification. This review analyzes the diagnosis, treatment, and prognosis of LVNC, as well as the current knowledge regarding reverse remodeling. A case study is presented to illustrate the effectiveness of angiotensin receptor neprilysin inhibitor in LVNC treatment. LVNC is a heterogeneous cardiomyopathy, and while favorable outcomes are not common, some patients respond well to therapy.
Article
Biology
Cristiana Bustea, Delia Mirela Tit, Alexa Florina Bungau, Simona Gabriela Bungau, Vlad Alin Pantea, Elena Emilia Babes, Larisa Renata Pantea-Rosan
Summary: Recurrent hospitalizations after ACS are common, and identifying the risk factors is crucial for management. The study found that complete revascularization and higher left ventricular ejection fraction were independent predictors of reduced readmissions in the first year after an acute coronary event.
Article
Biology
Andrei-Flavius Radu, Paul Andrei Negru, Ada Radu, Alexandra Georgiana Tarce, Simona Gabriela Bungau, Mihaela Alexandra Bogdan, Delia Mirela Tit, Bogdan Uivaraseanu
Summary: This study investigated the potential use of phytoconstituents from Embelia ribes as treatment agents for rheumatoid arthritis (RA) using in silico methodologies. Several compounds were identified with high binding affinities to target proteins involved in RA, suggesting their potential for future therapeutic development.
Article
Health Care Sciences & Services
Monica Foghis, Delia Mirela Tit, Simona Gabriela Bungau, Timea Claudia Ghitea, Csaba Robert Pallag, Andreea Monica Foghis, Tapan Behl, Cristian Bustea, Annamaria Pallag
Summary: Cross-sectional studies provide essential insights about public health through data and statistics. This study investigates the frequency and habits of hepatoprotective nutritional supplement consumption among patients with chronic diseases. The findings reveal that the majority of patients incorporate hepatoprotective supplements into their treatment, with women having a higher usage rate. Moreover, patients who integrate supplements into their daily routine tend to have better overall nutritional status.
Review
Medicine, General & Internal
Flaviu Bodea, Simona Gabriela Bungau, Mihaela Alexandra Bogdan, Cosmin Mihai Vesa, Ada Radu, Alexandra Georgiana Tarce, Anamaria Lavinia Purza, Delia Mirela Tit, Cristian Bustea, Andrei-Flavius Radu
Summary: Ocular diseases can have a significant impact on vision and quality of life. Micropulse laser therapy, compared to conventional laser techniques, offers advantages in minimizing collateral damage while effectively treating target tissues. Further research is needed to optimize treatment protocols, evaluate long-term efficacy, and explore the role of micropulse laser therapy in combination therapies.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, Research & Experimental
Alexandrina Fodor, Delia Carmen Nistor Cseppento, Gabriela Elena Badea, Anda Ioana Petrehele, Alina Groze, Delia Mirela Tit, Simona Gabriela Bungau
Summary: The study investigated the transfer of tetracycline (TC) from raw milk to different dairy products. The highest TC content was found in milk from household farmers, while sour milk had TC levels comparable to raw milk. Heat treatment of the milk resulted in a decrease in TC content.
Article
Medicine, Research & Experimental
Diana-Carina Iovanovici, Alina-Gariela Negru, Carmen Delia Nistor Cseppento, Calin Florin Bochis, Bombonica Gabriela Dogaru, Anamaria Jurcau, Babes Elena Emilia, Nicoleta Anamaria Pascalau, Timea Claudia Ghitea, Alexa Florina Bungau, Simona Gabriela Bungau
Summary: The aim of this prospective study was to assess the incidence of physical frailty in patients with HF and the role of physical exercise in improving physical performance. The study found that 20.56% of patients enrolled in the study had mild and moderate frailty, and 2.83% had severe frailty. The prevalence of mild and moderate frailty was significantly higher in the HF group compared to the non-HF group. Exercise-based rehabilitation was found to improve physical performance and increase independence in daily activities and functional performance in HF patients.
