Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice

Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages

(2021) Ji Cao et al.   MOLECULAR IMMUNOLOGY

Reductively modified albumin attenuates DSS-Induced mouse colitis through rebalancing systemic redox state

(2021) Xiawen Yang et al.   Redox Biology

Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and IRS1-AKT-GLUT2 signaling pathways

(2020) Longlong Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR

(2020) Brandyn D. Henriksbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

(2020) Alexandra Vaccaro et al.   CELL

SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis

(2020) Jiyoung Hwang et al.   Redox Biology

The intestinal barrier, an arbitrator turned provocateur in IBD

(2020) Saurabh Mehandru et al.   Nature Reviews Gastroenterology & Hepatology

Pathophysiology of Inflammatory Bowel Diseases

(2020) John T. Chang   NEW ENGLAND JOURNAL OF MEDICINE

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review

(2019) Dong Yeon Jeong et al.   AUTOIMMUNITY REVIEWS

Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice

(2019) Chin-Hee Song et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases

(2019) Yu Tao et al.   FASEB JOURNAL

Effect of dehydroepiandrosterone on the immune response and gut microbiota in dextran sulfate sodium-induced colitis mice

(2019) Ji Cao et al.   MOLECULAR IMMUNOLOGY

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Control and dysregulation of redox signalling in the gastrointestinal tract

(2018) Eric L. Campbell et al.   Nature Reviews Gastroenterology & Hepatology

Inflammatory Bowel Disease and the NLRP3 Inflammasome

(2017) Thirumala-Devi Kanneganti   NEW ENGLAND JOURNAL OF MEDICINE

Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal

(2017) Yan-Cheng Dai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways

(2017) Wei Hu et al.   Scientific Reports

Redox regulation of proteasome function

(2017) Maria Lefaki et al.   Redox Biology

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

(2016) Jonathan Landy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions

(2016) Stephen M. Vindigni et al.   Therapeutic Advances in Gastroenterology

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells

(2015) Yun Teng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dehydroepiandrosterone: A neuroactive steroid

(2015) Luboslav Stárka et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

(2014) Suryasarathi Dasgupta et al.   Cell Host & Microbe

Dehydroepiandrosterone (DHEA): Hypes and Hopes

(2014) Krzysztof Rutkowski et al.   DRUGS

Role of Androgen and Estrogen Receptors for the Action of Dehydroepiandrosterone (DHEA)

(2014) Cecilia Engdahl et al.   ENDOCRINOLOGY

Mechanism of IL-1 -Induced Increase in Intestinal Epithelial Tight Junction Permeability

(2014) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway

(2013) Chong Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of serum dehydroepiandrosterone sulfate and cognition in older adults: Sex steroid, inflammatory, and metabolic mechanisms.

(2013) Kerry L. Hildreth et al.   NEUROPSYCHOLOGY

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

(2011) Kaoru Saijo et al.   CELL

Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells

(2011) Mathieu Da Silva et al.   FREE RADICAL BIOLOGY AND MEDICINE

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

The G-protein-coupled estrogen receptor GPER in health and disease

(2011) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

NF-κB in the regulation of epithelial homeostasis and inflammation

(2010) Andy Wullaert et al.   CELL RESEARCH

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

(2010) Alicja Kasperska-Zajac   INFLAMMATION

Involvement of Interferon-γ in Bowel Disease Pathogenesis by Nitric Oxide Pathway: A Study in Algerian Patients

(2010) Hayet Rafa et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages

(2010) Jennifer A. Rettew et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients

(2010) Na Wang et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dehydroepiandrosterone modulates antioxidant enzymes and Akt signaling in healthy Wistar rat hearts

(2008) Maria H.V.M. Jacob et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY