Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways

(2021) Hany H. Arab et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Role of sodium glucose cotransporter type 2 inhibitors dapagliflozin on diabetic nephropathy in rats; Inflammation, angiogenesis and apoptosis

(2021) Shimaa K. Elkazzaz et al.   LIFE SCIENCES

Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions and relation to morbidity

(2021) Christoffer Juul-Nielsen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

(2020) Shuya Kasai et al.   Biomolecules

Roles of Nrf2 in Protecting the Kidney from Oxidative Damage

(2020) Masahiro Nezu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

(2020) Anne C. Hesp et al.   KIDNEY INTERNATIONAL

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Inflammation and Premature Ageing in Chronic Kidney Disease

(2020) Thomas Ebert et al.   Toxins

Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease

(2020) Christopher D. Wiley   Current Diabetes Reports

Melatonin Suppresses Renal Cortical Fibrosis by Inhibiting Cytoskeleton Reorganization and Mitochondrial Dysfunction through Regulation of miR-4516

(2020) Yeo Min Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction

(2020) Xinxia Luo et al.   LIFE SCIENCES

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury

(2020) Lara Console et al.   Frontiers in Physiology

Nrf2 contributes to the weight gain of mice during space travel

(2020) Takafumi Suzuki et al.   Communications Biology

Protective Role of Nrf2 in Renal Disease

(2020) Melania Guerrero-Hue et al.   Antioxidants

Endothelium structure and function in kidney health and disease

(2019) Noemie Jourde-Chiche et al.   Nature Reviews Nephrology

Angiotensin-converting enzyme inhibitors or angiotensin receptor blocker monotherapy retard deterioration of renal function in Taiwanese chronic kidney disease population

(2019) Cai-Mei Zheng et al.   Scientific Reports

Activated NF-κB/Nrf2 and Wnt/β-catenin pathways are associated with lipid metabolism in CKD patients with microalbuminuria and macroalbuminuria

(2019) Ya-Long Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

(2019) Monika A. Niewczas et al.   NATURE MEDICINE

Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2–related factor 2—lessons from evolution, the animal kingdom and rare progeroid syndromes

(2019) Peter Stenvinkel et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mitochondrial dysfunction in diabetic kidney disease

(2019) Pascal Zhongping Wei et al.   CLINICA CHIMICA ACTA

Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function

(2019) Hajime Nagasu et al.   FASEB JOURNAL

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

(2019) Meng-Chen Lu et al.   Redox Biology

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

Inflammatory Mechanisms as New Biomarkers and Therapeutic Targets for Diabetic Kidney Disease

(2018) Radica Z. Alicic et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

The role of the immune system in kidney disease

(2018) J. Tecklenborg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

Rethinking progression of CKD as a process of punctuated equilibrium

(2018) Richard J. Johnson et al.   Nature Reviews Nephrology

OUP accepted manuscript

(2018)   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Predictive value of spot versus 24-hour measures of proteinuria for death, end-stage kidney disease or chronic kidney disease progression

(2018) Tracey Ying et al.   BMC Nephrology

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis

(2018) Seung-Ki Kwok et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Oxidative stress in chronic kidney disease

(2018) Kristien Daenen et al.   PEDIATRIC NEPHROLOGY

Nrf2 activator for the treatment of kidney diseases

(2018) Kengo Yamawaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondria in innate immune signaling

(2018) Balaji Banoth et al.   Translational Research

The Emerging Role of Pathogenesis of IgA Nephropathy

(2018) Meng-Yu Wu et al.   Journal of Clinical Medicine

Sodium-glucose cotransporter inhibitors and oxidative stress: An update

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolism as a guiding force for immunity

(2018) Jonathan Jung et al.   NATURE CELL BIOLOGY

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB

(2017) Lili Kong et al.   Oxidative Medicine and Cellular Longevity

New insights into the pathogenesis of IgA nephropathy

(2017) See Cheng Yeo et al.   PEDIATRIC NEPHROLOGY

Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling

(2017) Dan Dong et al.   Oncotarget

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

The Players: Cells Involved in Glomerular Disease

(2016) A. R. Kitching et al.   Clinical Journal of the American Society of Nephrology

Inflammation and Progression of CKD: The CRIC Study

(2016) R. L. Amdur et al.   Clinical Journal of the American Society of Nephrology

Renal disease pathophysiology and treatment: contributions from the rat

(2016) Linda J. Mullins et al.   Disease Models & Mechanisms

Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study

(2016) A. Tin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genotypic and phenotypic predictors of inflammation in patients with chronic kidney disease

(2016) Karin Luttropp et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes

(2016) Abraham Said Arellano-Buendía et al.   Oxidative Medicine and Cellular Longevity

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis

(2016) Andreas Kronbichler et al.   Biomed Research International

Update on Inflammation in Chronic Kidney Disease

(2015) Oleh M. Akchurin et al.   BLOOD PURIFICATION

Nrf2 in health and disease: current and future clinical implications

(2015) O. Al-Sawaf et al.   CLINICAL SCIENCE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

NRF2 and NF-κB mRNA expression in chronic kidney disease: a focus on nondialysis patients

(2015) Viviane O. Leal et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

(2015) Li Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory Cytokines in Diabetic Nephropathy

(2015) Javier Donate-Correa et al.   Journal of Diabetes Research

Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment

(2014) Judy Savige   JOURNAL OF PHYSIOLOGY-LONDON

Integrative Biology Identifies Shared Transcriptional Networks in CKD

(2014) S. Martini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease

(2014) Bo-hyun Choi et al.   MOLECULES

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

Chronic kidney disease and premature ageing

(2014) Jeroen P. Kooman et al.   Nature Reviews Nephrology

Targeting inflammation: New therapeutic approaches in chronic kidney disease (CKD)

(2014) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Overview of the cellular and molecular basis of kidney fibrosis

(2014) Allison A. Eddy   Kidney International Supplements

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome

(2013) Shun-Min Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice

(2013) Manchang Liu et al.   KIDNEY INTERNATIONAL

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

Novel insights from genetic and epigenetic studies in understanding the complex uraemic phenotype

(2013) A. Witasp et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

IgA Nephropathy

(2013) Robert J. Wyatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   XENOBIOTICA

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   Redox Biology

Neutralization of Tumor Necrosis Factor-Alpha Reduces Renal Fibrosis and Hypertension in Rats with Renal Failure

(2012) Frédérick J. Therrien et al.   AMERICAN JOURNAL OF NEPHROLOGY

Nrf2–keap1 system versus NF-κB: The good and the evil in chronic kidney disease?

(2012) Liliana Magnago Pedruzzi et al.   BIOCHIMIE

Aldosterone, oxidative stress, and NF-κB activation in hypertension-related cardiovascular and renal diseases

(2012) Nina Queisser et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

(2012) S. Nlandu Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glomerular hyperfiltration: definitions, mechanisms and clinical implications

(2012) Imed Helal et al.   Nature Reviews Nephrology

An update on the pathomechanisms and future therapies of Alport syndrome

(2012) Damien Noone et al.   PEDIATRIC NEPHROLOGY

Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis

(2011) Xiaoni Kong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Intrarenal Angiotensin System Activation, Oxidative Stress, Inflammation, and Impaired Nuclear Factor-Erythroid-2-Related Factor 2 Activity in the Progression of Focal Glomerulosclerosis

(2011) H. J. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Macrophages Promote Cyst Growth in Polycystic Kidney Disease

(2011) A. Karihaloo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study

(2011) Anoop Shankar et al.   KIDNEY INTERNATIONAL

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Glomerular pathology in Alport syndrome: a molecular perspective

(2011) Dominic Cosgrove   PEDIATRIC NEPHROLOGY

Proteinuria: detection and role in native renal disease progression

(2011) Jose Luis Gorriz et al.   Transplantation Reviews

Effects of Specific Genes Activating RAGE on Polycystic Kidney Disease

(2010) Eun Young Park et al.   AMERICAN JOURNAL OF NEPHROLOGY

The Nrf2–Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO)

(2010) Martin E. Rinaldi Tosi et al.   CELL STRESS & CHAPERONES

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

(2010) María T Grande et al.   Journal of Inflammation-London

Mechanistic connection between inflammation and fibrosis

(2010) Soo Bong Lee et al.   KIDNEY INTERNATIONAL

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

(2010) Imari Mimura et al.   Nature Reviews Nephrology

Characterisation of renal immune cell infiltrates in children with nephrotic syndrome

(2010) Kerstin Benz et al.   PEDIATRIC NEPHROLOGY

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Association of Urinary Inflammatory Markers and Renal Decline in Microalbuminuric Type 1 Diabetics

(2008) P. P. Wolkow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of Inflammatory Cytokines in Diabetic Nephropathy

(2008) J. F. Navarro-Gonzalez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overview of factors contributing to the pathophysiology of progressive renal disease

(2008) Detlef O. Schlondorff   KIDNEY INTERNATIONAL

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

(2008) Leon G. Fine et al.   KIDNEY INTERNATIONAL

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE

Effect of aggregated immunoglobulin A1 from immunoglobulin A nephropathy patients on nephrin expression in podocytes

(2008) CHENG WANG et al.   NEPHROLOGY

Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy

(2008) K. N. Lai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION