Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem

Advancement of Sensor Integrated Organ-on-Chip Devices

(2021) Gabriel A. Clarke et al.   SENSORS

Building the Next Generation of Humanized Hemato-Lymphoid System Mice

(2021) Tijana Martinov et al.   Frontiers in Immunology

Organ-on-chip applications in drug discovery: an end user perspective

(2021) Naomi Clapp et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microphysiological systems to study tumor-stroma interactions in brain cancer

(2021) Edward R. Neves et al.   BRAIN RESEARCH BULLETIN

Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine

(2021) Fikadu Ejeta   Drug Design Development and Therapy

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Heart-on-a-chip Model with Integrated Extra- and Intra-cellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia

(2020) Haitao Liu et al.   NANO LETTERS

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

3D Immunocompetent Organ‐on‐a‐Chip Models

(2020) Sushila Maharjan et al.   Small Methods

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

(2020) Junyoung Kim et al.   ACS Nano

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

(2020) James T. Shoemaker et al.   Frontiers in Molecular Biosciences

Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study

(2020) Anne P. Starling et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Renal reabsorption in 3D vascularized proximal tubule models

(2019) Neil Y. C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update on calcium carbonate nanoparticles as cancer drug/gene delivery system

(2019) Solmaz Maleki Dizaj et al.   Expert Opinion on Drug Delivery

Organ-on-a-chip technology: turningt its potential for clinical benefit into reality

(2019) Malcolm Haddrick et al.   DRUG DISCOVERY TODAY

Human-Derived Organ-on-a-Chip for Personalized Drug Development

(2019) Yasamin A. Jodat et al.   CURRENT PHARMACEUTICAL DESIGN

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

(2019) Alison J. Foster et al.   ARCHIVES OF TOXICOLOGY

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Comparison of Immune System Development in Nonclinical Species and Humans: Closing Information Gaps for Immunotoxicity Testing and Human Translatability

(2019) H. Skaggs et al.   REPRODUCTIVE TOXICOLOGY

Brain-on-a-chip: A history of development and future perspective

(2019) Seokyoung Bang et al.   Biomicrofluidics

Airway and alveolar epithelial cells in culture

(2019) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

Deconstructed Microfluidic Bone Marrow On‐A‐Chip to Study Normal and Malignant Hemopoietic Cell–Niche Interactions

(2019) Julio Aleman et al.   Small

A heart-on-a-chip platform for online monitoring of contractile behavior via digital image processing and piezoelectric sensing technique

(2019) Mutsuhito Sakamiya et al.   MEDICAL ENGINEERING & PHYSICS

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

(2018) Amy Cochrane et al.   ADVANCED DRUG DELIVERY REVIEWS

Modifications to the “Classical” Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: A Less Toxic Approach is Feasible and Improves the Neurological Condition. A Mexican Perspective

(2018) Guillermo Jose Ruiz-Argüelles et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

(2018) Mouhita Humayun et al.   LAB ON A CHIP

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system

(2018) Delphine Garnier et al.   Scientific Reports

Engineered 3D vascular and neuronal networks in a microfluidic platform

(2018) Tatsuya Osaki et al.   Scientific Reports

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development

(2018) Samuel Sances et al.   Stem Cell Reports

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

(2018) Yoonhee Jin et al.   Nature Biomedical Engineering

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

(2018) Olga Lage et al.   Marine Drugs

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in hPSC cultures

(2018) Igor I. Slukvin et al.   EXPERIMENTAL HEMATOLOGY

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Roles of fluid shear stress and retinoic acid in the differentiation of primary cultured human podocytes

(2017) Seung Hee Yang et al.   EXPERIMENTAL CELL RESEARCH

Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

(2017) Yu Huang et al.   EXPERIMENTAL CELL RESEARCH

Assembly of Hepatocyte Spheroids Using Magnetic 3D Cell Culture for CYP450 Inhibition/Induction

(2017) Pujan Desai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

(2017) Li Wang et al.   LAB ON A CHIP

Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes

(2017) Hae Ung Lee et al.   PLoS One

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

(2017) Sarah Jäkel et al.   Frontiers in Cellular Neuroscience

Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms

(2017) Armin Geraili et al.   Advanced Healthcare Materials

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

(2017) Shelby M. King et al.   Frontiers in Physiology

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Integration of neurogenesis and angiogenesis models for constructing a neurovascular tissue

(2017) Hiroyuki Uwamori et al.   Scientific Reports

On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

(2016) Chao Ma et al.   ANALYTICAL CHEMISTRY

From Cajal to Connectome and Beyond

(2016) Larry W. Swanson et al.   Annual Review of Neuroscience

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Compartmentalized Platforms for Neuro-Pharmacological Research

(2016) Amol D. Jadhav et al.   Current Neuropharmacology

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Cells and Culture Systems Used to Model the Small Airway Epithelium

(2016) Rudra Bhowmick et al.   LUNG

For whom the cells pull: Hydrogel and micropost devices for measuring traction forces

(2016) Alexandre J.S. Ribeiro et al.   METHODS

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine

(2016) Aziz Eftekhari et al.   TOXICOLOGY MECHANISMS AND METHODS

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine

(2016) Aziz Eftekhari et al.   TOXICOLOGY MECHANISMS AND METHODS

A Microchip for High-Throughput Axon Growth Drug Screening

(2016) Hyun Kim et al.   Micromachines

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Bioengineered kidney tubules efficiently excrete uremic toxins

(2016) J. Jansen et al.   Scientific Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke

(2015) Gila Pirzad Jahromi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

In vitro myelin formation using embryonic stem cells

(2015) B. E. Kerman et al.   DEVELOPMENT

Mechanically Stimulated Contraction of Engineered Cardiac Constructs Using a Microcantilever

(2015) Peter A. Galie et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

(2015) J. Jansen et al.   Scientific Reports

Hepatic organoids for microfluidic drug screening

(2014) Sam H. Au et al.   LAB ON A CHIP

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia

(2014) V. Raghavan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators

(2014) Irina Elcheva et al.   Nature Communications

An Experimental Investigation of Micro Pulsating Heat Pipes

(2014) Kai-Shing Yang et al.   Micromachines

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

(2014) Rafael Franco et al.   Frontiers in Pharmacology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats

(2013) Regis Baudoin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

(2013) Eva-Maria Materne et al.   LAB ON A CHIP

Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity

(2013) Nicola Ferri et al.   PHARMACOLOGY & THERAPEUTICS

Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid

(2013) Young Bok (Abraham) Kang et al.   Biofabrication

Interfacial stress affects rat alveolar type II cell signaling and gene expression

(2012) Nina Hobi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Organotypic liver culture models: Meeting current challenges in toxicity testing

(2012) Edward L. LeCluyse et al.   CRITICAL REVIEWS IN TOXICOLOGY

Molecular mechanisms of cryptococcal meningitis

(2012) Tong-Bao Liu et al.   Virulence

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Interfacial sensing by alveolar type II cells: a new concept in lung physiology?

(2011) Andrea Ravasio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Therapeutic Effects of a Combinatorial Treatment of Simvastatin and Bone Marrow Stromal Cells on Experimental Embolic Stroke

(2011) G. Pirzad Jahromi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging

(2011) Sang Bok Kim et al.   LAB ON A CHIP

Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

(2010) Kyung-Jin Jang et al.   Integrative Biology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Alzheimer's disease drug development and the problem of the blood-brain barrier

(2009) William M. Pardridge   Alzheimers & Dementia

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP