Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

An expert consortium review of the EC-commissioned report “Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010”

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Modeling Life

(2012) Michael L. Shuler   ANNALS OF BIOMEDICAL ENGINEERING

Optimised testing strategies for skin sensitization – The LLNA and beyond

(2012) David Basketter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

FDA's Approach to Regulation of Products of Nanotechnology

(2012) M. A. Hamburg   SCIENCE

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Whole-Organ Tissue Engineering: Decellularization and Recellularization of Three-Dimensional Matrix Scaffolds

(2011) Stephen F. Badylak et al.   Annual Review of Biomedical Engineering

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

New Directions in Toxicity Testing

(2011) Daniel Krewski et al.   Annual Review of Public Health

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity

(2011) Paul M. van Midwoud et al.   BIOTECHNOLOGY AND BIOENGINEERING

A theoretical approach to zonation in a bioartificial liver

(2011) Adam J. Davidson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells

(2011) Dmitry A. Sakharov et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Computational chemistry, systems biology and toxicology. Harnessing the chemistry of life: revolutionizing toxicology. A commentary

(2011) Ian Kimber et al.   JOURNAL OF APPLIED TOXICOLOGY

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

(2011) Robert Meissner et al.   LAB ON A CHIP

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Noninvasive biochemical monitoring of physiological stress by Fourier transform infrared saliva spectroscopy

(2010) Svetlana Khaustova et al.   ANALYST

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Current development of bioreactors for extracorporeal bioartificial liver (Review)

(2010) Yan Wang et al.   Biointerphases

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The controlled presentation of TGF-β1 to hepatocytes in a 3D-microfluidic cell culture system

(2009) Chi Zhang et al.   BIOMATERIALS

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

(2009) Paul M. van Midwoud et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Study of the Crosstalk Between Hepatocytes and Endothelial Cells Using a Novel Multicompartmental Bioreactor: A Comparison Between Connected Cultures and Cocultures

(2009) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

A gel-free 3D microfluidic cell culture system

(2008) Siew-Min Ong et al.   BIOMATERIALS

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies

(2008) Samantha M. Hattersley et al.   LAB ON A CHIP

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

(2008) Bo Ma et al.   LAB ON A CHIP

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Connected Culture of Murine Hepatocytes and Human Umbilical Vein Endothelial Cells in a Multicompartmental Bioreactor

(2008) Federico Vozzi et al.   TISSUE ENGINEERING PART A

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity

(2007) Kjetil Elvevold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Toxicity testing in the 21st century: A vision and a strategy

(2007) Steven Gibb   REPRODUCTIVE TOXICOLOGY

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS