Advancement of Sensor Integrated Organ-on-Chip Devices

Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer

(2020) Jessica Sierra et al.   SENSORS

A Lab-on-a-Chip system with an embedded porous membrane-based impedance biosensor array for nanoparticle risk assessment on placental Bewo trophoblast cells

(2020) Patrick Schuller et al.   SENSORS AND ACTUATORS B-CHEMICAL

An integrated PK‐PD model for cortisol and the 17‐hydroxyprogesterone and androstenedione biomarkers in children with congenital adrenal hyperplasia

(2020) Mahmoud Al‐Kofahi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Real-Time Physiological Sensors Based Liver-on-Chip Device for Monitoring Drug Toxicity

(2020) Hafiz Muhammad Umer Farooqi et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

A Two-Dimensional Affinity Capture and Separation Mini-Platform for the Isolation, Enrichment, and Quantification of Biomarkers and Its Potential Use for Liquid Biopsy

(2020) Norberto A. Guzman et al.   Biomedicines

Human-on-a-Chip Systems: Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System (Adv. Funct. Mater. 8/2019)

(2019) Carlota Oleaga et al.   ADVANCED FUNCTIONAL MATERIALS

Photo-Cross-Linked Poly(ethylene glycol) Diacrylate Hydrogels: Spherical Microparticles to Bow Tie-Shaped Microfibers

(2019) Farrokh Sharifi et al.   ACS Applied Materials & Interfaces

Preclinical PK/PD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer

(2019) Qing-yu Yao et al.   ACTA PHARMACOLOGICA SINICA

Integrating Flexible Electrochemical Sensor into Microfluidic Chip for Simulating and Monitoring Vascular Mechanotransduction

(2019) Zi‐He Jin et al.   Small

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

(2019) Anna Kalmykov et al.   Science Advances

Recent advances in microfluidics for drug screening

(2019) Jiahui Sun et al.   Biomicrofluidics

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment

(2019) Muhammad Asad Ullah Khalid et al.   BIOCHEMICAL ENGINEERING JOURNAL

Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues

(2018) Haijiao Liu et al.   BIOMATERIALS

Bioelectronic organ-based sensor for microfluidic real-time analysis of the demand in insulin

(2018) R. Perrier et al.   BIOSENSORS & BIOELECTRONICS

Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems

(2018) Kristina R. Rivera et al.   BIOSENSORS & BIOELECTRONICS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip system

(2018) A. Moya et al.   LAB ON A CHIP

Every Breath You Take: Non-invasive Real-Time Oxygen Biosensing in Two- and Three-Dimensional Microfluidic Cell Models

(2018) Helene Zirath et al.   Frontiers in Physiology

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models

(2018) Guido Caluori et al.   BIOSENSORS & BIOELECTRONICS

LncRNA MALAT1 protects cardiomyocytes from isoproterenol‐induced apoptosis through sponging miR‐558 to enhance ULK1‐mediated protective autophagy

(2018) Xiaoyan Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

(2018) Vanessa L. Hale et al.   Genome Medicine

Two Forms of Electrical Transmission Between Neurons

(2018) Donald S. Faber et al.   Frontiers in Molecular Neuroscience

Self-contained, low-cost Body-on-a-Chip systems for drug development

(2017) Ying I Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data

(2017) Elisabet I Nielsen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A microfluidic circulatory system integrated with capillary-assisted pressure sensors

(2017) Yangfan Chen et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

(2017) Olivier Y. F. Henry et al.   LAB ON A CHIP

Network Topology in Soft Gels: Hardening and Softening Materials

(2017) Mehdi Bouzid et al.   LANGMUIR

The Diverse Range of Possible Cell Membrane Interactions with Substrates: Drug Delivery, Interfaces and Mobility

(2017) Hyun-Sook Jang   MOLECULES

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using cell deformation and motion to predict forces and collective behavior in morphogenesis

(2017) Matthias Merkel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Duchenne and Becker Muscular Dystrophies: A Review of Animal Models, Clinical End Points, and Biomarker Quantification

(2017) Kristin Wilson et al.   TOXICOLOGIC PATHOLOGY

Microbial metabolites in nutrition, healthcare and agriculture

(2017) Rajendra Singh et al.   3 Biotech

Microbial metabolites in nutrition, healthcare and agriculture

(2017) Rajendra Singh et al.   3 Biotech

Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors

(2017) Kyung Jin Son et al.   Microsystems & Nanoengineering

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Polycaprolactone Microfibrous Scaffolds to Navigate Neural Stem Cells

(2016) Farrokh Sharifi et al.   BIOMACROMOLECULES

Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation

(2016) Angelo S. Mao et al.   BIOMATERIALS

Direct quantification of transendothelial electrical resistance in organs-on-chips

(2016) Marinke W. van der Helm et al.   BIOSENSORS & BIOELECTRONICS

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Substrate stiffness modulates lung cancer cell migration but not epithelial to mesenchymal transition

(2016) V. C. Shukla et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

A decade of progress in tissue engineering

(2016) Ali Khademhosseini et al.   Nature Protocols

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ stress observation in oxide films and how tensile stress influences oxygen ion conduction

(2016) Aline Fluri et al.   Nature Communications

Absorptive supramolecular elastomer wound dressing based on polydimethylsiloxane–(polyethylene glycol)–polydimethylsiloxane copolymer: preparation and characterization

(2016) Wenwen Deng et al.   RSC Advances

Food for thought... on the economics of animal testing

(2016) Annamaria Bottini   ALTEX-Alternatives to Animal Experimentation

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells

(2015) Michelle L. McCully et al.   JOURNAL OF IMMUNOLOGY

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Non-invasive monitoring of oxygen delivery in acutely ill patients: new frontiers

(2015) Azriel Perel   Annals of Intensive Care

Study of Physically Transient Insulating Materials as a Potential Platform for Transient Electronics and Bioelectronics

(2014) Handan Acar et al.   ADVANCED FUNCTIONAL MATERIALS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

On-chip development of hydrogel microfibers from round to square/ribbon shape

(2014) Zhenhua Bai et al.   Journal of Materials Chemistry A

Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness

(2014) M. Moazzem Hossain et al.   FEBS Open Bio

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip

(2013) Ashutosh Agarwal et al.   ADVANCED FUNCTIONAL MATERIALS

Three-Dimensional Paper-Based Microfluidic Device for Assays of Protein and Glucose in Urine

(2013) Deidre Sechi et al.   ANALYTICAL CHEMISTRY

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Toxicity of graphene nanoflakes evaluated by cell-based electrochemical impedance biosensing

(2013) Ok Ja Yoon et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Sculpting Organs: Mechanical Regulation of Tissue Development

(2012) Celeste M. Nelson et al.   Annual Review of Biomedical Engineering

Epidermal Differential Impedance Sensor for Conformal Skin Hydration Monitoring

(2012) Xian Huang et al.   Biointerphases

Nanoparticles: a review of particle toxicology following inhalation exposure

(2012) Shahnaz Bakand et al.   INHALATION TOXICOLOGY

Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane

(2012) Raymond H. W. Lam et al.   Integrative Biology

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations

(2012) Judith A. Finegold et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Optofluidic characterization of marine algae using a microflow cytometer

(2011) Nastaran Hashemi et al.   Biomicrofluidics

Microflow Cytometer for optical analysis of phytoplankton

(2011) Nastaran Hashemi et al.   BIOSENSORS & BIOELECTRONICS

Dynamic Monitoring of Metal Oxide Nanoparticle Toxicity by Label Free Impedance Sensing

(2011) Joanna M. Seiffert et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integrated ionic liquid-based electrofluidic circuits for pressure sensing within polydimethylsiloxane microfluidic systems

(2011) Chueh-Yu Wu et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Ethical and Scientific Considerations Regarding Animal Testing and Research

(2011) Hope R. Ferdowsian et al.   PLoS One

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Epicardium-derived cells enhance proliferation, cellular maturation and alignment of cardiomyocytes

(2010) Alida Weeke-Klimp et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dynamic reversibility of hydrodynamic focusing for recycling sheath fluid

(2010) Nastaran Hashemi et al.   LAB ON A CHIP

On-chip epithelial barrier function assays using electrical impedance spectroscopy

(2010) Tao Sun et al.   LAB ON A CHIP

Cyclic Stretch, Reactive Oxygen Species, and Vascular Remodeling

(2009) Konstantin G. Birukov   ANTIOXIDANTS & REDOX SIGNALING

Improved cell sensitivity and longevity in a rapid impedance-based toxicity sensor

(2009) Theresa M. Curtis et al.   JOURNAL OF APPLIED TOXICOLOGY

Bioimaging Probes for Reactive Oxygen Species and Reactive Nitrogen Species

(2009) Tetsuo Nagano   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Working in partnership to advance the 3Rs in toxicity testing

(2009) Anthony M. Holmes et al.   TOXICOLOGY

Tissue-to-cellular level deformation coupling in cell micro-integrated elastomeric scaffolds

(2008) John A. Stella et al.   BIOMATERIALS

Heart rate variability and pain: Associations of two interrelated homeostatic processes

(2007) Bradley M. Appelhans et al.   BIOLOGICAL PSYCHOLOGY

Elastic Membrane Heterogeneity of Living Cells Revealed by Stiff Nanoscale Membrane Domains

(2007) Charles Roduit et al.   BIOPHYSICAL JOURNAL