Organotypic liver culture models: Meeting current challenges in toxicity testing

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche

(2011) Oswaldo A. Lozoya et al.   BIOMATERIALS

Microfluidic cell culture chip with multiplexed medium delivery and efficient cell/scaffold loading mechanisms for high-throughput perfusion 3-dimensional cell culture-based assays

(2011) Song-Bin Huang et al.   BIOMEDICAL MICRODEVICES

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

Human hepatic stem cell and maturational liver lineage biology

(2011) Rachael Turner et al.   HEPATOLOGY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

(2011) Buzz Baum et al.   JOURNAL OF CELL BIOLOGY

A living system on a chip

(2011) Monya Baker   NATURE

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

(2011) Carien M. Niessen et al.   PHYSIOLOGICAL REVIEWS

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

(2011) Imran Shah et al.   PLoS One

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat

(2011) Kyoungju Choi et al.   TOXICOLOGY IN VITRO

Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity

(2010) Guanhua Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response

(2010) Stephan J. A. C. Peters et al.   CELL AND TISSUE RESEARCH

E-Cadherin Protects Primary Hepatocyte Spheroids from Cell Death by a Caspase-Independent Mechanism

(2010) Jennifer L. Luebke-Wheeler et al.   CELL TRANSPLANTATION

Design and Application of Microfluidic Systems for In Vitro Pharmacokinetic Evaluation of Drug Candidates

(2010) T. Maguire et al.   CURRENT DRUG METABOLISM

In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs

(2010) M.J. Gomez-Lechon et al.   CURRENT PHARMACEUTICAL DESIGN

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

(2010) Qin Meng   Expert Opinion on Drug Metabolism & Toxicology

Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates

(2010) Yunfang Wang et al.   HEPATOLOGY

Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds

(2010) Yunfang Wang et al.   HEPATOLOGY

Hypoxia and reoxygenation of primary human hepatocytes induce proteome changes of glucose metabolism, oxidative protection and peroxisomal function

(2010) Strey   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations

(2010) Victoria C. Cogger et al.   JOURNAL OF STRUCTURAL BIOLOGY

Virtual Tissues in Toxicology

(2010) Imran Shah et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Molecular Biology of Liver Ischemia/Reperfusion Injury: Established Mechanisms and Recent Advancements

(2010) John R. Klune et al.   SURGICAL CLINICS OF NORTH AMERICA

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

(2010) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Predicting Drug–Drug Interactions: An FDA Perspective

(2009) Lei Zhang et al.   AAPS Journal

Human IL-8 Regulates Smooth Muscle Cell VCAM-1 Expression in Response to Endothelial Cells Exposed to Atheroprone Flow

(2009) Nicole E. Hastings et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins

(2009) Michel R. Popoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Engineering liver tissue spheroids with inverted colloidal crystal scaffolds

(2009) Jungwoo Lee et al.   BIOMATERIALS

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies

(2009) Gregor Tuschl et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

(2009) ET Morgan   CLINICAL PHARMACOLOGY & THERAPEUTICS

High Throughput Optimization of Stem Cell Microenvironments

(2009) Fan Yang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

New insights into liver stem cells

(2009) E. Gaudio et al.   DIGESTIVE AND LIVER DISEASE

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Cholangiocyte proliferation and liver fibrosis

(2009) Shannon S. Glaser et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation

(2009) Kwan-Hoon Moon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Alkoxyresorufin O-dealkylase assay using a rat hepatocyte spheroid microarray

(2009) Yusuke Sakai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Cell polarity triggered by cell-cell adhesion via E-cadherin

(2009) R. A. Desai et al.   JOURNAL OF CELL SCIENCE

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair

(2009) Brigitte Vollmar et al.   PHYSIOLOGICAL REVIEWS

Liver architecture, cell function, and disease

(2009) Hiromi Ishibashi et al.   Seminars in Immunopathology

Phytol-induced Hepatotoxicity in Mice

(2009) John T. Mackie et al.   TOXICOLOGIC PATHOLOGY

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

(2009) Ylva Edling et al.   TOXICOLOGY IN VITRO

ECVAM’s ongoing activities in the area of acute oral toxicity

(2009) Agnieszka Kinsner-Ovaskainen et al.   TOXICOLOGY IN VITRO

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

(2009) Miia Turpeinen et al.   TOXICOLOGY IN VITRO

Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture

(2009) Angelika Langsch et al.   TOXICOLOGY LETTERS

Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway

(2008) Heather Francis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

(2008) W. Lilienblum et al.   ARCHIVES OF TOXICOLOGY

Transcription factors: their potential as targets for an individualized therapeutic approach to cancer

(2008) C Mees et al.   CANCER GENE THERAPY

Wnt/ -Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells

(2008) W. Yang et al.   CANCER RESEARCH

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction

(2008) N. Hariparsad et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Evolving concepts in liver tissue modeling and implications forin vitrotoxicology

(2008) André Guillouzo et al.   Expert Opinion on Drug Metabolism & Toxicology

An update on metabolism studies using human hepatocytes in primary culture

(2008) María José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

(2008) Hesham Basma et al.   GASTROENTEROLOGY

Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

(2008) Giovanna Mazzoleni et al.   Genes and Nutrition

Differentiation of mouse and human embryonic stem cells into hepatic lineages

(2008) Nobuaki Shiraki et al.   GENES TO CELLS

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

(2008) Colleen M. Brophy et al.   HEPATOLOGY

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

The stem cell niche of human livers: Symmetry between development and regeneration

(2008) Lili Zhang et al.   HEPATOLOGY

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

(2008) Kinji Asahina et al.   HEPATOLOGY

Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly

(2008) MR Alison et al.   JOURNAL OF PATHOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

(2008) Sadhana Agarwal et al.   STEM CELLS

Nuclear Magnetic Resonance Metabolomic Footprinting of Human Hepatic Stem Cells and Hepatoblasts Cultured in Hyaluronan-Matrix Hydrogels

(2008) William S. Turner et al.   STEM CELLS

In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art

(2008) Sarah Snykers et al.   STEM CELLS

Gradients in the Liver's Extracellular Matrix Chemistry from Periportal to Pericentral Zones: Influence on Human Hepatic Progenitors

(2008) Randall McClelland et al.   TISSUE ENGINEERING PART A

Quantitative Interpretation of Human Biomonitoring Data

(2008) Harvey J. Clewell et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell shape, cell–cell contact, cell–extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes

(2007) Hiroaki Oda et al.   BIOCHEMICAL PHARMACOLOGY

Understanding mechanisms of toxicity: Insights from drug discovery research

(2007) Keith A. Houck et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY