3D Immunocompetent Organ‐on‐a‐Chip Models

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

(2019) Rustelle Janse van Vuuren et al.   Cancer Cell International

Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model

(2019) Yuta Ando et al.   Advanced Healthcare Materials

A Foreign Body Response-on-a-Chip Platform

(2019) Fatemeh Sharifi et al.   Advanced Healthcare Materials

Human organotypic lymphatic vessel model elucidates microenvironment-dependent signaling and barrier function

(2019) Max M. Gong et al.   BIOMATERIALS

Advances in cancer immunotherapy 2019 – latest trends

(2019) Stephan Kruger et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Integrated cancer tissue engineering models for precision medicine

(2019) Michael E. Bregenzer et al.   PLoS One

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

(2019) Marine Leclerc et al.   Nature Communications

High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform)

(2019) Dohyun Park et al.   Frontiers in Immunology

The Roles of Liver-Resident Lymphocytes in Liver Diseases

(2019) Yanan Wang et al.   Frontiers in Immunology

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

(2018) Lucille C. Rankin et al.   CELL

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

(2018) N. Moore et al.   LAB ON A CHIP

Real-time observation of leukocyte–endothelium interactions in tissue-engineered blood vessel

(2018) Z. Chen et al.   LAB ON A CHIP

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

(2018) Gopu Sriram et al.   Materials Today

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune cells in the adipose tissue

(2018) Kyoung-Jin Chung et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

(2018) Sharon Wei Ling Lee et al.   Frontiers in Immunology

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Towards the development of human immune-system-on-a-chip platforms

(2018) Alessandro Polini et al.   DRUG DISCOVERY TODAY

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer immunotherapy: challenges and clinical applications

(2018) An-Liang Xia et al.   JOURNAL OF MEDICAL GENETICS

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again

(2018) Samantha L. Bucktrout et al.   Genome Medicine

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

(2018) Jose M. Ayuso et al.   OncoImmunology

In Vitro Immune Organs-on-Chip for Drug Development: A Review

(2018) Aya Shanti et al.   Pharmaceutics

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Tissue-Resident Lymphocytes in the Kidney

(2017) Jan-Eric Turner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

(2017) Robert G. Mannino et al.   LAB ON A CHIP

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad

(2017) Bani Ahluwalia et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

(2017) Stefania Parlato et al.   Scientific Reports

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

The Lymphatic System in Disease Processes and Cancer Progression

(2016) Timothy P. Padera et al.   Annual Review of Biomedical Engineering

Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis

(2016) Soichiro Sasaki et al.   CANCER LETTERS

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

(2016) Bumsoo Han et al.   CANCER LETTERS

Hallmarks of Tissue-Resident Lymphocytes

(2016) Xiying Fan et al.   CELL

Peyer's patches: organizing B-cell responses at the intestinal frontier

(2016) Andrea Reboldi et al.   IMMUNOLOGICAL REVIEWS

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases

(2016) Mei Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

The concept of immune surveillance against tumors: The first theories

(2016) Domenico Ribatti   Oncotarget

T Cell Trafficking through Lymphatic Vessels

(2016) Morgan C. Hunter et al.   Frontiers in Immunology

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Immunology and human reproduction

(2015) Diana Alecsandru et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

(2015) Jin-Young Kim et al.   JOURNAL OF BIOTECHNOLOGY

Infection and immunity on a chip: a compartmentalised microfluidic platform to monitor immune cell behaviour in real time

(2015) N. Gopalakrishnan et al.   LAB ON A CHIP

The best of both worlds — managing the cancer, saving the bone

(2015) Issam Makhoul et al.   Nature Reviews Endocrinology

Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

(2015) Miwa Sato et al.   PLoS One

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

A capillary-endothelium-mimetic microfluidic chip for the study of immune responses

(2015) Wen-Hao Wu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing

(2015) Burak Dura et al.   Nature Communications

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

(2015) Jing Bai et al.   Oncotarget

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity

(2015) Christopher V. Carman et al.   Frontiers in Immunology

Intestinal microbial communities associated with acute enteric infections and disease recovery

(2015) Pallavi Singh et al.   Microbiome

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions

(2014) Giuseppina Lamberti et al.   ANALYTICAL CHEMISTRY

Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue

(2014) Hai Qi et al.   Annual Review of Cell and Developmental Biology

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Interleukin-2-stimulated natural killer cells are less susceptible to mycophenolate mofetil than non-activated NK cells: possible consequences for immunotherapy

(2014) Claudia Brehm et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

(2014) Christopher Heylman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

A functional microengineered model of the human splenon-on-a-chip

(2014) L. G. Rigat-Brugarolas et al.   LAB ON A CHIP

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

An extracorporeal blood-cleansing device for sepsis therapy

(2014) Joo H Kang et al.   NATURE MEDICINE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking the lymphatic route: dendritic cell migration to draining lymph nodes

(2014) Alvaro Teijeira et al.   Seminars in Immunopathology

Rubbing salt into wounded endothelium: Sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress

(2014) Johannes Wild et al.   THROMBOSIS AND HAEMOSTASIS

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

(2014) Casey M. Theriot et al.   Nature Communications

The Human Microbiome: From Symbiosis to Pathogenesis

(2013) Emiley A. Eloe-Fadrosh et al.   Annual Review of Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

The Spleen in Local and Systemic Regulation of Immunity

(2013) Vincenzo Bronte et al.   IMMUNITY

The microbiome and regulation of mucosal immunity

(2013) Andrew J. McDermott et al.   IMMUNOLOGY

Lymphatic Function and Immune Regulation in Health and Disease

(2013) Shan Liao et al.   Lymphatic Research and Biology

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

A Three-Dimensional Engineered Artery Model for In Vitro Atherosclerosis Research

(2013) Jérôme Robert et al.   PLoS One

Patient-Specific 3D Microfluidic Tissue Model for Multiple Myeloma

(2013) Wenting Zhang et al.   TISSUE ENGINEERING PART C-METHODS

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Cultivating Our "Frienemies": Viewing Immunity as Microbiome Management

(2013) E. T. Harvill   mBio

Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells

(2013) Bhaskar Mitra et al.   RSC Advances

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

(2013) I. Choi et al.   Cold Spring Harbor Perspectives in Medicine

Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion

(2012) Sung Kyu Kim et al.   ANALYST

Lymph node dissection - understanding the immunological function of lymph nodes

(2012) M. Buettner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

(2012) Clifford J. Rosen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The Gut Barrier

(2012) Franco Scaldaferri et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

(2012) C. N. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone marrow and the control of immunity

(2011) Ende Zhao et al.   Cellular & Molecular Immunology

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

(2011) U. Haessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

(2010) Leonie Rouleau et al.   ANNALS OF BIOMEDICAL ENGINEERING

Stressor Exposure Disrupts Commensal Microbial Populations in the Intestines and Leads to Increased Colonization by Citrobacter rodentium

(2010) M. T. Bailey et al.   INFECTION AND IMMUNITY

Immunological substance testing on human lymphatic micro-organoids in vitro

(2010) Christoph Giese et al.   JOURNAL OF BIOTECHNOLOGY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Lymphedema: A Comprehensive Review

(2009) Avi Shimony et al.   ANNALS OF PLASTIC SURGERY

Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-α and monocytic cell recruitment in a simplified model of arterial bifurcations

(2009) Iwona Cicha et al.   ATHEROSCLEROSIS

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis

(2009) Wen-ting Xu et al.   CANCER LETTERS

The Roles of Antimicrobial Peptides in Innate Host Defense

(2009) Gill Diamond et al.   CURRENT PHARMACEUTICAL DESIGN

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

Antimicrobial peptides and the skin immune defense system

(2008) Jürgen Schauber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Lymphatic drainage function and its immunological implications: From dendritic cell homing to vaccine design

(2008) Melody A. Swartz et al.   SEMINARS IN IMMUNOLOGY

Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity

(2007) Darrell J. Irvine et al.   SEMINARS IN IMMUNOLOGY