The blood-brain barrier in health and disease

Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

(2012) Yasunobu Arima et al.   CELL

Potential Approaches for Drug Delivery to the Brain: Past, Present, and Future

(2012) Vandana Soni et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

The blood-spinal cord barrier: Morphology and Clinical Implications

(2011) Viktor Bartanusz et al.   ANNALS OF NEUROLOGY

Role of ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions

(2011) Igal Ifergan et al.   ANNALS OF NEUROLOGY

The role of neuroinflammation on the pathogenesis of Parkinson's disease

(2011) Young-Cheul Chung et al.   BMB Reports

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking

(2011) Kerstin Göbel et al.   JOURNAL OF AUTOIMMUNITY

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

LSR defines cell corners for tricellular tight junction formation in epithelial cells

(2011) S. Masuda et al.   JOURNAL OF CELL SCIENCE

Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3

(2011) Nadine Ruderisch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

(2011) Brinda Desai Bradaric et al.   JOURNAL OF NEURAL TRANSMISSION

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury

(2011) Yong Gu et al.   JOURNAL OF NEUROCHEMISTRY

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Role of Astrocytes in Neurovascular Coupling

(2011) Gabor C. Petzold et al.   NEURON

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier

(2011) M. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy

(2010) Mathilde Roger et al.   BIOMATERIALS

Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke

(2010) Albert Y Jin et al.   BMC NEUROSCIENCE

Claudins: unlocking the code to tight junction function during embryogenesis and in disease

(2010) IR Gupta et al.   CLINICAL GENETICS

Transporters in the Brain Endothelial Barrier

(2010) M. Ueno et al.   CURRENT MEDICINAL CHEMISTRY

VE-cadherin: at the front, center, and sides of endothelial cell organization and function

(2010) Elizabeth S Harris et al.   CURRENT OPINION IN CELL BIOLOGY

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular Endothelial Growth Factor Increases Permeability of the Blood–Tumor Barrier via Caveolae-Mediated Transcellular Pathway

(2010) Li-ni Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Bradykinin increases the permeability of the blood-tumor barrier by the caveolae-mediated transcellular pathway

(2010) Li-bo Liu et al.   JOURNAL OF NEURO-ONCOLOGY

The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease

(2010) Brian Jeynes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inflammatory Pain Signals an Increase in Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier

(2010) P. T. Ronaldson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

(2010) Rong Jin et al.   NEUROBIOLOGY OF DISEASE

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus

(2010) Fredrik Lauritzen et al.   NEUROBIOLOGY OF DISEASE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis

(2010) Hu Yang   PHARMACEUTICAL RESEARCH

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Current Approaches for Drug Delivery to Central Nervous System

(2010) Sharif Hossain et al.   Current Drug Delivery

Choroid plexus: biology and pathology

(2009) Hartwig Wolburg et al.   ACTA NEUROPATHOLOGICA

Pathology and new players in the pathogenesis of brain edema

(2009) Sukriti Nag et al.   ACTA NEUROPATHOLOGICA

Loss of astrocyte polarity marks blood–brain barrier impairment during experimental autoimmune encephalomyelitis

(2009) Karen Wolburg-Buchholz et al.   ACTA NEUROPATHOLOGICA

Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin

(2009) Tina I. Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The prototype endothelial marker PAL-E is a leukocyte trafficking molecule

(2009) J. Keuschnigg et al.   BLOOD

Impaired blood–brain and blood–spinal cord barriers in mutant SOD1-linked ALS rat

(2009) Charles Nicaise et al.   BRAIN RESEARCH

The contribution of astrocyte signalling to neurovascular coupling

(2009) Giorgio Carmignoto et al.   BRAIN RESEARCH REVIEWS

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Interleukin-25 Expressed by Brain Capillary Endothelial Cells Maintains Blood-Brain Barrier Function in a Protein Kinase Cϵ-dependent Manner

(2009) Yoshifumi Sonobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Culture-Induced Changes in Blood—Brain Barrier Transcriptome: Implications for Amino-Acid Transporters in vivo

(2009) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nutrient transport systems in brain: 40 years of progress

(2009) Reynold Spector   JOURNAL OF NEUROCHEMISTRY

Identification and expression profiling of blood–brain barrier membrane proteins

(2009) Nitin Agarwal et al.   JOURNAL OF NEUROCHEMISTRY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive multiple sclerosis

(2009) Monika Bradl et al.   Seminars in Immunopathology

Role of Interleukin-1β in Early Brain Injury After Subarachnoid Hemorrhage in Mice

(2009) Takumi Sozen et al.   STROKE

Molecular Basis of the Core Structure of Tight Junctions

(2009) M. Furuse   Cold Spring Harbor Perspectives in Biology

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Decreased junctional adhesion molecule-A expression during blood–brain barrier breakdown

(2008) Dennis Yeung et al.   ACTA NEUROPATHOLOGICA

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models

(2008) Eveline H Shue et al.   BMC NEUROSCIENCE

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Epithelial Membrane Protein 1 is a Novel Tight Junction Protein of the Blood—Brain Barrier

(2008) Thorsten Bangsow et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice

(2008) B. W. McColl et al.   JOURNAL OF NEUROSCIENCE

Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines

(2008) Britta Engelhardt   JOURNAL OF THE NEUROLOGICAL SCIENCES

P-Glycoprotein--a Clinical Target in Drug-Refractory Epilepsy?

(2008) R. W. Robey et al.   MOLECULAR PHARMACOLOGY

Interferon-β stabilizes barrier characteristics of the blood–brain barrier in four different species in vitro

(2008) J Kraus et al.   Multiple Sclerosis Journal

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

(2008) L.M. Roberts et al.   NEUROSCIENCE

Blood–brain barrier P-glycoprotein function is not impaired in early Parkinson's disease

(2008) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Barriers in the brain: a renaissance?

(2008) Norman R. Saunders et al.   TRENDS IN NEUROSCIENCES

Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): Compound heterozygous mutation in the claudin 16 (CLDN16) gene

(2008) Geeta Hampson et al.   BMC Nephrology

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

(2007) Yann Wallez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Formation of tight junction: determinants of homophilic interaction between classic claudins

(2007) Jörg Piontek et al.   FASEB JOURNAL