Organ-on-chip applications in drug discovery: an end user perspective

Mechanism and reversal of drug-induced nephrotoxicity on a chip

(2021) Aaron Cohen et al.   Science Translational Medicine

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

(2020) Olivier J. Wouters et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

(2020) Magdalena Kasendra et al.   eLife

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Polylactic is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications

(2020) Alfredo E. Ongaro et al.   ANALYTICAL CHEMISTRY

Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery

(2020) Jason E. Ekert et al.   SLAS Discovery

Hydrogels: The Next Generation Body Materials for Microfluidic Chips?

(2020) Jing Nie et al.   Small

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

(2019) Volker M. Lauschke et al.   Biotechnology Journal

Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates

(2019) Icilio Cavero et al.   Expert Opinion On Drug Safety

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

(2019) Claudia Beaurivage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Are Lifestyle Therapies Effective for NAFLD Treatment?

(2019) Nermeen N. El-Agroudy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro

(2018) Soheila Zeinali et al.   ANGIOGENESIS

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

(2018) N. Moore et al.   LAB ON A CHIP

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

(2018) A. M. Ortega-Prieto et al.   Nature Communications

Strategies for Improving the Maturity of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2018) Chengyi Tu et al.   CIRCULATION RESEARCH

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Medium throughput breathing human primary cell alveolus-on-chip model

(2018) Janick D. Stucki et al.   Scientific Reports

Uncured PDMS inhibits myosin in vitro motility in a microfluidic flow cell

(2018) Yihua Wang et al.   ANALYTICAL BIOCHEMISTRY

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Towards the development of human immune-system-on-a-chip platforms

(2018) Alessandro Polini et al.   DRUG DISCOVERY TODAY

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

(2018) Marie Nguyen et al.   Cell Reports

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

(2018) Jose M. Ayuso et al.   OncoImmunology

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

(2016) Nienke R. Wevers et al.   Scientific Reports

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Simple surface engineering of polydimethylsiloxane with polydopamine for stabilized mesenchymal stem cell adhesion and multipotency

(2015) Yon Jin Chuah et al.   Scientific Reports

Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics

(2015) Cornelia Blume et al.   PLoS One

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

(2015) Peter Loskill et al.   PLoS One

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

(2014) Christopher Heylman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan

(2013) Chihiro Tamaki et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system

(2013) Edward J Kelly et al.   Stem Cell Research & Therapy

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Induced pluripotent stem cells: the new patient?

(2012) Milena Bellin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure

(2010) Frank Sonntag et al.   JOURNAL OF BIOTECHNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS