A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing

(2020) Farah Tasnim et al.   Scientific Reports

Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer

(2019) Yuanping Xiong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices

(2019) Avner Ehrlich et al.   Annual Review of Biomedical Engineering

A new paradigm for lung-conservative total liquid ventilation

(2019) Matthias Kohlhauer et al.   EBioMedicine

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development

(2019) Danilo A Tagle   CURRENT OPINION IN PHARMACOLOGY

Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

(2019) Deng et al.   Micromachines

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac

(2019) Aprajita S. Yadav et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma

(2019) Liwei Lang et al.   Journal of Hematology & Oncology

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

(2018) Alexander J. Kvist et al.   BIOCHEMICAL PHARMACOLOGY

1st UK Interdisciplinary Breast Cancer Symposium—15th–16th January 2018

(2018)   BREAST CANCER RESEARCH AND TREATMENT

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

(2018) Martien van Wenum et al.   Journal of Cell Communication and Signaling

In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

(2018) Kun Zhang et al.   Cell Stem Cell

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research

(2017) Trenton L. Place et al.   FREE RADICAL BIOLOGY AND MEDICINE

A case for the therapeutic use of perfluorocarbon in pulmonary atelectasis

(2016) Shreya Bali et al.   THORAX

EmergingIn VitroLiver Technologies for Drug Metabolism and Inter-Organ Interactions

(2016) Shyam Sundhar Bale et al.   TISSUE ENGINEERING PART B-REVIEWS

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

(2016) Benjamin Berger et al.   Frontiers in Pharmacology

Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: General concepts and assay procedures

(2016) Albert Li   ALTEX-Alternatives to Animal Experimentation

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Long-term culture and expansion of primary human hepatocytes

(2015) Gahl Levy et al.   NATURE BIOTECHNOLOGY

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling

(2015) Philippe Briolotti et al.   TOXICOLOGICAL SCIENCES

Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism

(2014) Takako Ohkura et al.   Drug Metabolism and Pharmacokinetics

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix

(2013) Lorenna D. Buck et al.   BIOTECHNOLOGY AND BIOENGINEERING

Use of perfluorocarbons to enhance the performance of perfused three-dimensional hepatic cultures

(2013) Gengbei Shi et al.   BIOTECHNOLOGY PROGRESS

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

(2012) Sephra N. Rampersad   SENSORS

Perfluorodecalin lavage of a longstanding lung atelectasis in a child with spinal muscle atrophy

(2011) Thore Henrichsen et al.   PEDIATRIC PULMONOLOGY

Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics

(2009) Bruce D. Spiess   JOURNAL OF APPLIED PHYSIOLOGY

Imaging glucose metabolism in perfluorocarbon-perfused hepatocyte bioreactors using positron emission tomography

(2009) Martin Nieuwoudt et al.   JOURNAL OF ARTIFICIAL ORGANS

Culturing thick brain slices: An interstitial 3D microperfusion system for enhanced viability

(2009) Komal Rambani et al.   JOURNAL OF NEUROSCIENCE METHODS

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Oxygenation of Bioartificial Liver Using Perfluorocarbon Emulsion Perftoran on Metabolism of Human Hepatoma C3A Cells

(2008) Andrzej Kinasiewicz et al.   ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY

Enhanced Oxygen Availability Improves Liver-specific Functions of the AMC Bioartificial Liver

(2007) Paul P.C. Poyck et al.   ARTIFICIAL ORGANS