Current Screening Methodologies in Drug Discovery for Selected Human Diseases

Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401

(2018) Wei Fang et al.   JOURNAL OF NATURAL PRODUCTS

Marine natural products

(2018) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Abbreviated atovaquone-proguanil prophylaxis regimens in travellers after leaving malaria-endemic areas: A systematic review

(2018) Jelmer Savelkoel et al.   Travel Medicine and Infectious Disease

Anti-quorum Sensing Activities of Selected Coral Symbiotic Bacterial Extracts From the South China Sea

(2018) Zhi-Ping Ma et al.   Frontiers in Cellular and Infection Microbiology

Antioxidant and antibiofilm activities of secondary metabolites from Ziziphus jujuba leaves used for infusion preparation

(2017) Silvia Damiano et al.   FOOD CHEMISTRY

Chitosan nanoparticles enhances the anti-quorum sensing activity of kaempferol

(2017) Sedef Ilk et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Suppressive drug combinations and their potential to combat antibiotic resistance

(2017) Nina Singh et al.   JOURNAL OF ANTIBIOTICS

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

(2017) Godwin Unekwuojo Ebiloma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

(2017) Matthew W McCarthy et al.   JOURNAL OF INFECTIOUS DISEASES

Beyond Amyloid - Widening the View on Alzheimer's Disease

(2017) Christian Behl et al.   JOURNAL OF NEUROCHEMISTRY

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

(2017) Alka Choudhary et al.   Marine Drugs

Marine natural products

(2017) John W. Blunt et al.   NATURAL PRODUCT REPORTS

A diversity oriented synthesis of natural product inspired molecular libraries

(2017) Jyoti Chauhan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting the Bacterial Orisome in the Search for New Antibiotics

(2017) Julia E. Grimwade et al.   Frontiers in Microbiology

Use of the Soft-agar Overlay Technique to Screen for Bacterially Produced Inhibitory Compounds

(2017) Kevin L. Hockett et al.   Jove-Journal of Visualized Experiments

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

(2017) Leah S. Torrie et al.   ACS Infectious Diseases

The race for antimicrobials in the multidrug resistance era

(2017) Carlos Molina-Santiago et al.   Microbial Biotechnology

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

(2016) Emilie Durieu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial/Antibiofilm Activity and Cytotoxic Studies of β-Thujaplicin Derivatives

(2016) Theano Fotopoulou et al.   ARCHIV DER PHARMAZIE

Identification of inhibitors for vascular endothelial growth factor receptor by using dynamic combinatorial chemistry

(2016) Zhao Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antimicrobial and anti-Quorum Sensing activities of selected medicinal plants of Ethiopia: Implication for development of potent antimicrobial agents

(2016) Ketema Bacha et al.   BMC MICROBIOLOGY

Cancer drug discovery: recent innovative approaches to tumor modeling

(2016) Carrie J. Lovitt et al.   Expert Opinion on Drug Discovery

In vitro activity of plant extracts against biofilm-producing food-related bacteria

(2016) Antonia Nostro et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Research Techniques Made Simple: Techniques to Assess Cell Proliferation

(2016) George A. Romar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Anti-quorum sensing activity of flavonoid-rich fraction from Centella asiatica L. against Pseudomonas aeruginosa PAO1

(2016) H.S. Vasavi et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer’s Disease

(2016) Sheng-nan Wang et al.   NEUROCHEMICAL RESEARCH

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

(2016) Wesley C. Van Voorhis et al.   PLoS Pathogens

Microbial enzymes: industrial progress in 21st century

(2016) Rajendra Singh et al.   3 Biotech

Microbial enzymes: industrial progress in 21st century

(2016) Rajendra Singh et al.   3 Biotech

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

(2016) Guiomar Pérez-Moreno et al.   PLoS One

Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans

(2016) Wen-Ru Li et al.   Scientific Reports

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

(2015) Nataša Anastasov et al.   BMC CANCER

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets

(2015) Milon Mondal et al.   CHEMICAL SOCIETY REVIEWS

Anticancer agent-based marine natural products and related compounds

(2015) Jian-Wei Chen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

(2015) Yiwen Hu et al.   Marine Drugs

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Challenges of Precision Oncology Drug Development and Implementation

(2015) Simon J. Hollingsworth et al.   Public Health Genomics

Overcoming neglect of kinetoplastid diseases

(2015) G. Bilbe   SCIENCE

Anti-Biofilm Activities from Marine Cold Adapted Bacteria Against Staphylococci and Pseudomonas aeruginosa

(2015) Rosanna Papa et al.   Frontiers in Microbiology

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

(2015) Shengyong Ng et al.   Stem Cell Reports

Novel Reporter for Identification of Interference with Acyl Homoserine Lactone and Autoinducer-2 Quorum Sensing

(2014) Nancy Weiland-Bräuer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Design and synthesis of marine natural product-based 1H-indole-2,3-dione scaffold as a new antifouling/antibacterial agent against fouling bacteria

(2014) Mahesh S. Majik et al.   BIOORGANIC CHEMISTRY

GWAS and drug targets

(2014) Chen Cao et al.   BMC GENOMICS

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

(2014) Laura Friggeri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Betaine suppressed Aβ generation by altering amyloid precursor protein processing

(2014) Xiu-Ping Liu et al.   NEUROLOGICAL SCIENCES

Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery

(2014) Y. Z. Xie et al.   NEUROLOGICAL SCIENCES

Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation

(2014) Stacey J Coleman   WORLD JOURNAL OF GASTROENTEROLOGY

Clinical Status of Anti-Cancer Agents Derived from Marine Sources

(2013) Ram Singh et al.   Anti-Cancer Agents in Medicinal Chemistry

Natural product based leads to fight against leishmaniasis

(2013) Nisha Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy

(2013) Francesco Pampaloni et al.   CELL AND TISSUE RESEARCH

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

(2013) Sandra March et al.   Cell Host & Microbe

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Emerging frontiers in detection and control of bacterial biofilms

(2013) Seth Yang-En Tan et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genome editing of human pluripotent stem cells to generate human cellular disease models

(2013) K. Musunuru   Disease Models & Mechanisms

Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP + )-induced cell death via the mitochondrial apoptotic pathway

(2013) Aifeng Zhai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

(2013) Sarah D'Alessandro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Latest Developments in Assessing Antifungal Activity Using TLC-Bioautography: A Review

(2013) Quentin Favre-Godal et al.   JOURNAL OF AOAC INTERNATIONAL

Thiaplakortones A–D: Antimalarial Thiazine Alkaloids from the Australian Marine Sponge Plakortis lita

(2013) Rohan A. Davis et al.   JOURNAL OF ORGANIC CHEMISTRY

Automated Imaging and other developments in whole-organism anthelmintic screening

(2013) R. A. Paveley et al.   PARASITE IMMUNOLOGY

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

β-Secretase: its biology as a therapeutic target in diseases

(2013) Haibo Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

(2013) James S. Pham et al.   International Journal for Parasitology-Drugs and Drug Resistance

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.

(2012) Yunjiang Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Management of trypanosomiasis and leishmaniasis

(2012) M. P. Barrett et al.   BRITISH MEDICAL BULLETIN

Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms

(2012) R. M. Pruss   CNS & Neurological Disorders-Drug Targets

Cellular models to investigate biochemical pathways in Parkinson’s disease

(2012) Tiziana Alberio et al.   FEBS Journal

Neurodegenerative diseases: challenges and opportunities

(2012) Gregory D Cuny   Future Medicinal Chemistry

Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1

(2012) Kristina M. Orrling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Stress responses as determinants of antimicrobial resistance in Gram-negative bacteria

(2012) Keith Poole   TRENDS IN MICROBIOLOGY

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity

(2012) G Cisbani et al.   Cell Death & Disease

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

(2011) Sayaka Shibata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Validating a Firefly Luciferase-Based High-Throughput Screening Assay for Antimalarial Drug Discovery

(2011) Pulin Che et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa

(2011) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Early drug discovery and the rise of pharmaceutical chemistry

(2011) Alan Wayne Jones   Drug Testing and Analysis

Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads

(2011) Tyler A. Johnson et al.   JOURNAL OF NATURAL PRODUCTS

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

The use of multi-target drugs in the treatment of neurodegenerative diseases

(2011) Cornelis J Van der Schyf   Expert Review of Clinical Pharmacology

The beautiful cell: high-content screening in drug discovery

(2010) Marc Bickle   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death

(2010) Il Sang Yoon et al.   ANALYTICAL BIOCHEMISTRY

Potency determinations of acetylcholinesterase inhibitors using Ellman’s reaction-based assay in screening: Effect of assay variants

(2010) Päivi Järvinen et al.   ANALYTICAL BIOCHEMISTRY

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery. Edited by Taosheng Chen.

(2010) James Inglese   ChemMedChem

Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action

(2010) Alejandro M.S. Mayer et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Characteristics of known drug space. Natural products, their derivatives and synthetic drugs

(2010) Richard Bade et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial activity of essential oils: the possibilities of TLC-bioautography

(2010) Györgyi Horváth et al.   FLAVOUR AND FRAGRANCE JOURNAL

Neuroprotective strategies involving ROS in Alzheimer disease

(2010) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thin-layer chromatography with biological detection in phytochemistry

(2010) A. Marston   JOURNAL OF CHROMATOGRAPHY A

Bioautography detection in thin-layer chromatography

(2010) Irena M. Choma et al.   JOURNAL OF CHROMATOGRAPHY A

The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein Tau

(2010) Jeffrey R. Jones et al.   JOURNAL OF NATURAL PRODUCTS

A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration

(2010) L. C. Usher et al.   JOURNAL OF NEUROSCIENCE

Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharide-stimulated microglia cells

(2010) Jiyeon Ock et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Chagas disease

(2010) Anis Rassi et al.   LANCET

Comparison of Microscopy and Alamar Blue Reduction in a Larval Based Assay for Schistosome Drug Screening

(2010) Nuha R. Mansour et al.   PLoS Neglected Tropical Diseases

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

(2010) Isabel M. Vincent et al.   PLoS Pathogens

In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences

(2009) M. Vermeersch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro

(2009) Wen-Liang Chen et al.   BIOCHEMICAL PHARMACOLOGY

Antimicrobial Susceptibility Testing: A Review of General Principles and Contemporary Practices

(2009) James H. Jorgensen et al.   CLINICAL INFECTIOUS DISEASES

An in vitro screening cascade to identify neuroprotective antioxidants in ALS

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug repositioning usingin silicocompound profiling

(2009) Elodie Dubus et al.   Future Medicinal Chemistry

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil

(2009) M.S.A. Khan et al.   LETTERS IN APPLIED MICROBIOLOGY

Ongoing challenges in the management of malaria

(2009) Gilbert Kokwaro   MALARIA JOURNAL

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

High-Throughput Screening Platform for Anticancer Therapeutic Drug Cytotoxicity

(2008) Bhagwant Kaur Sekhon et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Medical biofilms

(2008) James D. Bryers   BIOTECHNOLOGY AND BIOENGINEERING

NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

(2008) M.A. Mena et al.   FEBS LETTERS

Flow cytometric assessment of the antimicrobial activity of essential oils against Listeria monocytogenes

(2008) Antonello Paparella et al.   FOOD CONTROL

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

(2008) Ahmed A Sayed et al.   NATURE MEDICINE

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Development of a High-Throughput Screening Assay for Chemical Effects on Proliferation and Viability of Immortalized Human Neural Progenitor Cells

(2008) Joseph M. Breier et al.   TOXICOLOGICAL SCIENCES