Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

Dynamic microglial modulation of spatial learning and social behavior

(2016) Luisa Torres et al.   BRAIN BEHAVIOR AND IMMUNITY

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control

(2016) Tina Djogo et al.   Cell Metabolism

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells

(2016) Sarah Schneider et al.   GLIA

Brain trauma elicits non-canonical macrophage activation states

(2016) Charles C. Kim et al.   Journal of Neuroinflammation

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter

(2015) F. Birey et al.   JOURNAL OF NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2

(2015) Fikri Birey et al.   NEURON

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer

(2015) Michelle L. Thompson et al.   PAIN

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

(2015) Bettina Schreiner et al.   Cell Reports

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

Abrogation of  -Catenin Signaling in Oligodendrocyte Precursor Cells Reduces Glial Scarring and Promotes Axon Regeneration after CNS Injury

(2014) J. P. Rodriguez et al.   JOURNAL OF NEUROSCIENCE

Function of microglia and macrophages in secondary damage after spinal cord injury

(2014) Yi Ren et al.   Neural Regeneration Research

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain

(2014) Leda Dimou et al.   PHYSIOLOGICAL REVIEWS

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia

(2014) Jerry Silver et al.   Cold Spring Harbor Perspectives in Biology

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

(2014) Simon Gritsch et al.   Nature Communications

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

Extensive regenerative plasticity among adult NG2-glia populations is exclusively based on self-renewal

(2013) Sarah C. Robins et al.   GLIA

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Connexin47 Protein Phosphorylation and Stability in Oligodendrocytes Depend on Expression of Connexin43 Protein in Astrocytes

(2013) D. May et al.   JOURNAL OF NEUROSCIENCE

Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafish CNS

(2013) Ah-Young Chung et al.   MOLECULES AND CELLS

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

Synaptic integration by NG2 cells

(2013) Wenjing Sun et al.   Frontiers in Cellular Neuroscience

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts

(2012) V. Chitu et al.   BLOOD

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair

(2012) F. Kaya et al.   JOURNAL OF NEUROSCIENCE

Targeted Ablation of Oligodendrocytes Induces Axonal Pathology Independent of Overt Demyelination

(2012) L.-J. Oluich et al.   JOURNAL OF NEUROSCIENCE

Primary oligodendrocyte death does not elicit anti-CNS immunity

(2012) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury

(2011) Christiane Simon et al.   GLIA

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Targeted Ablation of Oligodendrocytes Triggers Axonal Damage

(2011) Aniket Ghosh et al.   PLoS One

Excitability and Synaptic Communication within the Oligodendrocyte Lineage

(2010) L. M. De Biase et al.   JOURNAL OF NEUROSCIENCE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

(2010) Konstantina Psachoulia et al.   Neuron Glia Biology

Functions of Mature Mammalian Astrocytes: A Current View

(2010) Harold K. Kimelberg   NEUROSCIENTIST

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia

(2010) Nadine Jaenisch et al.   STROKE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

(2009) Isabelle Pineau et al.   BRAIN BEHAVIOR AND IMMUNITY

NG2+/Olig2+Cells are the Major Cycle-Related Cell Population of the Adult Human Normal Brain

(2009) Sameh Geha et al.   BRAIN PATHOLOGY

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Characteristics and functions of NG2 cells in normal brain and neuropathology

(2009) Anni Wang et al.   NEUROLOGICAL RESEARCH

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration

(2008) Angelo C. Lepore et al.   EXPERIMENTAL NEUROLOGY

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

(2008) G. Gowing et al.   JOURNAL OF NEUROSCIENCE

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA