Bioengineered kidney tubules efficiently excrete uremic toxins

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

(2016) Tom T. G. Nieskens et al.   AAPS Journal

Guanidinylations of albumin decreased binding capacity of hydrophobic metabolites

(2015) M. Rueth et al.   Acta Physiologica

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys

(2015) Melanie L. Lawrence et al.   Scientific Reports

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

(2015) J. Jansen et al.   Scientific Reports

Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis

(2015) Olivier Deltombe et al.   Toxins

Biotechnological challenges of bioartificial kidney engineering

(2014) J. Jansen et al.   BIOTECHNOLOGY ADVANCES

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue

(2014) J. Jansen et al.   EXPERIMENTAL CELL RESEARCH

Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure

(2014) Alberto Ortiz et al.   LANCET

Protein-Bound Molecules: A Large Family With a Bad Character

(2014) Tammy L. Sirich et al.   SEMINARS IN NEPHROLOGY

The Kidney and Uremic Toxin Removal: Glomerulus or Tubule?

(2014) Rosalinde Masereeuw et al.   SEMINARS IN NEPHROLOGY

Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models

(2014) Cynthia Van der Hauwaert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

15-Year Follow-up of a Multicenter, Randomized, Calcineurin Inhibitor Withdrawal Study in Kidney Transplantation

(2014) Joke I. Roodnat et al.   TRANSPLANTATION

Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)

(2013) Anita C.A. Dankers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Albumin is the main plasma binding protein for indoxyl sulfate andp-cresyl sulfate

(2013) Liesbeth Viaene et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Review of Protein-Bound Toxins, Possibility for Blood Purification Therapy

(2013) N. Neirynck et al.   BLOOD PURIFICATION

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall

(2013) A. Pletinck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p-Cresyl sulphate has pro-inflammatory and cytotoxic actions on human proximal tubular epithelial cells

(2013) Jonay Poveda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The bioartificial kidney: current status and future promise

(2013) H. David Humes et al.   PEDIATRIC NEPHROLOGY

Does the Adequacy Parameter Kt/Vurea Reflect Uremic Toxin Concentrations in Hemodialysis Patients?

(2013) Sunny Eloot et al.   PLoS One

Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production

(2012) Yoshiharu Itoh et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Indoxyl Sulfate Predicts Cardiovascular Disease and Renal Function Deterioration in Advanced Chronic Kidney Disease

(2012) Cheng-Jui Lin et al.   ARCHIVES OF MEDICAL RESEARCH

Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration

(2012) H.A.M. Mutsaers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innovative strategies in living donor kidney transplantation

(2012) Dorry L. Segev   Nature Reviews Nephrology

The anglerfish and uremic toxins

(2011) Jerome Lowenstein   FASEB JOURNAL

Human serum albumin: From bench to bedside

(2011) Gabriella Fanali et al.   MOLECULAR ASPECTS OF MEDICINE

Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3

(2011) Yuichi Uwai et al.   PHARMACOLOGICAL RESEARCH

Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

(2011) Henricus A. M. Mutsaers et al.   PLoS One

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Efficacy and Safety of Renal Tubule Cell Therapy for Acute Renal Failure

(2008) J. Tumlin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Bench to Bedside View of Uremic Toxins

(2008) R. Vanholder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY