In vitro models for liver toxicity testing

Immunosafety Evaluation of a Multilayer Flat-Plate Bioartificial Liver

(2011) Yue Zhang et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

A theoretical approach to zonation in a bioartificial liver

(2011) Adam J. Davidson et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel 3D liver organoid system for elucidation of hepatic glucose metabolism

(2011) Yanhua Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues

(2011) Fanny Evenou et al.   BIOTECHNOLOGY PROGRESS

Differentiation of human embryonic stem cells along a hepatic lineage

(2011) Stephanie M. Zamule et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Immune interactions in endometriosis

(2011) Jennifer L Herington et al.   Expert Review of Clinical Immunology

A Simple and economical route to generate functional hepatocyte-like cells from hESCs and their application in evaluating alcohol induced liver damage

(2011) Rajarshi Pal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracorporeal Liver Perfusion System for Artificial Liver Support Across a Membrane

(2011) Jai Bikhchandani et al.   JOURNAL OF SURGICAL RESEARCH

New advances in MR-compatible bioartificial liver

(2011) Rex E. Jeffries et al.   NMR IN BIOMEDICINE

Metabolic Profiling Based Quantitative Evaluation of Hepatocellular Metabolism in Presence of Adipocyte Derived Extracellular Matrix

(2011) Nripen S. Sharma et al.   PLoS One

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

(2011) M.G.L. Elferink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Future of liver transplantation: Non-human primates for patient-specific organs from induced pluripotent stem cells

(2011) Madhusudana Girija Sanal   WORLD JOURNAL OF GASTROENTEROLOGY

Development of a Bioartificial Liver with Sandwiched-Cultured Hepatocytes Between Two Collagen Gel Layers

(2010) Koichi Taguchi et al.   ARTIFICIAL ORGANS

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

(2010) Cheul Cho et al.   BIOTECHNIQUES

Engineering of an Hepatic Organoid to Develop Liver Assist Devices

(2010) Alejandro Soto-Gutierrez et al.   CELL TRANSPLANTATION

The Hepatocyte Suspension Assay Is Superior to the Cultured Hepatocyte Assay for Determining Mechanisms of Acetaminophen Hepatotoxicity Relevant toin VivoToxicity

(2010) Angela S. Burke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

(2010) Qin Meng   Expert Opinion on Drug Metabolism & Toxicology

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes

(2010) Hua Liu et al.   HEPATOLOGY

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

(2010) Benjamin D. Cosgrove et al.   Molecular BioSystems

Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells

(2010) Yuyou Duan et al.   STEM CELLS

Three-Dimensional Perfusion Bioreactor Culture Supports Differentiation of Human Fetal Liver Cells

(2010) Eva Schmelzer et al.   TISSUE ENGINEERING PART A

Tissue-Engineered Model for Real-Time Monitoring of Liver Inflammation

(2010) Rohit Jindal et al.   TISSUE ENGINEERING PART C-METHODS

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

(2010) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support

(2009) Eva Schmelzer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

(2009) Mark H. Chin et al.   Cell Stem Cell

Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes

(2009) K. Mathijs et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model

(2009) Rohit Jindal et al.   FASEB JOURNAL

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells

(2009) Petra Krause et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

(2009) Gabriella Brolén et al.   JOURNAL OF BIOTECHNOLOGY

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY

Transcriptional Signature and Memory Retention of Human-Induced Pluripotent Stem Cells

(2009) Maria C. N. Marchetto et al.   PLoS One

Working in partnership to advance the 3Rs in toxicity testing

(2009) Anthony M. Holmes et al.   TOXICOLOGY

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

(2009) Benjamin D. Cosgrove et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chitosan nanofiber scaffold enhances hepatocyte adhesion and function

(2008) Xue-Hui Chu et al.   BIOTECHNOLOGY LETTERS

Evolving concepts in liver tissue modeling and implications forin vitrotoxicology

(2008) André Guillouzo et al.   Expert Opinion on Drug Metabolism & Toxicology

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

(2008) Sadhana Agarwal et al.   STEM CELLS

Clozapine-induced hepatotoxicity in rat hepatocytes by gel entrapment and monolayer culture

(2008) Yanhua Lu et al.   TOXICOLOGY IN VITRO

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS