The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Wnts and the hallmarks of cancer

(2020) Zheng Zhong et al.   CANCER AND METASTASIS REVIEWS

The regulatory activity of autophagy in conjunctival fibroblasts and its possible role in vernal keratoconjunctivitis

(2020) Paola Brun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy

(2020) Verena Kohler et al.   Cells

Interplay Between Autophagy and Wnt/β-Catenin Signaling in Cancer: Therapeutic Potential Through Drug Repositioning

(2020) Carlos Pérez-Plasencia et al.   Frontiers in Oncology

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

(2020) Shahrokh Lorzadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo

(2019) Tomoaki Takai et al.   MOLECULAR THERAPY

Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

(2019) Xiawei Cheng et al.   MOLECULAR CELL

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

(2019) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

(2019) Qiancheng Jing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy as a molecular target for cancer treatment

(2019) Nur Mehpare Kocaturk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies

(2019) Larisa Ryskalin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy, cancer and angiogenesis: where is the link?

(2019) Bahareh Kardideh et al.   Cell and Bioscience

RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction

(2019) Xuanzhong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers

(2019) Yves Lecarpentier et al.   Frontiers in Oncology

Autophagy promotes triple negative breast cancer metastasis via YAP nuclear localization

(2019) Wei Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

(2019) Sonal Patel et al.   Frontiers in Immunology

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Enhanced glycolysis supports cell survival in EGFR-mutant lung adenocarcinoma by inhibiting autophagy-mediated EGFR degradation

(2018) Ji Hye Kim et al.   CANCER RESEARCH

Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells

(2018) Tara Miran et al.   FASEB JOURNAL

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

(2018) Qing Fan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

(2018) Tianxiao Gong et al.   Journal of Translational Medicine

Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms

(2018) Alexandre Vallée et al.   NEUROMOLECULAR MEDICINE

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

(2018) Yoonmi Lee et al.   Nature Communications

Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas

(2018) Alexandre Vallée et al.   Neuroscience Bulletin

Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression

(2018) Laura Brohée et al.   Scientific Reports

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

(2018) Alexandre Vallée et al.   Frontiers in Immunology

The role of YAP/TAZ activity in cancer metabolic reprogramming

(2018) Xiaodong Zhang et al.   Molecular Cancer

ULK1 negatively regulates Wnt signaling by phosphorylating Dishevelled

(2018) Sun-Hong Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells

(2018) Barbara Colella et al.   CELLULAR SIGNALLING

FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma

(2017) Lijuan Song et al.   EXPERIMENTAL CELL RESEARCH

Expression of enzymes related to glucose metabolism in non-small cell lung cancer and prognosis

(2017) Alexandra Giatromanolaki et al.   EXPERIMENTAL LUNG RESEARCH

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

(2017) Nicolas Aznar et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

(2017) Jianwei Liao et al.   Molecular Cancer

Wnt/β-catenin signaling pathway activation reverses gemcitabine resistance by attenuating Beclin1-mediated autophagy in the MG63 human osteosarcoma cell line

(2017) Hao Tao et al.   Molecular Medicine Reports

MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation

(2017) Liang Li et al.   ONCOLOGY RESEARCH

Vasculogenesis and angiogenesis initiation under normoxic conditions through Wnt/β-catenin pathway in gliomas

(2017) Alexandre Vallée et al.   REVIEWS IN THE NEUROSCIENCES

Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis

(2017) Alexandre Vallée et al.   Oncotarget

Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma

(2017) Alexandre Vallée et al.   Frontiers in Physiology

Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway

(2016) Moemi Kawaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

(2016) Kyle M. Loh et al.   DEVELOPMENTAL CELL

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer

(2016) Tao Liu et al.   ONCOLOGY REPORTS

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

New perspectives in glioblastoma antiangiogenic therapy

(2016) Alisa Madalina Popescu et al.   Wspolczesna Onkologia-Contemporary Oncology

Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

(2016) Valerie Le Sage et al.   Viruses-Basel

PI3K/Akt promotes feedforward mTORC2 activation through IKKα

(2016) Han C. Dan et al.   Oncotarget

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma

(2016) Alexandre Vallée et al.   Frontiers in Neuroscience

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis

(2016) Yves Lecarpentier et al.   Frontiers in Neurology

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

(2015) Ana Maria Marques Orellana et al.   Aging-US

Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells

(2015) Yunus Akkoç et al.   BIOMEDICINE & PHARMACOTHERAPY

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Synergy in activating class I PI3Ks

(2015) John E. Burke et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

(2015) Chunxia Li et al.   World Journal of Surgical Oncology

Autophagy in lung disease pathogenesis and therapeutics

(2015) Stefan W. Ryter et al.   Redox Biology

Autophagy and mammalian development

(2015) Xiaoting Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

(2015) Keita Shibuya et al.   Oncotarget

Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status

(2014) Annan Yang et al.   Autophagy

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease

(2014) Richard A. Harris et al.   BIOGERONTOLOGY

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells

(2014) Haili Wu et al.   CELLULAR SIGNALLING

Wnt meets Warburg: another piece in the puzzle?

(2014) C. B. Thompson   EMBO JOURNAL

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction

(2014) Yves Lecarpentier et al.   Frontiers in Physiology

Nutrients and growth factors in mTORC1 activation

(2013) Alejo Efeyan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Lactate-Modulated Induction of THBS-1 Activates Transforming Growth Factor (TGF)-beta2 and Migration of Glioma Cells In Vitro

(2013) Corinna Seliger et al.   PLoS One

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis

(2013) John R. Haaga et al.   SURGERY

Wnt your brain be inflamed? Yes, it Wnt!

(2013) Bianca Marchetti et al.   TRENDS IN MOLECULAR MEDICINE

Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding

(2013) Arshawn Sami et al.   TUMOR BIOLOGY

Oxygen metabolism in oral cancer: HIF and GLUTs (Review)

(2013) KARUZA MARIA ALVES PEREIRA et al.   Oncology Letters

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice

(2012) Paolo E. Porporato et al.   ANGIOGENESIS

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

(2012) D. J. Goussetis et al.   BLOOD

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting the EGFR signaling pathway in cancer therapy

(2012) Parthasarathy Seshacharyulu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Availability, not respiratory capacity governs oxygen consumption of solid tumors

(2012) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-catenin and its Diverse Physiological Cell Signaling Pathways in Neurodegenerative and Neuropsychiatric Disorders

(2012) Lena Al-Harthi   Journal of Neuroimmune Pharmacology

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

(2012) Nibaldo C. Inestrosa et al.   Journal of Neuroimmune Pharmacology

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K regulation of the SKP-2/p27 axis through mTORC2

(2012) K Shanmugasundaram et al.   ONCOGENE

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

(2012) G Sutendra et al.   ONCOGENE

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

(2012) Kristin K. Ambacher et al.   PLoS One

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

(2011) Gabriele D Maurer et al.   BMC CANCER

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PI3-K and GSK-3: Akt-ing together with microtubules

(2011) Graham J. Buttrick et al.   CELL CYCLE

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

(2011) M. I. Koukourakis et al.   CLINICAL CANCER RESEARCH

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner

(2011) Jon M. Carthy et al.   PLoS One

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PI3K and STAT3: A New Alliance

(2011) P. K. Vogt et al.   Cancer Discovery

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Activated STAT3 Regulates Hypoxia-Induced Angiogenesis and Cell Migration in Human Glioblastoma

(2010) Shin-Hyuk Kang et al.   NEUROSURGERY

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of hyaluronan in angiogenesis and its utility to angiogenic tissue engineering

(2010) Erin L. Pardue et al.   Organogenesis

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions for substrate recognition

(2009) Elaine A. Dunlop et al.   CELLULAR SIGNALLING

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells

(2009) Gwenny M. Fuhler et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

(2009) Maria Cristina Rosi et al.   JOURNAL OF NEUROCHEMISTRY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Glycolytic metabolism and tumour response to fractionated irradiation

(2009) Ulrike G.A. Sattler et al.   RADIOTHERAPY AND ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma

(2008) Shuang Yan et al.   CANCER LETTERS

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hyaluronan and Human Endothelial Cell Behavior

(2008) Anna Genasetti et al.   CONNECTIVE TISSUE RESEARCH

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate Stimulates Vasculogenic Stem Cells via the Thioredoxin System and Engages an Autocrine Activation Loop Involving Hypoxia-Inducible Factor 1

(2008) T. N. Milovanova et al.   MOLECULAR AND CELLULAR BIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Wnt-fall for Gene Regulation: Repression

(2008) N. P. Hoverter et al.   Science Signaling

Hyaluronidases in cancer biology

(2008) Robert Stern   SEMINARS IN CANCER BIOLOGY