Article
Oncology
Yujiao Zhang, Yizeng Fan, Xin Jing, Lin Zhao, Tianjie Liu, Lu Wang, Lifen Zhang, Shanzhi Gu, Xinhan Zhao, Yan Teng
Summary: Studies have shown that the activation of YAP increases macrophage recruitment, but its role in macrophage polarization, especially in TNBC progression, is still unclear. TNBC cells were found to increase YAP expression in macrophages via OTUD5-mediated deubiquitination and stabilization, leading to polarization towards the M2-like phenotype. Additionally, high expression of YAP in M2-like macrophages was associated with pro-metastatic potential of TNBC cells through the MCP-1/CCR2 pathway, and negatively related to survival. This suggests that targeting YAP(+) M2 macrophages could be a novel therapeutic strategy for TNBC treatment.
Article
Oncology
Samson Mugisha, Xiaotang Di, Doudou Wen, Yuetao Zhao, Xusheng Wu, Shubing Zhang, Hao Jiang
Summary: This study uncovers a novel GATA3/miR205-5p/MFNG feed-forward loop as a potential therapeutic target for triple-negative breast cancer (TNBC), which plays a crucial role in inhibiting cell migration and tumor growth.
Article
Oncology
Dong Li, Hami Hemati, Younhee Park, Rokana Taftaf, Youbin Zhang, Jinpeng Liu, Massimo Cristofanilli, Xia Liu
Summary: The study reveals that ICAM-1 on TNBC cells and CD11b on neutrophils play a role in the binding between tumor cells and neutrophils, and CD11b mediates hydrogen peroxide production. Additionally, ICAM-1 in TNBC cells promotes the secretion of suPAR, which negatively affects the survival of breast cancer patients. Therefore, targeting the ICAM-1-suPAR-CD11b axis could be a potential therapeutic strategy for inhibiting TNBC metastasis.
Article
Oncology
Huijie Yang, Min Xue, Peng Su, Yan Zhou, Xin Li, Zhongbo Li, Yan Xia, Chenmiao Zhang, Mingxi Fu, Xiuxia Zheng, Guosheng Luo, Tian Wei, Xinxing Wang, Yinlu Ding, Jian Zhu, Ting Zhuang
Summary: In this study, the tumor-suppressive function of RNF31 in triple negative breast cancer (TNBC) was demonstrated. It was found that RNF31 could regulate the Hippo signaling pathway and its depletion increased TNBC cell proliferation and migration. Clinical data also showed that RNF31 expression was correlated with longer relapse-free survival in TNBC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hye Min Kim, Ja Seung Koo
Summary: Patient morbidity and mortality are significantly increased in metastatic breast cancer. The metastasis process of breast cancer is very complicated and controlled by various factors. Autophagy is an important regulatory factor affecting metastasis in breast cancer, involving cell mobility, metabolic adaptation, tumor dormancy, and cancer stem cells. In this article, we discuss the effects of autophagy on breast cancer metastasis and evaluate the potential use of autophagy modulators for metastasis treatment.
Article
Chemistry, Multidisciplinary
Ting Jiang, Jiaojiao Zhu, Shilong Jiang, Zonglin Chen, Ping Xu, Rong Gong, Changxin Zhong, Yueying Cheng, Xinyuan Sun, Wenjun Yi, Jinming Yang, Wenhu Zhou, Yan Cheng
Summary: In this study, it is discovered that the lncRNA DDIT4-AS1 is highly expressed in TNBC and promotes its progression and chemoresistance by activating autophagy. Mechanistically, DDIT4-AS1 stabilizes DDIT4 mRNA and inhibits the mTOR signaling pathway. Silencing DDIT4-AS1 enhances sensitivity to chemotherapy, and using a self-activatable siRNA/drug nanoparticle system improves antitumor activity. Targeting DDIT4-AS1 may be a new therapeutic approach for TNBC.
Article
Pharmacology & Pharmacy
Lai Jin, Tiantian Li, Yali Hong, Rongchen Mao, Li Xu, Chao Zhu, Junyu Mu, Jun Zhou, Lihua Pan, Yuhui Que, Yidong Xia, Yuheng Zhang, Shengnan Li
Summary: Nucleotide-binding oligomerization domain (NOD)-like receptor type 2 protein (NLRP2) inhibits NF-KB in breast cancer metastasis and is positively correlated with survival rate and negatively correlated with metastasis potential. Re-expression of NLRP2 inhibits growth and metastasis of TNBC xenograft model. NLRP2 modulates hnRNPK and could be a biomarker for TNBC chemotherapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Jianxin Xu, Xuejiao Fang, Luye Long, Sixuan Wang, Shihan Qian, Jianxin Lyu
Summary: This study found that HMGA2 is highly expressed in TNBC cells, and downregulation of HMGA2 inhibits the migration and invasion of TNBC, as well as tumor metastasis in vivo, through suppression of EMT and the Hippo-YAP pathway.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Toosendanin (TSN) and isotoosendanin (ITSN) are natural triterpenoids that inhibit the growth of triple-negative breast cancer (TNBC) by inducing necrosis, apoptosis, and autophagy in tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu, Ting Zhuang
Summary: Our study revealed an opposite function of RBCK1 in TNBC progression. By enhancing the stability of YAP protein through promoting its poly-ubiquitination, RBCK1 could inhibit the proliferation and invasion of TNBC cells, providing a promising new target for TNBC treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang
Summary: This study found that hypoxia-induced HIF-1 alpha upregulated C1QBP, which when inhibited, notably blocked the metastasis of TNBC cells and increased their sensitivity to PTX under hypoxic conditions. Depletion of C1QBP decreased VCAM-1 expression by reducing the amount of P65 in the nucleus and suppressed the activation of hypoxia-induced PKC-NF-kappa B signaling. Targeting C1QBP along with PTX treatment could be a potential treatment for TNBC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
John W. W. Weaver, Jinyu Zhang, Juan Rojas, Phillip R. R. Musich, Zhiqiang Yao, Yong Jiang
Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks well-defined molecular targets. Exosomes play an important role in the tumorigenesis and treatment of TNBC, serving as biomarkers for diagnosis, monitoring, and treatment, as well as a nanosized drug-delivery system.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Medicinal
Dong-Lin Yang, Ya-Jun Zhang, Jie Lei, Shi-Qiang Li, Liu-Jun He, Dian-Yong Tang, Chuan Xu, Ling-Tian Zhang, Jingyuan Wen, Hui-Kuan Lin, Hong-yu Li, Zhong-Zhu Chen, Zhi-Gang Xu
Summary: Compound 7h, identified through screening and optimization process, showed potent activity against TNBC cells by inhibiting autophagic flux and inducing degradation of HR-related proteins. It has the potential to be developed as an anti-cancer therapeutic for TNBC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Shao-Ying Yang, Yi-Fan Xie, Tai-Mei Zhang, Ling Deng, Li Liao, Shu-Yuan Hu, Yin-Ling Zhang, Fang-Lin Zhang, Da-Qiang Li
Summary: This study reports the upregulation of IMPA1 in TNBC and its role in proliferation, metastasis and tumor formation in TNBC cells. Transcriptome sequencing analysis reveals that IMPA1 induces mTOR activity and epithelial-mesenchymal transition (EMT) process, thus promoting TNBC progression.
Article
Chemistry, Medicinal
Jia Wang, Ping Huang, Xiafang Pan, Chunhua Xia, Hong Zhang, Han Zhao, Zhao Yuan, Jianming Liu, Chao Meng, Fanglan Liu
Summary: Resveratrol inhibits tumor cell proliferation and growth, and suppresses invasion and pulmonary metastasis of breast cancer. It exerts its anticancer effects through the SIRT3/AMPK/autophagy pathway.
PHYTOTHERAPY RESEARCH
(2023)
Review
Health Care Sciences & Services
Caitlin McArthur, Yuxin Bai, Patricia Hewston, Lora Giangregorio, Sharon Straus, Alexandra Papaioannou
Summary: This review synthesized barriers and facilitators to implementing evidence-based guidelines in long-term care, with barriers including time constraints, inadequate staffing, and lack of resources, and facilitators including leadership and champions, well-designed strategies and resources. Long-term care staff identified physical and social opportunity and psychological capability as the most important components of the Behaviour Change Wheel.
IMPLEMENTATION SCIENCE
(2021)
Article
Multidisciplinary Sciences
Wei Chen, Shihyun Park, Chrishma Patel, Yuxin Bai, Karim Henary, Arjun Raha, Saeed Mohammadi, Lidan You, Fei Geng
Summary: Matrix stiffness influences the proliferation and migration ability of breast cancer cells, with YAP playing a significant role in this process. As matrix stiffness increases, highly metastatic breast cancer cells exhibit a different migratory potential compared to non-metastatic cells, and this process is YAP-dependent.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)