PI3K regulation of the SKP-2/p27 axis through mTORC2

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis

(2012) Veronique Nogueira et al.   EMBO JOURNAL

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

(2011) Christel Boutonnet et al.   CELL CYCLE

A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1

(2011) Hongbo Wang et al.   CELL CYCLE

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

(2011) Tarig Bashir et al.   CELL CYCLE

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion and metastasis

(2011) E K Kim et al.   ONCOGENE

Loss of nuclear p27kip1 and α-dystroglycan is a frequent event and is a strong predictor of poor outcome in renal cell carcinoma

(2010) Alessandro Sgambato et al.   CANCER SCIENCE

The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma

(2010) D. C. Cho et al.   CLINICAL CANCER RESEARCH

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

(2010) Irantzu Tato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

(2009) David A. Guertin et al.   CANCER CELL

Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors

(2009) J. Huang et al.   CANCER RESEARCH

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

(2008) P. C. McDonald et al.   CANCER RESEARCH

Post-translational regulation of the tumor suppressor p27KIP1

(2008) J. Vervoorts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytoplasmic Sequestration of p27 via AKT Phosphorylation in Renal Cell Carcinoma

(2008) J. Kim et al.   CLINICAL CANCER RESEARCH

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study

(2008) Zheng Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY