Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

(2015) Alex J. Bott et al.   Cell Metabolism

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

A growing role for mTOR in promoting anabolic metabolism

(2013) Jessica J. Howell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amot130 Adapts Atrophin-1 Interacting Protein 4 to Inhibit Yes-associated Protein Signaling and Cell Growth

(2013) Jacob J. Adler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Waste Nitrogen Metabolism and Excretion in Zebrafish Embryos: Effects of Light, Ammonia, and Nicotinamide

(2013) CAROL BUCKING et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases

(2013) J. J. Adler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

(2012) Eric Miller et al.   CHEMISTRY & BIOLOGY

Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene

(2012) Christian J. Gaffney et al.   GENE

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Incorporating RNA-seq data into the zebrafish Ensembl genebuild

(2012) J. E. Collins et al.   GENOME RESEARCH

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

(2012) Giorgio Giacomo Galli et al.   PLoS Genetics

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Deregulation of Hippo kinase signalling in Human hepatic malignancies

(2011) Hua Li et al.   LIVER INTERNATIONAL

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma

(2011) Andreas Schmidt et al.   TOXICOLOGY

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

An efficient DNA isolation protocol for filamentous cyanobacteria of the genus Arthrospira

(2009) Nicolas Morin et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

(2008) Wolfram Goessling et al.   DEVELOPMENTAL BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT