Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells

(2010) Alfredo Toschi et al.   CANCER LETTERS

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways

(2010) Klaus Podar et al.   CELL CYCLE

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

(2010) Andrew Y. Choo et al.   MOLECULAR CELL

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

(2010) A. Moritz et al.   Science Signaling

An Essential Role of the HIF-1α-c-Myc Axis in Malignant Progression

(2009) Young-Gun Yoo et al.   Annals of the New York Academy of Sciences

Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

(2009) Marie-José Blouin et al.   CANCER LETTERS

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

(2009) Gilles A. Spoden et al.   EXPERIMENTAL CELL RESEARCH

A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles

(2009) Kristen Pollizzi et al.   HUMAN MOLECULAR GENETICS

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

(2008) John J. Bissler et al.   NEW ENGLAND JOURNAL OF MEDICINE

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

(2008) C B Knobbe et al.   ONCOGENE

The role of PTEN signaling perturbations in cancer and in targeted therapy

(2008) M Keniry et al.   ONCOGENE