Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway

(2016) Ge Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway

(2015) Boli Hu et al.   Autophagy

Respiratory syncytial virus induces phosphorylation of mTOR at ser2448 in CD8 T cells from nasal washes of infected infants

(2015) A. P. Duarte de Souza et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38

(2015) Yadan Bai et al.   JOURNAL OF VIROLOGY

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

(2015) Bastian Thaa et al.   JOURNAL OF VIROLOGY

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

(2015) Lifang Zhang et al.   Molecular Cancer

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5′-TOP mRNAs restricts viral infection

(2015) Kaycie C. Hopkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

(2015) Masahiro Shuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

(2015) Alonso Heredia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E as a Control Target for Viruses

(2015) Hilda Montero et al.   Viruses-Basel

Autophagy restricts HIV-1 infection

(2015) Coralie F. Daussy et al.   Oncotarget

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

(2015) Pierre-Emmanuel Joubert et al.   PLoS Pathogens

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

(2015) Benjamin Rauwel et al.   eLife

Coxsackievirus A16 Elicits Incomplete Autophagy Involving the mTOR and ERK Pathways

(2015) Yingying Shi et al.   PLoS One

Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways

(2015) Wei-Ru Huang et al.   PLoS One

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients

(2014) Roberta Nardacci et al.   Autophagy

A unique phosphorylation-dependent eIF4E assembly on 40S ribosomes co-ordinated by hepatitis C virus protein NS5A that activates internal ribosome entry site translation

(2014) Swarupa Panda et al.   BIOCHEMICAL JOURNAL

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Antiviral Autophagy Restricts Rift Valley Fever Virus Infection and Is Conserved from Flies to Mammals

(2014) Ryan H. Moy et al.   IMMUNITY

Roles of autophagy in HIV infection

(2014) Christina Dinkins et al.   IMMUNOLOGY AND CELL BIOLOGY

West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression

(2014) K. D. Shives et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Promotes the Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma via Metastatic Tumor Antigen 1 and Mechanistic Target of Rapamycin Signaling Induction

(2014) Z. Lin et al.   JOURNAL OF VIROLOGY

Hijacking Dlg1 for Oncogenic Phosphatidylinositol 3-Kinase Activation in Human Epithelial Cells Is a Conserved Mechanism of Human Adenovirus E4-ORF1 Proteins

(2014) M. Kumar et al.   JOURNAL OF VIROLOGY

Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during Infection

(2014) Indrani Das et al.   PLoS One

mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection

(2014) Emmanuel Datan et al.   VIROLOGY

The Human Adenovirus E4-ORF1 Protein Subverts Discs Large 1 to Mediate Membrane Recruitment and Dysregulation of Phosphatidylinositol 3-Kinase

(2014) Kathleen Kong et al.   PLoS Pathogens

Nutrients and growth factors in mTORC1 activation

(2013) Alejo Efeyan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Merkel Cell Polyomavirus–Positive Merkel Cell Carcinoma Requires Viral Small T-Antigen for Cell Proliferation

(2013) Masahiro Shuda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway

(2013) Irina N. Gavrilovskaya et al.   JOURNAL OF VIROLOGY

Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene

(2013) D Martin et al.   ONCOGENE

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

(2012) He Huang et al.   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells

(2012) A. J. Clippinger et al.   GENES & DEVELOPMENT

Chikungunya virus–induced autophagy delays caspase-dependent cell death

(2012) Pierre-Emmanuel Joubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrin  1 Mediates Vaccinia Virus Entry through Activation of PI3K/Akt Signaling

(2012) R. Izmailyan et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Activates the mTOR/S6K1 Signaling Pathway in Inhibiting IRS-1 Function for Insulin Resistance

(2012) S. K. Bose et al.   JOURNAL OF VIROLOGY

Role for the Phosphatidylinositol 3-Kinase-Akt-TOR Pathway during Sindbis Virus Replication in Arthropods

(2012) R. K. Patel et al.   JOURNAL OF VIROLOGY

Porcine Circovirus Type 2 Induces Autophagy via the AMPK/ERK/TSC2/mTOR Signaling Pathway in PK-15 Cells

(2012) B. Zhu et al.   JOURNAL OF VIROLOGY

The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism

(2012) M. D. Urbanowski et al.   JOURNAL OF VIROLOGY

Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway during Porcine Circovirus Type 2 Infection Facilitates Cell Survival and Viral Replication

(2012) L. Wei et al.   JOURNAL OF VIROLOGY

Host mTORC1 Signaling Regulates Andes Virus Replication

(2012) S. McNulty et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

Proteomic Analysis of Chikungunya Virus Infected Microgial Cells

(2012) Bizunesh Abere et al.   PLoS One

West Nile Virus (WNV) Replication Is Independent of Autophagy in Mammalian Cells

(2012) Rianna Vandergaast et al.   PLoS One

West Nile virus growth is independent of autophagy activation

(2012) Erica Beatman et al.   VIROLOGY

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells

(2011) Vidyarani Mohankumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

A herpesvirus kinase that masquerades as Akt

(2011) Uyanga Chuluunbaatar et al.   CELL CYCLE

Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation

(2011) Anju George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

(2011) Masahiro Shuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Cytomegalovirus Infection Maintains mTOR Activity and Its Perinuclear Localization during Amino Acid Deprivation

(2011) A. J. Clippinger et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species

(2011) C. Tilton et al.   JOURNAL OF VIROLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Porcine circovirus type 2 explores the autophagic machinery for replication in PK-15 cells

(2011) Binglin Zhu et al.   VIRUS RESEARCH

Potential use of rapamycin in HIV infection

(2010) Marco Donia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

(2010) U. Chuluunbaatar et al.   GENES & DEVELOPMENT

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses

(2010) Fabien P. Blanchet et al.   IMMUNITY

Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR

(2010) Lu Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Manipulation of the Akt Signaling Pathway Regulates Myxoma Virus Replication and Tropism in Human Cancer Cells

(2010) S. J. Werden et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol 3-Kinase-, Actin-, and Microtubule-Dependent Transport of Semliki Forest Virus Replication Complexes from the Plasma Membrane to Modified Lysosomes

(2010) P. Spuul et al.   JOURNAL OF VIROLOGY

Dominant Inhibition of Akt/Protein Kinase B Signaling by the Matrix Protein of a Negative-Strand RNA Virus

(2010) E. F. Dunn et al.   JOURNAL OF VIROLOGY

The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis

(2010) J. M. Spangle et al.   JOURNAL OF VIROLOGY

mTORC1 signaling: what we still don't know

(2010) X. Wang et al.   Journal of Molecular Cell Biology

Autophagy proteins promote hepatitis C virus replication

(2009) Marlène Dreux et al.   Autophagy

Autophagy is involved in influenza A virus replication

(2009) Zhi Zhou et al.   Autophagy

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Role of AKT Kinase in Measles Virus Replication

(2009) M. Carsillo et al.   JOURNAL OF VIROLOGY

Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication

(2009) J. A. P. Soares et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Protein pUL38 Induces ATF4 Expression, Inhibits Persistent JNK Phosphorylation, and Suppresses Endoplasmic Reticulum Stress-Induced Cell Death

(2009) B. Xuan et al.   JOURNAL OF VIROLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy

(2008) Dexin Kong et al.   CANCER SCIENCE

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex

(2008) Nathaniel J. Moorman et al.   Cell Host & Microbe

E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6

(2008) Li Zheng et al.   GENES TO CELLS

Host immunity during RSV pathogenesis

(2008) Susan M. Bueno et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Eukaryotic Translation Initiation Factor 4F Architectural Alterations Accompany Translation Initiation Factor Redistribution in Poxvirus-Infected Cells

(2008) D. Walsh et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE