Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

Vascular Hypoxic Preconditioning Relies on TRPV4-Dependent Calcium Influx and Proper Intercellular Gap Junctions Communication

(2012) Géraldine Rath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Antiproliferative Activity of TGF 

(2011) A. K.-v. Ameln et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

(2011) C. Ladroue et al.   HAEMATOLOGICA

The therapeutic potential of ischemic conditioning: an update

(2011) Derek J. Hausenloy et al.   Nature Reviews Cardiology

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

PHD2 in tumour angiogenesis

(2010) D A Chan et al.   BRITISH JOURNAL OF CANCER

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

Identification of Cyclooxygenase-2 as a Major Actor of the Transcriptomic Adaptation of Endothelial and Tumor Cells to Cyclic Hypoxia: Effect on Angiogenesis and Metastases

(2010) G. Daneau et al.   CLINICAL CANCER RESEARCH

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Challenges in Pharmacotherapy of Neoplastic Diseases – The Search for Addictions

(2010) Olivier Feron   Frontiers in Pharmacology

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide

(2009) Victor M. Victor et al.   CIRCULATION RESEARCH

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

Nitric oxide delivery to cancer: Why and how?

(2009) Pierre Sonveaux et al.   EUROPEAN JOURNAL OF CANCER

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia

(2009) Eleftheria Hatzimichael et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

(2009) J.-L. Balligand et al.   PHYSIOLOGICAL REVIEWS

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

Premature senescence of human endothelial cells induced by inhibition of glutaminase

(2008) Hermann Unterluggauer et al.   BIOGERONTOLOGY