Article
Pharmacology & Pharmacy
Mengxin Li, Xuyang Chen, Xuanzhong Wang, Xiaodong Wei, Ding Wang, Xiaorui Liu, Libo Xu, Wuren Batu, Yang Li, Baofeng Guo, Ling Zhang
Summary: The study demonstrated that RSL3 improved the sensitivity of PCa to DDP by causing glycolysis dysfunction, effectively inhibiting PCa cell proliferation both in vitro and in vivo. Additionally, cotreatment of RSL3 and DDP could alleviate apoptosis and cell cycle abnormalities in PCa cells, providing a potential therapeutic strategy for PCa.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Yi Feng, Jubo Wang, Bing Cai, Ximin Bai, Yiru Zhu
Summary: The study found that IVM accelerates autophagic death of glioma cells by inhibiting glycolysis and promoting autophagy, possibly through blocking the GLUT4-mediated JAK/STAT signaling pathway activation.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Tian Liu, Yubing Wang, Yiwei Wang, Stanley Kwok-Kuen Cheung, Penelope Mei-Yu Or, Chi-Wai Wong, Jingyu Guan, Zhining Li, Weiqin Yang, Yalin Tu, Jing Wang, Wayne Lut-Heng Ho, Haiwei Gu, Alfred Sze-Lok Cheng, Stephen Kwok-Wing Tsui, Andrew M. Chan
Summary: Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module associated with poor prognosis and aggressiveness of glioma. Within this module, Regulator of chromatin condensation 2 (RCC2) serves as a core member and plays a vital role in the mitotic process. Abnormal RCC2 expression is involved in cancer development. Gene silencing experiments confirm the importance of RCC2 in glioma cell proliferation and migration. RNA-Sequencing analysis reveals that RCC2 has a dual role in the cell cycle and metabolism.
Article
Medicine, Research & Experimental
Jingshan Liang, Changtao Liu, Dezhi Xu, Kang Xie, Aimin Li
Summary: This study found that the long noncoding RNA NEAT1 promotes glioma progression by stabilizing PGK1. Overexpression of NEAT1 is associated with poor overall survival in GBM patients, indicating that the NEAT1/PGK1 axis may be a candidate therapeutic target for glioma treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Longzhou Zhang, Zengjin Liu, Yang Dong, Lingchang Kong
Summary: The study elucidated that E2F2 plays a crucial role in glioma malignancy progression by transcriptionally enhancing PFKFB4 expression and activating the PI3K/AKT pathway. Inhibition of E2F2 suppressed glioma growth and metastasis, indicating its potential as a therapeutic target.
Review
Chemistry, Medicinal
Haoyang Huang, Qing He, Binghua Guo, Xudong Xu, Yinjuan Wu, Xuerong Li
Summary: Drug repurposing is a feasible strategy in developing novel medications, and antiparasitic drugs have shown potential in cancer treatment with diverse mechanisms. Further exploration in clinical trials and modifications in drug delivery systems or combinations are recommended for future research.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Xiangying Luo, Jianwei Ge, Tao Chen, Jinfang Liu, Ziyuan Liu, Changlong Bi, Song Lan
Summary: The study observed decreased LHX9 expression in glioma tissues, with upregulation inhibiting cell growth and interacting with p53. Downregulation of LHX9 promoted PGK1 expression, accelerating glioma development.
Article
Biochemistry & Molecular Biology
Xin Chen, Na Sun, Rongqin Li, Xuejia Sang, Xueqin Li, Jie Zhao, Jing Han, Jing Yang, Takayuki Ikezoe
Summary: HLA-F, overexpressed in glioma tissues, promotes cell proliferation and predicts recurrence, while facilitating cell growth through HK2-dependent glycolysis. Thus, HLA-F could be a potential therapeutic target for the treatment of glioma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ningning Zhao, Jiajie Zhang, Qian Zhao, Chao Chen, Huijuan Wang
Summary: Glioma is a common and aggressive brain tumor with poor prognosis due to uncontrolled proliferation and metabolic reprogramming. Long noncoding RNAs play diverse roles in shaping the biological features of glioma, but more research is needed to fully understand their mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Kevin Cornett, Anna Puderbaugh, Olivia Back, Rolf Craven
Summary: Neuroblastoma is a pediatric cancer that relies on glycolysis for energy and metabolites. The central enzyme GAPDH plays a diverse role in metabolism, including glucose uptake and iron uptake. This review discusses the potential implications of these activities in cancer metabolism, treatment, and drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sajid Jalal, Ting Zhang, Jia Deng, Jie Wang, Ting Xu, Tianhua Zhang, Chuanxin Zhai, Ruqiang Yuan, Hongming Teng, Lin Huang
Summary: This study found that LXX-8250 treatment can induce apoptosis in melanoma cells by inhibiting autophagic flux and glycolysis. This effect is mediated by suppression of PFKFB4 expression. The research provides a novel strategy for the treatment of melanoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Shupeng Li, Ziwei Li, Xinyu Wang, Junzhe Zhong, Daohan Yu, Hao Chen, Wenbin Ma, Lingling Liu, Minghuang Ye, Ruofei Shen, Chuanlu Jiang, Xiangqi Meng, Jinquan Cai
Summary: The study revealed that HK3 significantly promotes immune cell infiltration in glioma, and its expression level is closely related to tumor grade and prognosis.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Zhaoyuan Meng, Xueli Bian, Leina Ma, Gang Zhang, Qingxia Ma, Qianqian Xu, Juanjuan Liu, Runze Wang, Jie Lun, Qian Lin, Gaoxiang Zhao, Hongfei Jiang, Wensheng Qiu, Jing Fang, Zhimin Lu
Summary: In this study, it was found that key glycolytic enzyme phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) can interact with SUMO-conjugating enzyme UBC9 and be SUMOylated in glioblastoma cells. Activation of EGFR increases the interaction between UBC9 and PFKFB3, leading to increased SUMOylation and expression of PFKFB3. These findings reveal a previously unknown mechanism underlying the regulation of the Warburg effect through EGFR activation-induced and UBC9-mediated SUMOylation and stabilization of PFKFB3.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Review
Cell Biology
Kexin Zhang, Lixue Sun, Yuanyuan Kang
Summary: PGK1 plays a significant role in cancer, and its structure, function, and molecular mechanisms are involved in the regulation of cancer initiation and progression. It is also associated with chemotherapy resistance and prognosis in cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ana M. Cardoso, Catarina M. Morais, Olinda Rebelo, Herminio Tao, Marcos Barbosa, Maria C. Pedroso de Lima, Amalia S. Jurado
Summary: The silencing of lncRNA-MVIH may reduce glycolysis, cell growth, migration, and invasion in human GB cells, and sensitize them to cediranib. The study suggests a new mechanism of action for lncRNA-MVIH as a sponge for miR-302a, indicating its potential as a promising strategy to address invasiveness and chemoresistance in GB.
HUMAN MOLECULAR GENETICS
(2021)
Correction
Oncology
Ye Ding, Chuan He, Shan Lu, Xuanzhong Wang, Chongcheng Wang, Lei Wang, Ji Zhang, Meihua Piao, Guangfan Chi, Yinan Luo, Ke Sai, Pengfei Ge
Article
Oncology
Mengxin Li, Xuanzhong Wang, Shan Lu, Chuan He, Chongcheng Wang, Lei Wang, Xinyu Wang, Pengfei Ge, Dong Song
Article
Cell Biology
Chongcheng Wang, Chuan He, Shan Lu, Xuanzhong Wang, Lei Wang, Shipeng Liang, Xinyu Wang, Meihua Piao, Jiayue Cui, Guangfan Chi, Pengfei Ge
CELL DEATH & DISEASE
(2020)
Review
Oncology
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge
Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chuan He, Shan Lu, Xuan-zhong Wang, Chong-cheng Wang, Lei Wang, Shi-peng Liang, Tian-fei Luo, Zhen-chuan Wang, Mei-hua Piao, Guang-fan Chi, Peng-fei Ge
Summary: The study demonstrates that FOXO3a attenuates temozolomide-induced DNA double strand breaks in human glioma cells by promoting BNIP3-mediated mitophagy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Shan Lu, Xuan-zhong Wang, Chuan He, Lei Wang, Shi-peng Liang, Chong-cheng Wang, Chen Li, Tian-fei Luo, Chun-sheng Feng, Zhen-chuan Wang, Guang-fan Chi, Peng-fei Ge
Summary: The study demonstrates that brucine inhibits glioma cell growth and induces ferroptosis by promoting the accumulation of H2O2 and iron via activation of ATF3.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Biotechnology & Applied Microbiology
Tianyi Liu, Wenhao Zhu, Xiaoyu Zhang, Chuan He, Xiaolong Liu, Qiang Xin, Kexin Chen, Haifeng Wang
Summary: Spinal cord injury (SCI) is a devastating disease that causes sensory and motor function loss. Cell transplantation combined with functional biomaterials can provide neuroprotective and regenerative effects by regulating cell differentiation and providing support for axon regeneration.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Long Gu, Xueqi Pan, Chongcheng Wang, Lei Wang
Summary: Anesthetics are necessary for cancer surgery, but some of them have been proven to promote the occurrence of certain cancers, leading to adverse effects on patients' lives. Propofol, as an anesthetic, not only has positive effects on immunity, but also has an anticancer effect, making it significant in oncologic surgery.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Guangqiang You, Chen Zhou, Lei Wang, Zefeng Liu, He Fang, Xiaoxao Yao, Xuewen Zhang
Summary: The COMMD proteins are involved in various biological activities and have been linked to a wide range of disorders, including hepatitis, ischemia, HIV infection, and cancer. In particular, their role in tumors has been extensively studied, and they can either promote or inhibit different types of cancer. COMMD proteins have an impact on tumor progression, invasion, metastasis, and angiogenesis, and are associated with key signaling pathways and oncogenes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shuyan Zhang, Xinyue Zhang, Xuanzhong Wang, Chen Li, Chuan He, Tianfei Luo, Pengfei Ge
Summary: This study investigated the treatment effect of maltol on ischemia-induced neuron damage using an oxygen and glucose deprivation (OGD) model in SH-SY5Y cells. The results showed that maltol protected the cells against OGD-induced chromatinolysis by inhibiting two reactive oxygen species (ROS)-regulated pathways and maintaining the levels of xCT and catalase.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Microbiology
Lei Wang, Zhihao Xie, Guoliang Li, Guangyao Li, Jianmin Liang
Summary: This study used Mendelian randomization to investigate the causal relationship between gut microbiota and ADHD. The results suggest a potential causal link between certain gut bacteria and the risk of developing ADHD, as well as the protective effects of other gut bacteria. This research provides a foundation for understanding the causal relationship between gut microbiota and ADHD.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
