The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies

Momelotinib sensitizes glioblastoma cells to temozolomide by enhancement of autophagy via JAK2/STAT3 inhibition

(2019) Tie Liu et al.   ONCOLOGY REPORTS

Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis

(2019) Riccardo Bazzoni et al.   Cancers

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells

(2019) Nishani Rajakulendran et al.   GENES & DEVELOPMENT

Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α

(2019) Jose L. Nieto-González et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity

(2018) Cong Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway

(2018) Hong Li et al.   Journal of Hematology & Oncology

Overexpression of mTOR and p(240–244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival

(2018) Luis Eduardo Machado et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

(2018) Xihang Chen et al.   Stem Cells International

Targeting autophagy for combating chemoresistance and radioresistance in glioblastoma

(2018) Matthew A. Taylor et al.   APOPTOSIS

Hedgehog Signaling Pathway and Autophagy in Cancer

(2018) Xian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ambiguous Effects of Autophagy Activation Following Hypoperfusion/Ischemia

(2018) Michela Ferrucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of sonic hedgehog and PI3K/Akt/mTOR pathways cooperate in suppressing survival, self-renewal and tumorigenic potential of glioblastoma-initiating cells

(2018) Rajesh Nanta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

SOX3 can promote the malignant behavior of glioblastoma cells

(2018) Jelena Marjanovic Vicentic et al.   CELLULAR ONCOLOGY

Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells

(2018) Barbara Colella et al.   CELLULAR SIGNALLING

Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence

(2018) Carmen Mecca et al.   DISEASE MARKERS

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

(2018) Francesco Marampon et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

On the Role of Basal Autophagy in Adult Neural Stem Cells and Neurogenesis

(2018) Lucía Casares-Crespo et al.   Frontiers in Cellular Neuroscience

Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation

(2018) Zhennan Tao et al.   Cell Death & Disease

TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells

(2017) Alessandro Magini et al.   HUMAN MOLECULAR GENETICS

Bioinformatic analyses reveal a distinct Notch activation induced by STAT3 phosphorylation in the mesenchymal subtype of glioblastoma

(2017) Wen Cheng et al.   JOURNAL OF NEUROSURGERY

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

(2017) Hua-fu Zhao et al.   Molecular Cancer

CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma

(2017) Ming Tu et al.   Molecular Medicine Reports

Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells

(2017) Goparaju Chandrika et al.   TUMOR BIOLOGY

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

(2017) Joachim Bischof et al.   TUMOR BIOLOGY

mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation

(2017) Samarpan Maiti et al.   Cell Death & Disease

Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

(2017) Michela Ferrucci et al.   Oncotarget

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma

(2017) Patricia C. Sanchez-Diaz et al.   PLoS One

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis

(2016) Pierre-Michaël Coly et al.   Autophagy

High mobility group box 1 induces the activation of the Janus kinase 2 and signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and rapamycin inhibit their activation

(2016) Guoliang Wang et al.   Bosnian Journal of Basic Medical Sciences

Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres

(2016) Manabu Natsumeda et al.   BRAIN PATHOLOGY

Cell of origin of glioma: biological and clinical implications

(2016) Sheila R Alcantara Llaguno et al.   BRITISH JOURNAL OF CANCER

mTOR inhibitor temsirolimus and MEK1/2 inhibitor U0126 promote chromosomal instability and cell type-dependent phenotype changes of glioblastoma cells

(2016) A.A. Stepanenko et al.   GENE

Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance

(2016) Ahmed M. Hegazy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin-Loaded Layered Double Hydroxide Nanoparticles-Induced Autophagy for Reducing Glioma Cell Migration and Invasion

(2016) Haixia Zhang et al.   Journal of Biomedical Nanotechnology

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex

(2016) Andrew R. Tee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’

(2016) Soha Jawhari et al.   Cell Death & Disease

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions

(2016) Paola Lenzi et al.   Frontiers in Neuroanatomy

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

(2016) Xiaoman Li et al.   Oncotarget

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

(2016) Yu-Chen Cheng et al.   Oncotarget

Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

(2016) Song Xue et al.   Oncotarget

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling

(2016) Goparaju Chandrika et al.   Scientific Reports

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma

(2016) Laura Garros-Regulez et al.   Frontiers in Oncology

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells

(2016) Iwona Anna Ciechomska et al.   Scientific Reports

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner

(2015) Massimo Nabissi et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

(2015) Myriam Catalano et al.   Molecular Oncology

Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development

(2015) Hui Zong et al.   Cold Spring Harbor Perspectives in Biology

Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-κB Signaling Pathway

(2015) Yuming Jiao et al.   Nutrients

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Roles of mTOR Signaling in Brain Development

(2015) Da Yong Lee   Experimental Neurobiology

High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2014) R. Stupp et al.   ANNALS OF ONCOLOGY

Itraconazole suppresses the growth of glioblastoma through induction of autophagy

(2014) Rui Liu et al.   Autophagy

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells

(2014) Jonathan Pratt et al.   CELLULAR SIGNALLING

mTOR regulates brain morphogenesis by mediating GSK3 signaling

(2014) M. Ka et al.   DEVELOPMENT

The mTOR signaling pathway as a treatment target for intracranial neoplasms

(2014) D. Pachow et al.   NEURO-ONCOLOGY

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

(2014) Encouse B. Golden et al.   Neurosurgical Focus

Ubiquitin Carboxyl Terminal Hydrolyase L1 -Suppressed Autophagic Degradation of p21WAF1/Cip1 as a Novel Feedback Mechanism in the Control of Cardiac Fibroblast Proliferation

(2014) Xiaoming Zhang et al.   PLoS One

Isolation of Cancer Stem Cells from Three Human Glioblastoma Cell Lines: Characterization of Two Selected Clones

(2014) Fortunata Iacopino et al.   PLoS One

Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases

(2014) Hidetoshi Kassai et al.   Cell Reports

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature

(2014) Maria-del-Mar Inda et al.   Cancers

NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

(2013) Wen-juan Wang et al.   ACTA PHARMACOLOGICA SINICA

microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells

(2013) Sergio Comincini et al.   CANCER BIOLOGY & THERAPY

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Efficacy of rapamycin against glioblastoma cancer stem cells

(2013) M. Mendiburu-Eliçabe et al.   Clinical & Translational Oncology

Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis

(2013) D. Cloetta et al.   JOURNAL OF NEUROSCIENCE

Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons

(2013) C. A. Lafourcade et al.   JOURNAL OF NEUROSCIENCE

Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

(2013) Sajjad Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

FIP200 is required for maintenance and differentiation of postnatal neural stem cells

(2013) Chenran Wang et al.   NATURE NEUROSCIENCE

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

(2013) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Targeting cancer stem cells in glioblastoma multiforme using mTOR inhibitors and the differentiating agent all-trans retinoic acid

(2013) MARISSA D. FRIEDMAN et al.   ONCOLOGY REPORTS

Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells

(2013) Atsushi Sato et al.   Stem Cell Research

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

(2013) Nathaniel W. Hartman et al.   Cell Reports

Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

(2012) Sameer Agnihotri et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Rapamycin inhibits the growth of glioblastoma

(2012) Antonietta Arcella et al.   BRAIN RESEARCH

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

FoxM1 and Wnt/ -Catenin Signaling in Glioma Stem Cells

(2012) A. Gong et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Phosphorylated 4E-binding protein 1 (p-4E-BP1): a novel prognostic marker in human astrocytomas

(2012) Penelope Korkolopoulou et al.   HISTOPATHOLOGY

UCHL1 acts as a colorectal cancer oncogene via activation of the β-catenin/TCF pathway through its deubiquitinating activity

(2012) JIALING ZHONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resistance to Hypoxia-Induced, BNIP3-Mediated Cell Death Contributes to an Increase in a CD133-Positive Cell Population in Human Glioblastomas In Vitro

(2012) Ulf Dietrich Kahlert et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mammalian Target of Rapamycin Signaling Is a Key Regulator of the Transit-Amplifying Progenitor Pool in the Adult and Aging Forebrain

(2012) G. N. Paliouras et al.   JOURNAL OF NEUROSCIENCE

The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

(2012) Tingxiu Xiang et al.   PLoS One

Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice

(2012) Tariq Bashir et al.   PLoS One

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

(2011) Lin Cheng et al.   EMBO JOURNAL

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells

(2011) Eduardo C. Filippi-Chiela et al.   PLoS One

Autophagy in Stem Cell Maintenance and Differentiation

(2011) Alexandre Teixeira Vessoni et al.   STEM CELLS AND DEVELOPMENT

Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy

(2010) Wenzhuo Zhuang et al.   BRAIN RESEARCH

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

(2010) Xin Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas

(2010) Xue-yuan Li et al.   JOURNAL OF NEURO-ONCOLOGY

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

(2010) S Hussain et al.   LEUKEMIA

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

(2010) Jun Sunayama et al.   NEURO-ONCOLOGY

mTOR signaling in glioblastoma: lessons learned from bench to bedside

(2010) D. Akhavan et al.   NEURO-ONCOLOGY

Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR

(2010) Atsushi Sato et al.   NEUROSCIENCE LETTERS

Cholesterol trafficking is required for mTOR activation in endothelial cells

(2010) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of autophagy in sensitizing malignant glioma cells to radiation therapy

(2009) W. Zhuang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties

(2009) Aurélie Tchoghandjian et al.   BRAIN PATHOLOGY

Autophagy impairment inhibits differentiation of glioma stem/progenitor cells

(2009) Yaodong Zhao et al.   BRAIN RESEARCH

Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma

(2009) R. J. Ward et al.   CANCER RESEARCH

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

(2009) Qinghai Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Mammalian Target of Rapamycin Signaling Pathway Contributes to Glioma Progression and Patients' Prognosis

(2009) Jinfu Yang et al.   JOURNAL OF SURGICAL RESEARCH

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

(2009) Xing Fan et al.   STEM CELLS

Stem cells of the adult mammalian brain and their niche

(2008) O. Basak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signal transduction molecules in gliomas of all grades

(2008) Ralph P. Ermoian et al.   JOURNAL OF NEURO-ONCOLOGY

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

(2008) Jialiang Wang et al.   PLoS One

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER