Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

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Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein

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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

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Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

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Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

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Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein

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Inducing Indigestion: Companies Embrace Autophagy Inhibitors

(2011) K. Garber   JNCI-Journal of the National Cancer Institute

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

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Arsenic trioxide — An old drug rediscovered

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Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

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Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide

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The regulation of autophagy - unanswered questions

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Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

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Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis

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Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

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As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia

(2010) J.-H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis

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Biological Responses to Arsenic Compounds

(2009) Leonidas C. Platanias   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin B-mediated Autophagy Flux Facilitates the Anthrax Toxin Receptor 2-mediated Delivery of Anthrax Lethal Factor into the Cytoplasm

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Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

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Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR–ABL cleavage and elimination of chronic myelogenous leukemia cells

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Interferon-Dependent Engagement of Eukaryotic Initiation Factor 4B via S6 Kinase (S6K)- and Ribosomal Protein S6K-Mediated Signals

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A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

(2009) Q.-Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

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Arsenic trioxide

(2008) Mark R Litzow   EXPERT OPINION ON PHARMACOTHERAPY

Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

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PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Cysteine cathepsin proteases as pharmacological targets in cancer

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