Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Expression of Hypoxia-Inducible Factor (HIF)-1αand Vascular Endothelial Growth Factor (VEGF)-D As Outcome Predictors in Resected Esophageal Squamous Cell Carcinoma

(2013) Ching Tzao et al.   DISEASE MARKERS

Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis

(2009) S Rasheed et al.   BRITISH JOURNAL OF CANCER

Heterozygosity for Hypoxia Inducible Factor 1  Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model

(2009) J. A. Bertout et al.   CANCER RESEARCH

Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma

(2009) Klaus Jürgen Schmitz et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer

(2009) Simona Nanni et al.   JOURNAL OF CLINICAL INVESTIGATION

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

(2009) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Targeted Systemic Delivery of a Therapeutic siRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice

(2009) Xu-Li Wang et al.   MOLECULAR PHARMACEUTICS

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses

(2009) Mitsuhiro Nakamura et al.   VIROLOGY

Comment on the role of FIH in the inhibitory effect of bortezomib on hypoxia-inducible factor-1

(2008) S. Kaluz et al.   BLOOD

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1

(2008) D. H. Shin et al.   BLOOD

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study

(2008) Alexandros Daponte et al.   BMC CANCER

Kaposi's Sarcoma-Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1  to Induce Vascular Endothelial Growth Factor Expression

(2008) Y. C. Shin et al.   CANCER RESEARCH

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

HIF-1α and HIF-2α have divergent roles in colon cancer

(2008) Takaaki Imamura et al.   INTERNATIONAL JOURNAL OF CANCER

The role of hypoxia in recurrence following resection of Dukes’ B colorectal cancer

(2008) R. Rajaganeshan et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Overexpression of Intrinsic Hypoxia Markers HIF1α and CA-IX Predict for Local Recurrence in Stage T1-T2 Glottic Laryngeal Carcinoma Treated With Radiotherapy

(2008) M.L. Schrijvers et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Targeting Hypoxia-inducible Factor-1α With Tf–PEI–shRNA Complex via Transferrin Receptor–mediated Endocytosis Inhibits Melanoma Growth

(2008) Yeqiang Liu et al.   MOLECULAR THERAPY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY