Interplay Between Autophagy and Wnt/β-Catenin Signaling in Cancer: Therapeutic Potential Through Drug Repositioning

Exploring Dysregulated Signaling Pathways in Cancer.

(2020) Sabah Nisar et al.   CURRENT PHARMACEUTICAL DESIGN

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

(2019) Jiangbo Wang et al.   BIOCHEMICAL JOURNAL

Sorafenib/MEK inhibitor combination inhibits tumor growth and the Wnt/β‑catenin pathway in xenograft models of hepatocellular carcinoma

(2019) Hung Huynh et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

(2019) Jerry Harb et al.   Current Oncology Reports

Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells

(2019) Cheng-Wei Chu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

(2019) Apirat Chaikuad et al.   BIOCHEMICAL JOURNAL

Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway

(2019) Satabdi Datta et al.   APOPTOSIS

Towards the first targeted therapy for triple-negative breast cancer: Repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor

(2019) Kamal Ahmed et al.   CANCER LETTERS

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

(2019) Qiancheng Jing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities

(2019) Eduardo José Barbosa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

The Controversial Role of Autophagy in Tumor Development: A Systematic Review

(2019) Bridilla Luiza Colhado Rodrigues et al.   IMMUNOLOGICAL INVESTIGATIONS

Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

(2019) Alan Talevi et al.   Expert Opinion on Drug Discovery

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Wnt inhibitory factor-1-mediated autophagy inhibits Wnt/β-catenin signaling by downregulating dishevelled-2 expression in non-small cell lung cancer cells

(2018) Xinmei Luo et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

(2018) Qing Fan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Abrus agglutinin stimulates BMP-2-dependent differentiation through autophagic degradation of β-catenin in colon cancer stem cells

(2018) Prashanta K. Panda et al.   MOLECULAR CARCINOGENESIS

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

(2018) Matheus Dyczynski et al.   CANCER LETTERS

Review of Drug Repositioning Approaches and Resources

(2018) Hanqing Xue et al.   International Journal of Biological Sciences

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

(2018) Alex J Eustace et al.   BMC CANCER

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy in Cancer: Regulation by Small Molecules

(2018) Allison S. Limpert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Autophagy: The spotlight for cellular stress responses

(2017) Palaniyandi Ravanan et al.   LIFE SCIENCES

Wnt/β-catenin signaling pathway activation reverses gemcitabine resistance by attenuating Beclin1-mediated autophagy in the MG63 human osteosarcoma cell line

(2017) Hao Tao et al.   Molecular Medicine Reports

DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy

(2017) Ruo-nan Li et al.   Scientific Reports

The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma

(2017) Ming Yao et al.   Journal of Cancer

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

CLDN1 Increases Drug Resistance of Non-Small Cell Lung Cancer by Activating Autophagy via Up-Regulation of ULK1 Phosphorylation

(2017) Zhenhuan Zhao et al.   MEDICAL SCIENCE MONITOR

Wnt signaling in triple-negative breast cancer

(2017) SÖ-G Pohl et al.   Oncogenesis

Autophagy in Cancer Therapy

(2017) Simone Fulda   Frontiers in Oncology

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia

(2016) Abdul Salam Khan et al.   TUMOR BIOLOGY

Role of Wnt/β-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells

(2016) Nan Su et al.   Oncology Letters

Regulation of Autophagy of Prostate Cancer Cells by β-Catenin Signaling

(2015) Rongkai Lin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intervening in β-Catenin Signaling by Sulindac Inhibits S100A4-Dependent Colon Cancer Metastasis

(2015) Ulrike Stein et al.   NEOPLASIA

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity

(2014) Michelle Cicchini et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Diabetes, pancreatic cancer, and metformin therapy

(2014) Jun Gong et al.   Frontiers in Physiology

Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines

(2013) Guangxu Jin et al.   DRUG DISCOVERY TODAY

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

The LC3 interactome at a glance

(2013) P. Wild et al.   JOURNAL OF CELL SCIENCE

Celecoxib Inhibits β-Catenin-Dependent Survival of the Human Osteosarcoma MG-63 Cell Line

(2013) J-J Xia et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Nonsteroidal Anti-inflammatory Drugs Diclofenac and Celecoxib Attenuates Wnt/β-Catenin/Tcf Signaling Pathway in Human Glioblastoma Cells

(2013) Gangadhara Reddy Sareddy et al.   NEUROCHEMICAL RESEARCH

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/ -Catenin-Mediated Transcription in Human Breast Tumor Cells

(2011) H. N. Tinsley et al.   Cancer Prevention Research

Genetic architecture of cancer and other complex diseases: lessons learned and future directions

(2011) Lucia A. Hindorff et al.   CARCINOGENESIS

β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome–aggresome–autophagosome–lysosome pathway

(2011) K Sukhdeo et al.   LEUKEMIA

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

(2011) Wenyan Lu et al.   PLoS One

From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer

(2010) Sarah S Knox   Cancer Cell International

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

(2009) Ho-Jin Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells

(2009) Jie Li et al.   ANNALS OF SURGICAL ONCOLOGY

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

(2009) Alejandro Vazquez-Martin et al.   PLoS One

Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation

(2008) Wenyan Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability

(2008) Mi Ran Kang et al.   JOURNAL OF PATHOLOGY