Role of tumor and host autophagy in cancer metabolism

Blockade of RAF and autophagy is the one-two punch to take out Ras

(2019) Eileen White   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

(2019) Chih-Shia Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

(2019) Vrushank Bhatt et al.   GENES & DEVELOPMENT

Host Control of Tumor Feeding: Autophagy Holds the Key

(2019) Anthony Venida et al.   Cell Metabolism

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

(2018) Carmela De Santo et al.   Journal of Hematology & Oncology

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

(2018) Seong M. Kim et al.   Cancer Discovery

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

(2018) Joo Sang Lee et al.   CELL

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

(2018) Justyna Magdalena Przystal et al.   Cell Death & Disease

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Safety, efficacy, and clinical utility of asparaginase in the treatment of adult patients with acute lymphoblastic leukemia

(2017) Jamie Koprivnikar et al.   OncoTargets and Therapy

A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor

(2017) Weitao Shen et al.   Cell Death & Disease

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

Arginine Metabolism Revisited

(2016) Sidney M Morris   JOURNAL OF NUTRITION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Tumor suppressor functions of BNIP3 and mitophagy

(2015) Aparajita H Chourasia et al.   Autophagy

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Arginine deprivation in cancer therapy

(2015) Lynn G. Feun et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

(2015) Oula Khoury et al.   JOURNAL OF NEURO-ONCOLOGY

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth

(2015) Jonathan Lévy et al.   NATURE CELL BIOLOGY

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

(2014) H Maes et al.   Cell Death & Disease

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia

(2012) K Morrow et al.   LEUKEMIA

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

(2011) Daniel J Klionsky et al.   Autophagy

Arginases and arginine deficiency syndromes

(2011) Sidney M. Morris   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer

(2010) Xinyu Wu et al.   BREAST CANCER RESEARCH AND TREATMENT

Arginine Deprivation, Autophagy, Apoptosis (AAA) for the Treatment of Melanoma

(2010) N. Savaraj et al.   CURRENT MOLECULAR MEDICINE

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

(2010) Barbara Delage et al.   INTERNATIONAL JOURNAL OF CANCER

Alternatively Activated Macrophage Possess Antitumor Cytotoxicity That Is Induced by IL-4 and Mediated by Arginase-1

(2010) Julia I. Ellyard et al.   JOURNAL OF IMMUNOTHERAPY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Parkin as a tumor suppressor gene for hepatocellular carcinoma

(2008) M Fujiwara et al.   ONCOGENE

Stimulation of Prostate Cancer Cellular Proliferation and Invasion by the Androgen Receptor Co-Activator ARA70β

(2007) Yi Peng et al.   AMERICAN JOURNAL OF PATHOLOGY