The role of YAP/TAZ activity in cancer metabolic reprogramming

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis

(2018) Ruochan Chen et al.   HEPATOLOGY

The Hippo pathway in normal development and cancer

(2018) Marcello Maugeri-Saccà et al.   PHARMACOLOGY & THERAPEUTICS

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

(2018) Amin Ardestani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism

(2018) Jaemin Lee et al.   Molecular Metabolism

FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma

(2017) Lijuan Song et al.   EXPERIMENTAL CELL RESEARCH

Biomechanical strain-induced modulation of proliferation coincides with an ERK1/2-independent nuclear YAP localization

(2017) Diana Hülter-Hassler et al.   EXPERIMENTAL CELL RESEARCH

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

(2017) Keane K.Y. Lai et al.   GASTROENTEROLOGY

YAP suppresses gluconeogenic gene expression through PGC1α

(2017) Yue Hu et al.   HEPATOLOGY

Verteporfin Inhibits Cell Proliferation and Induces Apoptosis in Human Leukemia NB4 Cells without Light Activation

(2017) Min Chen et al.   International Journal of Medical Sciences

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

(2017) Changmin Peng et al.   MOLECULAR CELL

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

(2017) A Noto et al.   ONCOGENE

The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer

(2017) Fabio Ciccarone et al.   SEMINARS IN CANCER BIOLOGY

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

(2017) Xiao Zhang et al.   Nature Communications

GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

(2017) Lingdi Wang et al.   Nature Communications

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

(2017) Y Gao et al.   Oncogenesis

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring

(2016) Ling Wu et al.   Cell Metabolism

Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression

(2016) Wang Pan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

The Primary Effect on the Proteome ofARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level

(2016) Aaron R. Goldman et al.   MOLECULAR & CELLULAR PROTEOMICS

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

(2016) PuiYee Chan et al.   Nature Chemical Biology

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration

(2016) Zhe Liu et al.   Cell Reports

Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis

(2016) Sijia Huang et al.   Genome Medicine

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

(2016) Yaoting Deng et al.   Protein & Cell

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

(2016) Marie-Julie Nokin et al.   eLife

Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts

(2015) C Angelucci et al.   BRITISH JOURNAL OF CANCER

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

(2015) Guang-Ming Huang et al.   CANCER LETTERS

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model

(2015) Wenjuan Li et al.   MOLECULAR CARCINOGENESIS

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

Impaired Hippo signaling promotes Rho1–JNK-dependent growth

(2015) Xianjue Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)

(2014) Sudhir Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP activation is an early event and a potential therapeutic target in liver cancer development

(2014) Andrea Perra et al.   JOURNAL OF HEPATOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

(2014) Behzad Yeganeh et al.   PHARMACOLOGY & THERAPEUTICS

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

(2013) Menno J. Oudhoff et al.   DEVELOPMENTAL CELL

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

YAP oncogene overexpression supercharges colon cancer proliferation

(2012) Joseph Avruch et al.   CELL CYCLE

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway

(2010) C. J. Huntoon et al.   CANCER RESEARCH

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

(2009) Derek M. Erion et al.   Cell Metabolism

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY