Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer’s Disease and Stroke

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

(2021) J. A. F. Demandt et al.   Scientific Reports

Impact of Tau on Neurovascular Pathology in Alzheimer's Disease

(2021) Elisa Canepa et al.   Frontiers in Neurology

Physiological and Pathological Ageing of Astrocytes in the Human Brain

(2021) Marloes Verkerke et al.   NEUROCHEMICAL RESEARCH

Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease

(2021) Hattapark Dejakaisaya et al.   EPILEPSIA

Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents

(2021) Irene Bulli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microvascular Degeneration Occurs Before Plaque Onset and Progresses with Age in 3xTg AD Mice

(2021) Dominic D. Quintana et al.   NEUROBIOLOGY OF AGING

Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke

(2021) Jara Cárcel-Márquez et al.   STROKE

Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy

(2021) Joseph O. Ojo et al.   Frontiers in Aging Neuroscience

Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

(2021) Michel J. A. M. van Putten et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease

(2021) Cameron S. McAlpine et al.   NATURE

Collateral augmentation treatment with a combination of acetazolamide and head-down tilt in a rat ischemic stroke model

(2020) Minho Han et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Alzheimer’s Disease and Vascular Aging

(2020) Marta Cortes-Canteli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Modulators of microglia activation and polarization in ischemic stroke (Review)

(2020) Cheng‑Ting Jiang et al.   Molecular Medicine Reports

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

(2020) Krystal Sotolongo et al.   Alzheimers Research & Therapy

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

(2020) Paul C. McDonald et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

(2020) Emily F. Willis et al.   CELL

Methazolamide in high-altitude illnesses

(2020) Hui Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke

(2020) Sajad Sarvari et al.   METABOLIC BRAIN DISEASE

Basement Membrane Changes in Ischemic Stroke

(2020) Minkyung Kang et al.   STROKE

The Brain’s Glymphatic System: Current Controversies

(2020) Humberto Mestre et al.   TRENDS IN NEUROSCIENCES

Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival

(2020) Lidija Radenovic et al.   Aging-US

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

(2020) Chandra B. Mishra et al.   MEDICINAL RESEARCH REVIEWS

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

The role of carbonic anhydrases in extinction of contextual fear memory

(2020) Scheila Daiane Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Remodeling of the Brain Vasculature Following Stroke

(2020) Moises Freitas-Andrade et al.   Frontiers in Physiology

The Expression of Carbonic Anhydrases II, IX and XII in Brain Tumors

(2020) Joonas Haapasalo et al.   Cancers

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

(2020) Berislav V. Zlokovic et al.   Alzheimers & Dementia

Antibacterial carbonic anhydrase inhibitors: an update on the recent literature

(2020) Claudiu T. Supuran et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

(2020) Diji Kuriakose et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions

(2020) Bor-Ren Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone

(2020) Jacob T. Andring et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

(2020) Andrea Angeli et al.   Metabolites

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment

(2019) Patrick Oeckl et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

(2019) Jean C. Cruz Hernández et al.   NATURE NEUROSCIENCE

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

(2019) Alex J. Smith et al.   Acta Neuropathologica Communications

Preventing dementia by preventing stroke: The Berlin Manifesto

(2019) Vladimir Hachinski et al.   Alzheimers & Dementia

Matrix metalloproteinases and ADAMs in stroke

(2019) Joan Montaner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Carbonic anhydrases as disease markers

(2019) Sabina Zamanova et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

(2019) Rebecca Parodi-Rullán et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke

(2019) Pascal Gervois et al.   Frontiers in Immunology

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer’s Disease

(2019) Gustavo Provensi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

(2019) Heather L. McConnell et al.   NEUROCHEMISTRY INTERNATIONAL

Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery

(2019) Wael Eldahshan et al.   PHARMACOLOGICAL RESEARCH

Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

(2019) Meng‐yan Hu et al.   CNS Neuroscience & Therapeutics

Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity

(2018) María E. Solesio et al.   AGING CELL

Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice

(2018) Rajesh K.K. Sanku et al.   BEHAVIOURAL PHARMACOLOGY

The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

(2018) Erin L. Boespflug et al.   BIOLOGICAL PSYCHIATRY

Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options

(2018) Emine Sekerdag et al.   Current Neuropharmacology

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Amyloidosis Associated with Cerebral Amyloid Angiopathy: Cell Signaling Pathways Elicited in Cerebral Endothelial Cells

(2018) Jorge Ghiso et al.   JOURNAL OF ALZHEIMERS DISEASE

Basement membrane and stroke

(2018) Yao Yao   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Stroke and dementia risk: A systematic review and meta-analysis

(2018) Elżbieta Kuźma et al.   Alzheimers & Dementia

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Carbonic anhydrase XII functions in health and disease

(2017) Abdul Waheed et al.   GENE

Carbonic anhydrase inhibitors modify intracellular pH transients and contractions of rat middle cerebral arteries during CO2/HCO3– fluctuations

(2017) Jacob K Rasmussen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII

(2017) Andrea Angeli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain

(2017) Clare Howarth et al.   JOURNAL OF NEUROSCIENCE

Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2017) Jeff Sevigny et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

(2017) Lucas Canto de Souza et al.   NEUROPHARMACOLOGY

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

(2017) Maoxue Tang et al.   Nature Communications

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies

(2017) Diana L Castillo-Carranza et al.   Aging and Disease

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration

(2016) Amelia Pollard et al.   Aging-US

Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats

(2016) Lorena A. Vargas et al.   CARDIOVASCULAR PATHOLOGY

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Activation of classical estrogen receptor subtypes reduces tight junction disruption of brain endothelial cells under ischemia/reperfusion injury

(2016) Jin A. Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas

(2016) Suleyman Akocak et al.   JOURNAL OF MEDICINAL CHEMISTRY

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain

(2016) Silvia Fossati et al.   NEUROBIOLOGY OF DISEASE

Long-Term Risk of Dementia Among Survivors of Ischemic or Hemorrhagic Stroke

(2016) Priscila Corraini et al.   STROKE

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice

(2016) Mingchang Li et al.   Scientific Reports

Neuronal and Vascular Interactions

(2015) Benjamin J. Andreone et al.   Annual Review of Neuroscience

Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit

(2015) Islam N. Mohamed et al.   ANTIOXIDANTS & REDOX SIGNALING

Matrix metalloproteinases as therapeutic targets for stroke

(2015) Yi Yang et al.   BRAIN RESEARCH

Carbonic anhydrase IX inhibitors in cancer therapy: an update

(2015) Claudiu T Supuran et al.   Future Medicinal Chemistry

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3−secretion revealed by disease causing human mutation

(2015) Jeong Hee Hong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Topiramate protects against glutamate excitotoxicity via activating BDNF/TrkB-dependent ERK pathway in rodent hippocampal neurons

(2015) Xiao-Yuan Mao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

(2015) Jaromir Pastorek et al.   SEMINARS IN CANCER BIOLOGY

Investigating Human Neurovascular Coupling Using Functional Neuroimaging: A Critical Review of Dynamic Models

(2015) Clément Huneau et al.   Frontiers in Neuroscience

Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain

(2015) Ryan J. Day et al.   PLoS One

Cardiovascular risk factors and future risk of Alzheimer’s disease

(2014) Renée FAG de Bruijn et al.   BMC Medicine

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

(2014) Bogdan Draghici et al.   CHEMICAL COMMUNICATIONS

Targeting the Neurovascular Unit in Brain Trauma

(2014) Josephine Lok et al.   CNS Neuroscience & Therapeutics

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

(2013) Eva Ruusuvuori et al.   EMBO JOURNAL

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

(2013) Sabrina Engelhardt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

(2013) Susan A. Austin et al.   JOURNAL OF NEUROCHEMISTRY

Reactive Oxygen Species-Caspase-3 Relationship in Mediating Blood-Brain Barrier Endothelial Cell Hyperpermeability Following Oxygen-Glucose Deprivation and Reoxygenation

(2013) Himakarnika Alluri et al.   MICROCIRCULATION

Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism

(2013) G. N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Updated Definition of Stroke for the 21st Century

(2013) Ralph L. Sacco et al.   STROKE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Structure, function and applications of carbonic anhydrase isozymes

(2012) Md. Imtaiyaz Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure

(2012) Chengeng Liu et al.   Clinical & Developmental Immunology

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2012) Claudiu T Supuran   EXPERT OPINION ON EMERGING DRUGS

Acetazolamide for the Prevention of Acute Mountain Sickness—A Systematic Review and Meta‐analysis

(2012) Neil D. Ritchie et al.   JOURNAL OF TRAVEL MEDICINE

Injury and repair in the neurovascular unit

(2012) Changhong Xing et al.   NEUROLOGICAL RESEARCH

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer’s Aβ

(2012) S Fossati et al.   Cell Death & Disease

Carbonic anhydrase II autoantibody and oxidative stress in rheumatoid arthritis

(2011) Ahmet Alver et al.   CLINICAL BIOCHEMISTRY

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Insights into Caspase-Mediated Apoptotic Pathways Induced by Amyloid-ß in Cerebral Microvascular Endothelial Cells

(2011) Silvia Fossati et al.   Neurodegenerative Diseases

Brain phenotype of carbonic anhydrase IX-deficient mice

(2011) Pei-wen Pan et al.   TRANSGENIC RESEARCH

Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage

(2011) Fuyou Guo et al.   Translational Stroke Research

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

(2010) Costantino Iadecola   ACTA NEUROPATHOLOGICA

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

(2010) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls

(2009) S. Fossati et al.   FASEB JOURNAL

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Estrogen-Receptor-Mediated Protection of Cerebral Endothelial Cell Viability and Mitochondrial Function after Ischemic Insult in vitro

(2009) Jiabin Guo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Topiramate attenuates hippocampal injury after experimental subarachnoid hemorrhage in rabbits

(2009) Hakan Seçkin et al.   NEUROLOGICAL RESEARCH

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury

(2009) Xin Wang et al.   STROKE

Epidemiological Studies of the Effect of Stroke on Incident Dementia

(2009) George M. Savva et al.   STROKE

Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

(2008) Vijay M. Krishnamurthy et al.   CHEMICAL REVIEWS

Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

(2008) Mika Hilvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Cytochrome c Release with Therapeutic Potential for Huntington's Disease

(2008) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Therapeutic applications of glycosidic carbonic anhydrase inhibitors

(2008) Jean-Yves Winum et al.   MEDICINAL RESEARCH REVIEWS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Evaluating middle cerebral artery collateral blood flow reserve using acetazolamide transcranial Doppler ultrasound in patients with carotid occlusive disease

(2008) Stephen M. Russell et al.   SURGICAL NEUROLOGY