Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
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Title
Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
Authors
Keywords
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Journal
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-07-21
DOI
10.1002/med.21713
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- New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides
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- Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors
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- Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures
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- Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII
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- Application of Monoclonal Antibody G250 Recognizing Carbonic Anhydrase IX in Renal Cell Carcinoma
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- Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture
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- Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo
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- Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates
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- Breathing and sleep at high altitude
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- Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
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- Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
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- Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
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- Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs
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- Ocular perfusion pressure and ocular blood flow in glaucoma
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- Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)
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- Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogenHelycobacter pyloriwith anions
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- Tricyclic Sulfonamides Incorporating Benzothiopyrano[4,3-c]pyrazole and Pyridothiopyrano[4,3-c]pyrazole Effectively Inhibit α- and β-Carbonic Anhydrase: X-ray Crystallography and Solution Investigations on 15 Isoforms
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- Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts
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- Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII
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- Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo
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- Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
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- Characterization of Carbonic Anhydrase IX Interactome Reveals Proteins Assisting Its Nuclear Localization in Hypoxic Cells
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- Multimodal Imaging and Detection Strategy With 124 I-Labeled Chimeric Monoclonal Antibody cG250 for Accurate Localization and Confirmation of Extent of Disease During Laparoscopic and Open Surgical Resection of Clear Cell Renal Cell Carcinoma
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- Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies
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- Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition
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- In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds
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- Medical Management of Parkinsons Disease: Focus on Neuroprotection
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- Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors
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- Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors
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- Design, Synthesis, and Biological Evaluation of Novel Carbohydrate-Based Sulfamates as Carbonic Anhydrase Inhibitors
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- Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
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- Using Recombinant Tissue Plasminogen Activator to Treat Acute Ischemic Stroke in China
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- Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage
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- Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955-2007
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- Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity
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- NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II
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- 7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
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- Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
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- Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis
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- Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII
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- Carbonic Anhydrase Related Protein VIII and its Role in Neurodegeneration and Cancer
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- Sulfonamide Linked Neoglycoconjugates−A New Class of Inhibitors for Cancer-Associated Carbonic Anhydrases
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- Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule
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- Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update
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- Protein Carbonylation in Skeletal Muscles: Impact on Function
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- Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates?
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- Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
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- Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
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- Pathogenesis of retinitis pigmentosa associated with apoptosis-inducing mutations in carbonic anhydrase IV
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- Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia
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- Diuretics: From Classical Carbonic Anhydrase Inhibitors to Novel Applications of the Sulfonamides
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- Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II
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- Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides
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- Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
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- Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide
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- Antibody therapy in renal cell carcinoma
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- Prevalence of chronic pain with neuropathic characteristics in the general population
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