Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review

(2021) Yi Yao et al.   Frontiers in Aging Neuroscience

Molecular mechanisms of K + clearance and extracellular space shrinkage—Glia cells as the stars

(2020) Nanna MacAulay   GLIA

Interstitial ions: A key regulator of state-dependent neural activity?

(2020) Rune Rasmussen et al.   PROGRESS IN NEUROBIOLOGY

Quantitative Imaging of Changes in Astrocytic and Neuronal Adenosine Triphosphate Using Two Different Variants of ATeam

(2020) Rodrigo Lerchundi et al.   Frontiers in Cellular Neuroscience

Glial glutamate transporter GLT ‐1 determines susceptibility to spreading depression in the mouse cerebral cortex

(2020) Hidenori Aizawa et al.   GLIA

Clearance of activity‐evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform‐selective AQP4 inhibitor

(2020) Trine Lisberg Toft‐Bertelsen et al.   GLIA

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

(2020) Goodwell Nzou et al.   Scientific Reports

Endovascular Treatment After Stroke Due to Large Vessel Occlusion for Patients Presenting Very Late From Time Last Known Well

(2020) Beom Joon Kim et al.   JAMA Neurology

Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function

(2020) Lisa Felix et al.   Frontiers in Physiology

Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

(2020) Shefeeq M. Theparambil et al.   Nature Communications

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

(2020) Dennis W. Choi   Frontiers in Neuroscience

Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery

(2020) Orsolya M. Tóth et al.   Biology-Basel

A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel

(2019) Kevin Strange et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ionic signalling in astroglia beyond calcium

(2019) Alexei Verkhratsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heterogeneity of activity-induced sodium transients between astrocytes of the mouse hippocampus and neocortex: Mechanisms and consequences

(2019) Daniel Ziemens et al.   JOURNAL OF NEUROSCIENCE

Kilquist syndrome: A novel syndromic hearing loss disorder caused by homozygous deletion of SLC12A2

(2019) Ellen F. Macnamara et al.   HUMAN MUTATION

Metabolic constraints of swelling‐activated glutamate release in astrocytes and their implication for ischemic tissue damage

(2019) Corinne S. Wilson et al.   JOURNAL OF NEUROCHEMISTRY

A Novel Na + -K + -Cl − Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke

(2019) Huachen Huang et al.   STROKE

Astrocyte–Neuron Interactions in the Striatum: Insights on Identity, Form, and Function

(2019) Baljit S. Khakh   TRENDS IN NEUROSCIENCES

Roles of glial ion transporters in brain diseases

(2019) Shanshan Song et al.   GLIA

Na+-dependent transporters: The backbone of astroglial homeostatic function

(2019) Alexei Verkhratsky et al.   CELL CALCIUM

On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals

(2019) Christine R. Rose et al.   CELL CALCIUM

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

(2019) Joachim W. Deitmer et al.   Frontiers in Neuroscience

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue

(2018) Jan Tønnesen et al.   CELL

Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons

(2018) Yixing Du et al.   EXPERIMENTAL NEUROLOGY

Astrocytic glycogen metabolism in the healthy and diseased brain

(2018) Lasse K. Bak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gliotransmission: Beyond Black-and-White

(2018) Iaroslav Savtchouk et al.   JOURNAL OF NEUROSCIENCE

Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

(2018) Todd A. Fiacco et al.   JOURNAL OF NEUROSCIENCE

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia

(2018) Schuichi Koizumi et al.   NEUROCHEMISTRY INTERNATIONAL

The signaling role for chloride in the bidirectional communication between neurons and astrocytes

(2018) Corinne S. Wilson et al.   NEUROSCIENCE LETTERS

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology

(2018) Meagan Milton et al.   Frontiers in Cellular Neuroscience

Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization

(2018) Ákos Menyhárt et al.   NEUROBIOLOGY OF DISEASE

Astrocyte-specific deletion of Kir6.1/K-ATP channel aggravates cerebral ischemia/reperfusion injury through endoplasmic reticulum stress in mice

(2018) Chong-Jin Zhong et al.   EXPERIMENTAL NEUROLOGY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms

(2017) Brian Roland Larsen et al.   GLIA

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

Differential Presynaptic ATP Supply for Basal and High-Demand Transmission

(2017) Courtney Sobieski et al.   JOURNAL OF NEUROSCIENCE

Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes

(2017) Niklas J. Gerkau et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Systemic administration of l -kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice

(2017) Dániel Péter Varga et al.   MICROVASCULAR RESEARCH

Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter

(2017) Behrouz Moshrefi-Ravasdjani et al.   NEUROCHEMICAL RESEARCH

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Astrocytic control of synaptic function

(2017) Thomas Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential

(2017) Joseph Glykys et al.   TRENDS IN NEUROSCIENCES

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization

(2017) Niklas Hübel et al.   PLoS Computational Biology

Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters

(2017) Mary Hongying Cheng et al.   eLife

The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

(2017) Michael V. Clausen et al.   Frontiers in Physiology

Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain

(2017) Ákos Menyhárt et al.   Scientific Reports

Functional anisotropic panglial networks in the lateral superior olive

(2016) Vanessa Augustin et al.   GLIA

Glial Na+-dependent ion transporters in pathophysiological conditions

(2016) Francesca Boscia et al.   GLIA

Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet

(2016) Julia Langer et al.   GLIA

Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation

(2016) Verena Untiet et al.   GLIA

Into rather unexplored terrain-transcellular transport across the blood-brain barrier

(2016) Marijke De Bock et al.   GLIA

Sodium signaling and astrocyte energy metabolism

(2016) Jean-Yves Chatton et al.   GLIA

Spreading depolarization triggered by elevated potassium is weak or absent in the rodent lower brain

(2016) R David Andrew et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model

(2016) Cordula Rakers et al.   JOURNAL OF CLINICAL INVESTIGATION

Large extracellular space leads to neuronal susceptibility to ischemic injury in a Na+/K + pumps–dependent manner

(2016) Niklas Hübel et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

A Biophysical Model for Cytotoxic Cell Swelling

(2016) Koen Dijkstra et al.   JOURNAL OF NEUROSCIENCE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Reactive astrocytes and therapeutic potential in focal ischemic stroke

(2016) Gourav Roy Choudhury et al.   NEUROBIOLOGY OF DISEASE

Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function

(2016) SoRi Jang et al.   NEURON

The Na+/HCO3− co-transporter is protective during ischemia in astrocytes

(2016) Hang Yao et al.   NEUROSCIENCE

Astrocytic mGluR5 and the tripartite synapse

(2016) A. Panatier et al.   NEUROSCIENCE

Astrocyte sodium signaling and neuro-metabolic coupling in the brain

(2016) C.R. Rose et al.   NEUROSCIENCE

Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR)

(2016) Stine F. Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Progression of Neuronal Damage in an In Vitro Model of the Ischemic Penumbra

(2016) Joost le Feber et al.   PLoS One

Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms

(2016) Brian Roland Larsen et al.   Frontiers in Physiology

Anions Govern Cell Volume: A Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization

(2016) Niklas Hübel et al.   PLoS One

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

(2015) Ravi L. Rungta et al.   CELL

Mechanisms of Anion Conduction by Coupled Glutamate Transporters

(2015) Jan-Philipp Machtens et al.   CELL

Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity

(2015) Claudia Karus et al.   GLIA

Loose excitation-secretion coupling in astrocytes

(2015) Nina Vardjan et al.   GLIA

Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs

(2015) Shotaro Michinaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ischemic Tolerance in Pre-Myelinated White Matter: The Role of Astrocyte Glycogen in Brain Pathology

(2015) Robert Fern   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell volume control in three dimensions: Water movement without solute movement

(2015) Frederick Sachs et al.   JOURNAL OF GENERAL PHYSIOLOGY

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes

(2015) Shefeeq M. Theparambil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Non-signalling energy use in the brain

(2015) Elisabeth Engl et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of the Astrocytic Na+, K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization

(2015) Leif Hertz et al.   NEUROCHEMICAL RESEARCH

A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

(2015) Olvert A. Berkhemer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular physiology of EAAT anion channels

(2015) Christoph Fahlke et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

K-Cl cotransporters, cell volume homeostasis, and neurological disease

(2015) Kristopher T. Kahle et al.   TRENDS IN MOLECULAR MEDICINE

The central role of aquaporins in the pathophysiology of ischemic stroke

(2015) Jasmine Vella   Frontiers in Cellular Neuroscience

Adapting brain metabolism to myelination and long-range signal transduction

(2014) Johannes Hirrlinger et al.   GLIA

White matter injury: Ischemic and nonischemic

(2014) Robert F. Fern et al.   GLIA

Glutamate synthesis has to be matched by its degradation - where do all the carbons go?

(2014) Ursula Sonnewald   JOURNAL OF NEUROCHEMISTRY

Novel determinants of the neuronal Cl−concentration

(2014) Eric Delpire et al.   JOURNAL OF PHYSIOLOGY-LONDON

Astrocytic glycogenolysis: mechanisms and functions

(2014) Leif Hertz et al.   METABOLIC BRAIN DISEASE

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte Ca2+ signalling: an unexpected complexity

(2014) Andrea Volterra et al.   NATURE REVIEWS NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

The Detrimental Role of Glial Acidification during Ischemia

(2014) Steven A. Sloan et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

A Novel Optical Intracellular Imaging Approach for Potassium Dynamics in Astrocytes

(2014) Theresa S. Rimmele et al.   PLoS One

Structure, function, and plasticity of GABA transporters

(2014) Annalisa Scimemi   Frontiers in Cellular Neuroscience

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Two sides of the same coin: Sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions

(2013) Christine R. Rose et al.   GLIA

Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia

(2013) Lucio Annunziato et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diffusing Substances during Spreading Depolarization: Analytical Expressions for Propagation Speed, Triggering, and Concentration Time Courses

(2013) B.-J. Zandt et al.   JOURNAL OF NEUROSCIENCE

Cl−homeodynamics in gap junction-coupled astrocytic networks on activation of GABAergic synapses

(2013) Kiyoshi Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel

(2013) M. B. Ulmschneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Electrodiffusive Model for Astrocytic and Neuronal Ion Concentration Dynamics

(2013) Geir Halnes et al.   PLoS Computational Biology

Water Permeability of Aquaporin-4 Channel Depends on Bilayer Composition, Thickness, and Elasticity

(2012) Jihong Tong et al.   BIOPHYSICAL JOURNAL

A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents

(2012) Natalie Winter et al.   BRAIN

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

(2012) Christian Steinhäuser et al.   GLIA

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin-4–dependent K+and water transport modeled in brain extracellular space following neuroexcitation

(2012) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Sodium dynamics: another key to astroglial excitability?

(2012) Sergei Kirischuk et al.   TRENDS IN NEUROSCIENCES

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ

(2011) Julia Langer et al.   GLIA

Heterogeneity in the penumbra

(2011) Gregory J del Zoppo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Counting Ion and Water Molecules in a Streaming File through the Open-Filter Structure of the K Channel

(2011) M. Iwamoto et al.   JOURNAL OF NEUROSCIENCE

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Ischemic Cerebral Damage

(2011) Jeannette Hofmeijer et al.   STROKE

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Ion changes and signalling in perisynaptic glia

(2009) Joachim W. Deitmer et al.   BRAIN RESEARCH REVIEWS

Water-Transporting Proteins

(2009) Thomas Zeuthen   JOURNAL OF MEMBRANE BIOLOGY

Functional significance of brain glycogen in sustaining glutamatergic neurotransmission

(2009) Helle M. Sickmann et al.   JOURNAL OF NEUROCHEMISTRY

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

(2009) C. K. Pfeffer et al.   JOURNAL OF NEUROSCIENCE

Synaptically induced sodium signals in hippocampal astrocytesin situ

(2009) Julia Langer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial

(2009) Jeannette Hofmeijer et al.   LANCET NEUROLOGY

Water transport between CNS compartments: functional and molecular interactions between aquaporins and ion channels

(2009) V. Benfenati et al.   NEUROSCIENCE

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Developmental profile and mechanisms of GABA-induced calcium signaling in hippocampal astrocytes

(2008) Silke D. Meier et al.   GLIA

Sodium signals in cerebellar Purkinje neurons and Bergmann glial cells evoked by glutamatergic synaptic transmission

(2008) Mustapha Bennay et al.   GLIA

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Chloride Accumulation Drives Volume Dynamics Underlying Cell Proliferation and Migration

(2008) Christa W. Habela et al.   JOURNAL OF NEUROPHYSIOLOGY

A Functional Role for Sodium-Dependent Glucose Transport across the Blood-Brain Barrier during Oxygen Glucose Deprivation

(2008) S. Vemula et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON