Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases

(2011) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases

(2011) Rohan A. Davis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II

(2011) H. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines

(2010) Anthony Bertucci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I–XIV with a series of natural product polyphenols and phenolic acids

(2010) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

(2010) Peter Burghout et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. The β-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides

(2010) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids

(2010) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

(2010) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Editorial [Hot Topic: Carbonic Anhydrases: Again, and Again, and Again (Executive Editor: Claudiu T. Supuran)]

(2010) Claudiu T. Supuran   CURRENT PHARMACEUTICAL DESIGN

Sulfonamide Linked Neoglycoconjugates−A New Class of Inhibitors for Cancer-Associated Carbonic Anhydrases

(2010) Marie Lopez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase fromBrucella suis

(2010) Pascale Joseph et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II

(2010) Katherine H. Sippel et al.   Journal of Physical Chemistry Letters

The Archetype γ-Class Carbonic Anhydrase (Cam) Contains Iron When Synthesized in Vivo†

(2009) Sheridan R. MacAuley et al.   BIOCHEMISTRY

The γ class of carbonic anhydrases

(2009) James G. Ferry   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases

(2009) John F. Domsic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Carbonic anhydrase inhibitors. The nematode α-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols

(2009) Murat Şentürk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal β-carbonic anhydrase from Candida albicans with sulfonamides

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

(2009) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode α-carbonic anhydrases

(2009) Letizia Crocetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with anions

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 β-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides

(2009) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active β-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

(2009) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic Anhydrase Inhibitors: Glycosylsulfanilamides Act as Subnanomolar Inhibitors of the Human Secreted Isoform VI

(2009) Jean-Yves Winum et al.   Chemical Biology & Drug Design

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

(2009) Peter Ebbesen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors. Comparison of Chlorthalidone and Indapamide X-ray Crystal Structures in Adducts with Isozyme II: When Three Water Molecules and the Keto−Enol Tautomerism Make the Difference†

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors. Cloning, Characterization, and Inhibition Studies of a New β-Carbonic Anhydrase fromMycobacterium tuberculosis

(2009) Isao Nishimori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Cloning, Characterization, and Inhibition Studies of the Rv1284 β-Carbonic Anhydrase fromMycobacterium tuberculosiswith Sulfonamides and a Sulfamate

(2009) Tomoko Minakuchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial β-Carbonic Anhydrases Rv1284 and Rv3273

(2009) Özlen Güzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

S-Glycosyl Primary Sulfonamides−A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases

(2009) Marie Lopez et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbonic anhydrases in fungi

(2009) S. Elleuche et al.   MICROBIOLOGY-SGM

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

(2009) Marina Asiedu et al.   PAIN

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study†

(2008) Albert A. Barrese et al.   BIOCHEMISTRY

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

(2008) Esra Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I–XIV

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I–XIV with a series of substituted phenols including paracetamol and salicylic acid

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates

(2008) Semra Isik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with anions

(2008) Semra Isik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV)

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide–isozyme II adduct

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors: Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

(2008) Vijay M. Krishnamurthy et al.   CHEMICAL REVIEWS

Diuretics: From Classical Carbonic Anhydrase Inhibitors to Novel Applications of the Sulfonamides

(2008) Claudiu Supuran   CURRENT PHARMACEUTICAL DESIGN

The α and β Classes Carbonic Anhydrases from Helicobacter pylori as Novel Drug Targets

(2008) Hiroaki Takeuchi et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic Anhydrase in the Scleractinian CoralStylophora pistillata

(2008) Aurélie Moya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides

(2008) Brendan L. Wilkinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cloning, Expression, Post-Translational Modifications and Inhibition Studies on the Latest Mammalian Carbonic Anhydrase Isoform, CA XV

(2008) Mika Hilvo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

(2008) Maamar Stiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic applications of glycosidic carbonic anhydrase inhibitors

(2008) Jean-Yves Winum et al.   MEDICINAL RESEARCH REVIEWS

External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans

(2008) Rebecca A. Hall et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

(2008) Yan Xu et al.   NATURE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited—old leads for new applications?

(2008) Claudia Temperini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY