Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases

(2011) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

Topiramate-induced weight loss: A review

(2011) Alberto Verrotti et al.   EPILEPSY RESEARCH

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

(2011) Kishore M Gadde et al.   LANCET

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP)

(2011) David B. Allison et al.   Obesity

Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials

(2011) C. K. Kramer et al.   Obesity Reviews

Pharmacologic Therapies for Obesity

(2010) Lee M. Kaplan   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I–topiramate complex

(2010) Vincenzo Alterio et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

(2009) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel pharmacotherapies for obesity poised to enter market

(2009) Dan Jones   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

(2008) Fatma-Zohra Smaine et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives

(2008) Sally-Ann Poulsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2008) Claudiu T Supuran et al.   EXPERT OPINION ON EMERGING DRUGS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY