Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage
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Title
Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage
Authors
Keywords
-
Journal
Alzheimers Research & Therapy
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-14
DOI
10.1186/s13195-019-0578-9
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Note: Only part of the references are listed.- NRF2 Activation in Cancer: From DNA to Protein
- (2019) Erica W. Cloer et al. CANCER RESEARCH
- Ginsenoside Re Inhibits ROS/ASK-1 Dependent Mitochondrial Apoptosis Pathway and Activation of Nrf2-Antioxidant Response in Beta-Amyloid-Challenged SH-SY5Y Cells
- (2019) Meichen Liu et al. MOLECULES
- Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition
- (2018) Erwin Cabrera et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
- (2018) Nora E. Gray et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Aβ-Exposed Hippocampal Neurons
- (2017) Nora E. Gray et al. Oxidative Medicine and Cellular Longevity
- Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice
- (2017) Natasa Dragicevic et al. JOURNAL OF ALZHEIMERS DISEASE
- Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
- (2016) Noemí Esteras et al. BIOLOGICAL CHEMISTRY
- Redox-based therapeutics in neurodegenerative disease
- (2016) G J McBean et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metabolic reprogramming during neuronal differentiation
- (2016) M Agostini et al. CELL DEATH AND DIFFERENTIATION
- Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease
- (2016) Pamela V Martino Adami et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad
- (2016) Konrad Kleszczyński et al. JOURNAL OF PINEAL RESEARCH
- Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells
- (2016) Yumin Wang et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain
- (2016) Silvia Fossati et al. NEUROBIOLOGY OF DISEASE
- Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid
- (2016) Krysti Todd et al. NEUROBIOLOGY OF DISEASE
- Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice
- (2016) Mingchang Li et al. Scientific Reports
- Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling
- (2015) Yan Hong et al. ARCHIVES OF PHARMACAL RESEARCH
- Clinical pharmacokinetics of melatonin: a systematic review
- (2015) Nathja Groth Harpsøe et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus
- (2015) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease
- (2015) Linjie Yu et al. LIFE SCIENCES
- Quantitative and antioxidative behavior of Trolox in rats’ blood and brain by HPLC-UV and SMFIA-CL methods
- (2015) Mitsuhiro Wada et al. LUMINESCENCE
- Polychlorinated Biphenyls Induce Mitochondrial Dysfunction in SH-SY5Y Neuroblastoma Cells
- (2015) Stefania Cocco et al. PLoS One
- Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid β Deposits and Peroxidation in Mice With Alzheimer-Like Lesions
- (2014) Rui Zhang et al. American Journal of Alzheimers Disease and Other Dementias
- Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration
- (2014) Krysti Todd et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
- (2014) Richard A. Harris et al. BIOGERONTOLOGY
- Brain PET in the Diagnosis of Alzheimer’s Disease
- (2014) Charles Marcus et al. CLINICAL NUCLEAR MEDICINE
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23Iowa mutation
- (2013) Silvia Fossati et al. BIOCHEMICAL JOURNAL
- Age-Related Mitochondrial Alterations without Neuronal Loss in the Hippocampus of a Transgenic Model of Alzheimer's Disease
- (2013) Mar Cuadrado-Tejedor et al. Current Alzheimer Research
- Mitochondria as a pharmacological target: Magnum overview
- (2013) Anna Olszewska et al. IUBMB LIFE
- NRF2-regulation in brain health and disease: Implication of cerebral inflammation
- (2013) Mats Sandberg et al. NEUROPHARMACOLOGY
- Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies
- (2013) Zhichun Chen et al. PROGRESS IN NEUROBIOLOGY
- Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke
- (2013) E M Messier et al. Cell Death & Disease
- Augmentation of Normal and Glutamate-Impaired Neuronal Respiratory Capacity by Exogenous Alternative Biofuels
- (2013) Melissa D. Laird et al. Translational Stroke Research
- Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
- (2013) K. M. Holmstrom et al. Biology Open
- Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
- (2013) Samantha Giordano et al. Redox Biology
- Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species
- (2012) Chu-Chiao Wu et al. ANTIOXIDANTS & REDOX SIGNALING
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease
- (2012) Eugenia Trushina et al. PLoS One
- Synaptic Mitochondrial Pathology in Alzheimer's Disease
- (2011) Heng Du et al. ANTIOXIDANTS & REDOX SIGNALING
- Assessing mitochondrial dysfunction in cells
- (2011) Martin D. Brand et al. BIOCHEMICAL JOURNAL
- Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
- (2011) P. Hemachandra Reddy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cellular and molecular effects of resveratrol in health and disease
- (2011) Wei Yu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease
- (2011) C. Perez-Cruz et al. JOURNAL OF NEUROSCIENCE
- Amyloid -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide
- (2011) T. Ma et al. JOURNAL OF NEUROSCIENCE
- Synaptic Autoregulation by Metalloproteases and -Secretase
- (2011) S. Restituito et al. JOURNAL OF NEUROSCIENCE
- Insights into Caspase-Mediated Apoptotic Pathways Induced by Amyloid-ß in Cerebral Microvascular Endothelial Cells
- (2011) Silvia Fossati et al. Neurodegenerative Diseases
- Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity
- (2011) M. Ionov et al. NEUROSCIENCE
- Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor proteinΞ
- (2011) R.A.S. Robinson et al. NEUROSCIENCE
- Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid
- (2011) Volker Nimmrich et al. REVIEWS IN THE NEUROSCIENCES
- Editorial [Hot topic: Melatonin and Brain (Guest Editor: Dun-Xian Tan)]
- (2010) Dun-Xian Tan Current Neuropharmacology
- Melatonin and Structurally-Related Compounds Protect Synaptosomal Membranes from Free Radical Damage
- (2010) Sergio Millán-Plano et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes
- (2010) Pil-Jae Kong et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
- (2010) Marcello D'Amelio et al. NATURE NEUROSCIENCE
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
- (2010) H. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration
- (2009) Ming-Jen Hsu et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Neuronal caspase-3 signaling: not only cell death
- (2009) M D'Amelio et al. CELL DEATH AND DIFFERENTIATION
- Cerebral amyloidosis: amyloid subunits, mutants and phenotypes
- (2009) A. Rostagno et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Aβ toxicity in human cerebral endothelial cells
- (2009) R. J. S. Viana et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls
- (2009) S. Fossati et al. FASEB JOURNAL
- Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
- (2009) Cristina Carvalho et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease
- (2009) James M. Olcese et al. JOURNAL OF PINEAL RESEARCH
- Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice
- (2009) Monica Garcia-Alloza et al. NEUROBIOLOGY OF AGING
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
- (2009) J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- (2009) V. Rhein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury
- (2009) Xin Wang et al. STROKE
- Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium
- (2008) Raffaella Solito et al. EXPERIMENTAL CELL RESEARCH
- Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
- (2008) Rosa Resende et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inhibitors of Cytochrome c Release with Therapeutic Potential for Huntington's Disease
- (2008) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes
- (2008) T. W. Fischer et al. JOURNAL OF PINEAL RESEARCH
- Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice
- (2008) Anne Eckert et al. Neurodegenerative Diseases
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