Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Brain arteriolosclerosis

(2020) Brittney L. Blevins et al.   ACTA NEUROPATHOLOGICA

Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients

(2020) Andrew Pearson et al.   BMC Neurology

Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma

(2020) Joseph Ojo et al.   NEUROBIOLOGY OF DISEASE

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?

(2019) Govindpani et al.   Journal of Clinical Medicine

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization

(2018) Lila Khennouf et al.   BRAIN

The Vascular Hypothesis of Alzheimer’s Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging

(2018) Jack de la Torre   JOURNAL OF ALZHEIMERS DISEASE

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Association Between the Apolipoprotein E Gene Polymorphism and Atherosclerotic Middle Cerebral Artery Stenosis

(2018) Zhengsheng Zhang et al.   NEUROLOGIST

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

(2018) David C. Hondius et al.   Acta Neuropathologica Communications

Neuropathology and Amyloid-β Spectrum in a Bapineuzumab Immunotherapy Recipient

(2018) Alex E. Roher et al.   JOURNAL OF ALZHEIMERS DISEASE

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

Endothelial cells promote excitatory synaptogenesis and improve ischemia-induced motor deficits in neonatal mice

(2018) Kun-Wei Wu et al.   NEUROBIOLOGY OF DISEASE

Associations between APOE genotype and cerebral small-vessel disease: a longitudinal study

(2017) Xiao Luo et al.   Oncotarget

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

(2016) Chelsea C. Hays et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Proteomic differences in brain vessels of Alzheimer’s disease mice: Normalization by PPARγ agonist pioglitazone

(2016) AmanPreet Badhwar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy

(2016) A. Manousopoulou et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Cerebral perfusion in the predementia stages of Alzheimer’s disease

(2015) Maja A. A. Binnewijzend et al.   EUROPEAN RADIOLOGY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

(2015) Luigi Yuri Di Marco et al.   NEUROBIOLOGY OF DISEASE

Cardiovascular risk factors and future risk of Alzheimer’s disease

(2014) Renée FAG de Bruijn et al.   BMC Medicine

Vascular risk factors and Alzheimer’s disease

(2014) John T O’Brien et al.   BMC Medicine

The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease

(2014) Angela Hanson et al.   CURRENT PHARMACEUTICAL DESIGN

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

(2013) Janna H. Neltner et al.   BRAIN

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

(2013) S. Schilling et al.   NEUROLOGY

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Disease in 2020

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

(2012) M. Yarchoan et al.   BRAIN

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

The capillary dysfunction hypothesis of Alzheimer's disease

(2012) Leif Østergaard et al.   NEUROBIOLOGY OF AGING

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

(2011) Donna M Wilcock et al.   Journal of Neuroinflammation

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

(2010) Dara L. Dickstein et al.   MOUNT SINAI JOURNAL OF MEDICINE

The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

(2010) Jack C. de la Torre   Neurodegenerative Diseases

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice

(2009) Donna Wilcock et al.   CNS & Neurological Disorders-Drug Targets

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Proteomics of Human Neurodegenerative Diseases

(2008) Jing Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease

(2008) John E. Donahue et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

(2008) Sabrina Utter et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition

(2008) Patrick M. Sullivan et al.   Journal of Stroke & Cerebrovascular Diseases