Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes

(2020) Giang T. H. Nguyen et al.   ANALYTICAL CHEMISTRY

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

(2020) Melissa D’Ascenzio et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

(2020) Paul C. McDonald et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors

(2020) Davide Moi et al.   BIOORGANIC CHEMISTRY

Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery

(2020) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

(2020) Valerio Ciccone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Carbonic Anhydrase IX inhibitors on human endothelial cell survival

(2020) Shirley Genah et al.   PHARMACOLOGICAL RESEARCH

Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors

(2020) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates hypoxia‐induced expression of CAIX and stem‐like breast cancer cell survival

(2020) Mira Kreuzer et al.   FEBS LETTERS

CAIX-Mediated Control of LIN28/let-7 Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

(2020) Adriana Gibadulinova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

(2020) Chandra B. Mishra et al.   MEDICINAL RESEARCH REVIEWS

How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH

(2020) Shen-Han Lee et al.   Cancers

A comparative study of the binding modes of SLC-0111 and its analogues in the hCA II and hCA IX active sites using QM/MM, molecular docking, MM-GBSA and MD approaches

(2020) Varun Chahal et al.   BIOPHYSICAL CHEMISTRY

Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors

(2020) Bengt-Harald Jonsson et al.   BIOPHYSICAL JOURNAL

3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies

(2020) Abdulsalam A.M. Alkhaldi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

(2020) Abdeslem Bouzina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis

(2020) Mohamed A. Abdelrahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand–Protein Binding Affinities

(2019) Giang T. H. Nguyen et al.   ACS Central Science

Carbonic anhydrases are involved in mitochondrial biogenesis and control the production of lactate by human Sertoli cells

(2019) Raquel L. Bernardino et al.   FEBS Journal

Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells

(2019) Ji Young Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

(2019) Silvia Pastorekova et al.   CANCER AND METASTASIS REVIEWS

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

(2019) Paul C. McDonald et al.   GASTROENTEROLOGY

Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically

(2019) Shawn C Chafe et al.   Cancer Immunology Research

Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies

(2019) Mahmoud F. Abo-Ashour et al.   BIOORGANIC CHEMISTRY

Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery

(2019) Alessio Nocentini et al.   Expert Opinion on Drug Discovery

The management of glaucoma and macular degeneration

(2019) Claudiu T Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation

(2019) Davide Moi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibition and the management of glaucoma: a literature and patent review 2013-2019

(2019) Claudiu T. Supuran et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Mechanism for the Binding of Netropsin to Hairpin DNA Revealed Using Nanoscale Ion Emitters in Native Mass Spectrometry

(2019) Giang T. H. Nguyen et al.   ANALYTICAL CHEMISTRY

Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors

(2019) Damiano Tanini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase IX is a critical determinant of pulmonary microvascular endothelial cell pH regulation and angiogenesis during acidosis

(2018) Ji Young Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Synthesis and biological evaluation of novel N , N ′-diaryl cyanoguanidines acting as potent and selective carbonic anhydrase II inhibitors

(2018) Suleyman Akocak et al.   BIOORGANIC CHEMISTRY

Design and synthesis of novel 1,3-diaryltriazene-substituted sulfonamides as potent and selective carbonic anhydrase II inhibitors

(2018) Nabih Lolak et al.   BIOORGANIC CHEMISTRY

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

(2018) Nicholas Favalli et al.   ChemMedChem

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

(2018) Laura De Luca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

(2018) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

(2018) Murat Bozdag et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

(2018) Claudiu T. Supuran et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity

(2018) Anne Riemann et al.   ONCOLOGY RESEARCH

Cancer radiotheranostics targeting carbonic anhydrase-IX with 111In- and 90Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy

(2018) Shimpei Iikuni et al.   Theranostics

pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma

(2018) Olga Kuchuk et al.   OncoImmunology

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

(2018) Shen-Han Lee et al.   BRITISH JOURNAL OF CANCER

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

(2018) Giuseppina De Simone et al.   CHEMICAL COMMUNICATIONS

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas

(2018) Claudiu T. Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

(2018) Alessio Nocentini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Systems analysis of intracellular pH vulnerabilities for cancer therapy

(2018) Erez Persi et al.   Nature Communications

Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide‐Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors

(2018) Alessio Nocentini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX

(2018) Wagdy M. Eldehna et al.   BIOORGANIC CHEMISTRY

Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides

(2017) Mam Y. Mboge et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer

(2017) Jennifer L Bryant et al.   INTERNATIONAL JOURNAL OF CANCER

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

(2017) Aleksandrs Pustenko et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

(2017) Silvia Bua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action

(2017) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

(2017) Elena Andreucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion

(2017) M Swayampakula et al.   ONCOGENE

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors

(2017) Andrea Angeli et al.   ACS Medicinal Chemistry Letters

Structure and function of carbonic anhydrases

(2016) C. T. Supuran   BIOCHEMICAL JOURNAL

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111

(2016) Carrie L. Lomelino et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

(2016) Vincenzo Alterio et al.   CHEMICAL COMMUNICATIONS

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Metabolism & Toxicology

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

(2016) Cristina Federici et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C

(2016) Prashant Mujumdar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma

(2016) Daniela Vullo et al.   JOURNAL OF MEDICINAL CHEMISTRY

PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas

(2016) Suleyman Akocak et al.   JOURNAL OF MEDICINAL CHEMISTRY

A 99mTc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo

(2016) N. Krall et al.   JOURNAL OF NUCLEAR MEDICINE

Regulation of HIF1  under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models

(2016) D. P. Logsdon et al.   MOLECULAR CANCER THERAPEUTICS

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

(2016) Anastasia Karioti et al.   MOLECULES

Carbonic anhydrase inhibition and the management of neuropathic pain

(2016) Claudiu T. Supuran   Expert Review of Neurotherapeutics

Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action

(2015) Aiga Grandane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity

(2015) Cenzo Congiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Out of the active site binding pocket for carbonic anhydrase inhibitors

(2015) Katia D'Ambrosio et al.   CHEMICAL COMMUNICATIONS

A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases

(2015) Emma Langella et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dual-pharmacophore DNA-encoded chemical libraries

(2015) Jörg Scheuermann et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure–Activity Relationships of Glucosyl-Based Sulfamates

(2015) Brian P. Mahon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors

(2015) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

(2015) Marta Ferraroni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

(2014) Erik O. Pettersen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors

(2013) Vincenzo Alterio et al.   BIOPOLYMERS

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

(2013) Giuseppina De Simone et al.   Expert Opinion on Drug Discovery

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture

(2013) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

(2013) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

(2013) Jérome Doyen et al.   Frontiers in Oncology

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development

(2012) Ewa S. Pilka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

(2012) Mayank Aggarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors

(2012) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Secondary and tertiary sulfonamides: a patent review (2008 – 2012)

(2012) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sulfonamides: a patent review (2008 – 2012)

(2012) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-based drug discovery of carbonic anhydrase inhibitors

(2012) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts

(2012) Roben G. Gieling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Co(II)-substituted Haemophilus influenzae β-carbonic anhydrase: Spectral evidence for allosteric regulation by pH and bicarbonate ion

(2011) Katherine M. Hoffmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

(2011) Shyamasri Biswas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Promiscuity of Carbonic Anhydrase II. Unexpected Ester Hydrolysis of Carbohydrate-Based Sulfamate Inhibitors

(2011) Marie Lopez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

(2010) Jason Wagner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

(2010) Anna Di Fiore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

(2010) Balendu Sankara Avvaru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

(2009) Julia K.J. Ahlskog et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

(2009) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase

(2009) Bradley T. Loughrey et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

(2009) Peter Ebbesen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitors. Comparison of Chlorthalidone and Indapamide X-ray Crystal Structures in Adducts with Isozyme II: When Three Water Molecules and the Keto−Enol Tautomerism Make the Difference†

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

(2008) Esra Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I–XIV with a series of substituted phenols including paracetamol and salicylic acid

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV)

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide–isozyme II adduct

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

(2008) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

(2008) Anna Di Fiore et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies

(2007) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS