Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

(2019) Xiaowei Li et al.   Frontiers in Psychiatry

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Aging and ischemic stroke

(2019) Mohammed Yousufuddin et al.   Aging-US

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome

(2019) Eloise Lemarchand et al.   STROKE

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

(2019) Pu Hong et al.   Journal of Neuroinflammation

Aging alters the immunological response to ischemic stroke

(2018) Rodney M. Ritzel et al.   ACTA NEUROPATHOLOGICA

Innate Immunity and Neurodegeneration

(2018) Larisa I. Labzin et al.   Annual Review of Medicine

Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment

(2018) Zhiliang Guo et al.   BRAIN RESEARCH BULLETIN

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

(2018) Nasimudeen R. Jabir et al.   CNS Neuroscience & Therapeutics

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice

(2018) Jie Feng et al.   CNS Neuroscience & Therapeutics

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2018) William J. Powers et al.   STROKE

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

The delta-opioid receptor and Parkinson’s disease

(2018) Jin-Zhong Huang et al.   CNS Neuroscience & Therapeutics

Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases

(2018) Bo-Zong Shao et al.   Frontiers in Molecular Neuroscience

Contribution of the inflammasome to inflammaging

(2018) Nancy H. Mejias et al.   Journal of Inflammation-London

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

(2017) Jill H Fowler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

(2017) J Scott Miners et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Imaging microglial activation and amyloid burden in amnestic mild cognitive impairment

(2017) Dunja Knezevic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing

(2017) Thomas Mandrup-Poulsen   Nature Reviews Endocrinology

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

(2017) Dongsheng Li et al.   Human Cell

NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases

(2016) Jin Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus

(2016) Yujun Wang et al.   BEHAVIOURAL BRAIN RESEARCH

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo

(2016) Kai-Chih Hung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammatory Response in the CNS: Friend or Foe?

(2016) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria

(2016) Jie Qu et al.   Oxidative Medicine and Cellular Longevity

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

MitomiRs in human inflamm-aging: A hypothesis involving miR-181a, miR-34a and miR-146a

(2014) Maria Rita Rippo et al.   EXPERIMENTAL GERONTOLOGY

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

(2013) Laurent L'homme et al.   JOURNAL OF LIPID RESEARCH

Physiology: Inflammation links ageing to the brain

(2013) Dana Gabuzda et al.   NATURE

Transmitting senescence to the cell neighbourhood

(2013) Matthew Hoare et al.   NATURE CELL BIOLOGY

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

(2012) Catherine Diane Savage et al.   Frontiers in Immunology

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

(2011) Lana J Mawhinney et al.   BMC NEUROSCIENCE

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Influence of Age and Health Behaviors on Stroke Risk: Lessons from Longitudinal Studies

(2010) Margaret Kelly-Hayes   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ac-YVAD-CMK Decreases Blood–Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model

(2009) Bihua Wu et al.   Translational Stroke Research

Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain

(2008) M. C. Déniz-Naranjo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE