Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
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Title
Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
Authors
Keywords
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Journal
LIVER INTERNATIONAL
Volume 36, Issue 11, Pages 1563-1579
Publisher
Wiley
Online
2016-06-09
DOI
10.1111/liv.13185
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Note: Only part of the references are listed.- The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
- (2016) Rosellina Margherita Mancina et al. GASTROENTEROLOGY
- The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage
- (2016) Benedetta Donati et al. HEPATOLOGY
- Inactivation ofTm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
- (2016) Eriks Smagris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis
- (2016) Stefano Ballestri et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- Genetics of nonalcoholic fatty liver disease
- (2016) Paola Dongiovanni et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
- (2016) KyeongJin Kim et al. Nature Communications
- Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis
- (2015) Ravi V. Shah et al. ATHEROSCLEROSIS
- Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes
- (2015) Hajime Yamazaki et al. DIABETES CARE
- Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups
- (2015) Amedeo Lonardo et al. DIGESTIVE AND LIVER DISEASE
- The dual and opposite role of theTM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis
- (2015) Carlos J. Pirola et al. HEPATOLOGY
- Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
- (2015) Paola Dongiovanni et al. HEPATOLOGY
- Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes
- (2015) Joshua R. Cook et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Non-alcoholic fatty liver disease predicts type 2 diabetes mellitus, but not prediabetes, in Xi'an, China: a five-year cohort study
- (2015) Jie Ming et al. LIVER INTERNATIONAL
- The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals
- (2015) Takuya Fukuda et al. LIVER INTERNATIONAL
- Comparison of effects of obesity and non-alcoholic fatty liver disease on incidence of type 2 diabetes mellitus
- (2015) Wei-Dong Li WORLD JOURNAL OF GASTROENTEROLOGY
- Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis
- (2015) Paola Dongiovanni et al. Biomed Research International
- Turning Off AKT: PHLPP as a Drug Target
- (2014) Alexandra C. Newton et al. Annual Review of Pharmacology and Toxicology
- CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance
- (2014) Suryaprakash Raichur et al. Cell Metabolism
- PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
- (2014) Andreas Peter et al. DIABETOLOGIA
- PHLPP Is a Negative Regulator of RAF1, Which Reduces Colorectal Cancer Cell Motility and Prevents Tumor Progression in Mice
- (2014) Xin Li et al. GASTROENTEROLOGY
- Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
- (2014) Eriks Smagris et al. HEPATOLOGY
- PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
- (2014) Carlo Pirazzi et al. HUMAN MOLECULAR GENETICS
- Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) and PH Domain and Leucine-rich Repeat Phosphatase Cross-talk (PHLPP) in Cancer Cells and in Transforming Growth Factor β-Activated Stem Cells
- (2014) Aram Ghalali et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia
- (2014) Mathilde Di Filippo et al. JOURNAL OF HEPATOLOGY
- PNPLA3 mediates hepatocyte triacylglycerol remodeling
- (2014) Hanna Ruhanen et al. JOURNAL OF LIPID RESEARCH
- β-Cell function in type 2 diabetes
- (2014) Ele Ferrannini et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt
- (2014) Pingping Wang et al. MOLECULAR CELL
- Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
- (2014) Oddgeir L Holmen et al. NATURE GENETICS
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
- (2014) Gerald I. Shulman NEW ENGLAND JOURNAL OF MEDICINE
- Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease
- (2014) Salvatore Petta et al. PLoS One
- TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
- (2014) H. Mahdessian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors
- (2014) Paola Dongiovanni WORLD JOURNAL OF GASTROENTEROLOGY
- Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
- (2014) Rebecca A. Haeusler et al. Nature Communications
- Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
- (2014) Hannele Yki-Järvinen Lancet Diabetes & Endocrinology
- Cohort Study of Non-alcoholic Fatty Liver Disease, NAFLD fibrosis score and the Risk of Incident Diabetes in a Korean population
- (2013) Yoosoo Chang et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Increased Risk of Type 2 Diabetes in Subjects with Both Elevated Liver Enzymes and Ultrasonographically Diagnosed Nonalcoholic Fatty Liver Disease: A 4-year Longitudinal Study
- (2013) Ji Hun Choi et al. ARCHIVES OF MEDICAL RESEARCH
- A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia
- (2013) Angelo B. Cefalù et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice
- (2013) Frédéric De Ceuninck et al. BRITISH JOURNAL OF PHARMACOLOGY
- Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
- (2013) L. Valenti et al. DIABETES
- Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity
- (2013) J. Hyysalo et al. DIABETES
- Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver
- (2013) R. Lehmann et al. DIABETES CARE
- Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
- (2013) Matej Orešič et al. DIABETOLOGIA
- Resolution of Fatty Liver and Risk of Incident Diabetes
- (2013) Ki-Chul Sung et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team
- (2013) Jessica Dyson et al. JOURNAL OF HEPATOLOGY
- Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
- (2013) Utpal B Pajvani et al. NATURE MEDICINE
- SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice
- (2013) Lei Li et al. PLoS One
- PNPLA3 I148M polymorphism and progressive liver disease
- (2013) Paola Dongiovanni WORLD JOURNAL OF GASTROENTEROLOGY
- Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
- (2013) Melania Gaggini et al. Nutrients
- Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans
- (2012) Frédéric De Ceuninck et al. BRITISH JOURNAL OF PHARMACOLOGY
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression
- (2012) Joel T. Haas et al. Cell Metabolism
- Combined Influence of Insulin Resistance, Overweight/Obesity, and Fatty Liver as Risk Factors for Type 2 Diabetes
- (2012) K.-C. Sung et al. DIABETES CARE
- Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms
- (2012) Luca Valenti et al. HEPATOLOGY
- Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5-year prospective cohort study
- (2012) Sung Keun Park et al. HEPATOLOGY
- Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects
- (2012) R Rametta et al. INTERNATIONAL JOURNAL OF OBESITY
- Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus
- (2012) Anuradhani Kasturiratne et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
- (2012) Mingjian Lu et al. NATURE MEDICINE
- Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant
- (2012) Colin N. A. Palmer et al. PLoS One
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- Hormonal Regulation of Hepatic Glucose Production in Health and Disease
- (2011) Hua V. Lin et al. Cell Metabolism
- Combined Effect of Nonalcoholic Fatty Liver Disease and Impaired Fasting Glucose on the Development of Type 2 Diabetes: A 4-year retrospective longitudinal study
- (2011) J. C. Bae et al. DIABETES CARE
- Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus
- (2011) Amalia Gastaldelli DIABETES RESEARCH AND CLINICAL PRACTICE
- Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice
- (2011) Kebin Zhang et al. ENDOCRINOLOGY
- Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States
- (2011) Michael R. Charlton et al. GASTROENTEROLOGY
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
- (2011) Nicola Santoro et al. HEPATOLOGY
- Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
- (2011) Silvia Sookoian et al. HEPATOLOGY
- Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene
- (2011) Rongya Tao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hepatic Glucokinase Expression Is Associated with Lipogenesis and Fatty Liver in Humans
- (2011) Andreas Peter et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- NASH animal models: Are we there yet?
- (2011) Rohit Kohli et al. JOURNAL OF HEPATOLOGY
- Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
- (2011) Utpal B Pajvani et al. NATURE MEDICINE
- Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
- (2011) N. Kumashiro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance
- (2010) David B Savage et al. CURRENT OPINION IN LIPIDOLOGY
- Dissociation Between Intrahepatic Triglyceride Content and Insulin Resistance in Familial Hypobetalipoproteinemia
- (2010) Anastassia Amaro et al. GASTROENTEROLOGY
- Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
- (2010) Diego F. Calvisi et al. GASTROENTEROLOGY
- Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease
- (2010) P. Dongiovanni et al. GUT
- Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis
- (2010) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
- (2010) William L Holland et al. NATURE MEDICINE
- Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
- (2010) Giovanni Targher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
- (2010) Shijie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
- (2009) Karla F. Leavens et al. Cell Metabolism
- From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
- (2009) R. A. DeFronzo DIABETES
- The role of the lipogenic pathway in the development of hepatic steatosis
- (2009) C. Postic et al. DIABETES & METABOLISM
- Adipokines in liver diseases
- (2009) Fabio Marra et al. HEPATOLOGY
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia
- (2009) Hui-Yu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
- (2009) Shaoqing He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup
- (2009) Tamaki Yamada et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis
- (2009) S. Guo et al. MOLECULAR AND CELLULAR BIOLOGY
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
- (2009) E. Fabbrini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New Insights into mTOR Signaling: mTORC2 and Beyond
- (2009) D. R. Alessi et al. Science Signaling
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- TheDGAT2gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
- (2008) Konstantinos Kantartzis et al. CLINICAL SCIENCE
- Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis
- (2008) L. Valenti et al. DIABETES
- Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults
- (2008) C.-H. Kim et al. DIABETIC MEDICINE
- Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
- (2008) Mary E. Rinella et al. JOURNAL OF LIPID RESEARCH
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
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