Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis

(2016) Joan Mir-Coll et al.   DIABETOLOGIA

Role of glycogen metabolism in pancreatic islet beta cell function

(2016) Willy J. Malaisse   DIABETOLOGIA

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes

(2016) Tarig Babiker et al.   DIABETOLOGIA

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes

(2015) Brian W. Thurber et al.   DIABETOLOGIA

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease

(2014) J. Duran et al.   HUMAN MOLECULAR GENETICS

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Glycogen and its metabolism: some new developments and old themes

(2012) Peter J. Roach et al.   BIOCHEMICAL JOURNAL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Deleterious effects of neuronal accumulation of glycogen in flies and mice

(2012) Jordi Duran et al.   EMBO Molecular Medicine

In-depth annotation of SNPs arising from resequencing projects using NGS-SNP

(2011) J. R. Grant et al.   BIOINFORMATICS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Defects in beta cell Ca2+ signalling, glucose metabolism and insulin secretion in a murine model of KATP channel-induced neonatal diabetes mellitus

(2011) R. K. P. Benninger et al.   DIABETOLOGIA

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Role of autophagy in β-cell function and mass

(2010) K. Y. Hur et al.   DIABETES OBESITY & METABOLISM

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic  -Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of  -Cell Function

(2008) M. Kebede et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Physicochemical changes in phosphorylase kinase associated with its activation

(2008) Weiya Liu et al.   PROTEIN SCIENCE