High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study

(2009) Clare N. Gallagher et al.   BRAIN

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease

(2009) D. Galter et al.   GENES BRAIN AND BEHAVIOR

Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

(2009) Fawzi Boumezbeur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats

(2009) Xianrong Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Lactate fuels the human brain during exercise

(2008) Bjørn Quistorff et al.   FASEB JOURNAL

Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte-Neuron Lactate-Shuttle Hypothesis

(2008) J. S. Erlichman et al.   JOURNAL OF NEUROSCIENCE

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

(2008) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING

Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles

(2008) Takeshi Hashimoto et al.   PLoS One