Nuclear DNA damage signalling to mitochondria in ageing

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

P53 and aging: A fresh look at an old paradigm

(2016) Masha V. Poyurovsky et al.   Aging-US

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging

(2016) Morten Scheibye-Knudsen et al.   Aging-US

Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

(2016) Scott Maynard et al.   Aging-US

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Mitochondrial DNA Variation in Human Radiation and Disease

(2015) Douglas C. Wallace   CELL

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

(2015) Lin Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel method for determining humanex vivosubmaximal skeletal muscle mitochondrial function

(2015) Martin Hey-Mogensen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Protecting the mitochondrial powerhouse

(2015) Morten Scheibye-Knudsen et al.   TRENDS IN CELL BIOLOGY

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

(2015) Shivani Malik et al.   Scientific Reports

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

(2015) Shrestha Ghosh et al.   Cell Reports

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

(2014) Morten Scheibye-Knudsen et al.   Autophagy

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress

(2014) G. Saretzki   CURRENT PHARMACEUTICAL DESIGN

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging

(2014) Namgyu Lee et al.   PROTEOMICS

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

(2013) Amrita Madabushi et al.   BIOCHEMICAL JOURNAL

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Body Mass Index, Change in Body Mass Index, and Survival in Old and Very Old Persons

(2013) Anna K. Dahl et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

A Putative Antiaging Drug Takes a Step From Mice to Men

(2013) M. Leslie   SCIENCE

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

(2012) Deborah L. Croteau et al.   AGING CELL

Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition

(2012) Xiaolei Xie et al.   Autophagy

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

(2012) Shouqing Luo et al.   MOLECULAR CELL

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells

(2012) Maria Maryanovich et al.   NATURE CELL BIOLOGY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

(2012) Aswin Mangerich et al.   Oxidative Medicine and Cellular Longevity

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Common toxicities of mammalian target of rapamycin inhibitors

(2011) Scott A. Soefje et al.   Targeted Oncology

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

Role of SIRT1 in homologous recombination

(2010) Miriam Uhl et al.   DNA REPAIR

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

(2009) James E. Cleaver et al.   NATURE REVIEWS GENETICS

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease

(2008) Pal Pacher et al.   AMERICAN JOURNAL OF PATHOLOGY

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY