Calorie restriction as an intervention in ageing

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Hormesis, cell death and aging

(2016) Isabelle Martins et al.   Aging-US

Will calorie restriction work in humans?

(2016) Edda Cava et al.   Aging-US

Age-associated miRNA Alterations in Skeletal Muscle from Rhesus Monkeys reversed by caloric restriction

(2016) Evi M. Mercken et al.   Aging-US

Quality control systems in cardiac aging

(2015) Ellen K. Quarles et al.   AGEING RESEARCH REVIEWS

DAMPs as mediators of sterile inflammation in aging-related pathologies

(2015) Noa Feldman et al.   AGEING RESEARCH REVIEWS

The Interplay Between Respiratory Supercomplexes and ROS in Aging

(2015) Maria Luisa Genova et al.   ANTIOXIDANTS & REDOX SIGNALING

Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1–AMPK–mTOR pathway

(2015) Guo-hua Li et al.   ATHEROSCLEROSIS

Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients

(2015) Elísabet Alcocer-Gómez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-inflammatory effect of resveratrol in old mice liver

(2015) Bui Thanh Tung et al.   EXPERIMENTAL GERONTOLOGY

Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

(2015) Elisa Fabbri et al.   Journal of the American Medical Directors Association

Reconsidering the Role of Mitochondria in Aging

(2015) Marta Gonzalez-Freire et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MARK-AGE biomarkers of ageing

(2015) Alexander Bürkle et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD

(2015) Josef Brandauer et al.   Frontiers in Physiology

The influence of systemic inflammation on skeletal muscle in physically active elderly women

(2014) Britta Wåhlin-Larsson et al.   AGE

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Physical activity affects plasma coenzyme Q10 levels differently in young and old humans

(2014) Jesús Del Pozo-Cruz et al.   BIOGERONTOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Inflammation, ageing and chronic disease

(2014) Graham Pawelec et al.   CURRENT OPINION IN IMMUNOLOGY

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

(2014) Gabriella Testa et al.   CURRENT PHARMACEUTICAL DESIGN

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

(2014) Husam Khraiwesh et al.   EXPERIMENTAL GERONTOLOGY

Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people

(2014) Jesús Del Pozo-Cruz et al.   EXPERIMENTAL GERONTOLOGY

Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging

(2014) Shaday Michan   Frontiers in Bioscience-Landmark

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

(2014) José A. López-Domínguez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age-Dependent Effect of Every-Other-Day Feeding and Aerobic Exercise in Ubiquinone Levels and Related Antioxidant Activities in Mice Muscle

(2014) Elizabeth Rodríguez-Bies et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans

(2014) Gilles Gouspillou et al.   PLoS One

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity inCaenorhabditis elegans

(2014) Ara B. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

(2014) Dimitry A. Chistiakov et al.   Biomed Research International

Aging Is Not a Disease: Implications for Intervention

(2014) Suresh Rattan   Aging and Disease

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

(2013) Lin Yan et al.   AGE

What are the roles of calorie restriction and diet quality in promoting healthy longevity?

(2013) Wanda Rizza et al.   AGEING RESEARCH REVIEWS

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Energy requirements in nonobese men and women: results from CALERIE

(2013) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

(2013) Sarah Sczelecki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation

(2013) Jesper Olesen et al.   EXPERIMENTAL GERONTOLOGY

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Caloric Restriction

(2013) Connie W. Bales et al.   Journal of Cardiopulmonary Rehabilitation and Prevention

Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats

(2013) H. Khraiwesh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A holidic medium for Drosophila melanogaster

(2013) Matthew D W Piper et al.   NATURE METHODS

Mitochondrial Function in Human Neuroblastoma Cells Is Up-Regulated and Protected by NQO1, a Plasma Membrane Redox Enzyme

(2013) Jiyeong Kim et al.   PLoS One

Resveratrol Up-Regulates the Erythrocyte Plasma Membrane Redox System and Mitigates Oxidation-Induced Alterations in Erythrocytes During Aging in Humans

(2013) Kanti Bhooshan Pandey et al.   REJUVENATION RESEARCH

Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1

(2013) Seung-Hoon Yeo et al.   TOXICOLOGY LETTERS

Calorie-restriction and longevity. End of a dream, at least for primates?

(2013) L. Robert   European Geriatric Medicine

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice

(2012) José Alberto López-Domínguez et al.   AGE

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction

(2012) Alejandro Martin-Montalvo et al.   ANTIOXIDANTS & REDOX SIGNALING

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction

(2012) Yana Chen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress

(2011) Dong-Hoon Hyun et al.   AGE

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

(2011) Benjamin F. Miller et al.   AGING CELL

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1

(2011) Joshua P. Gray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle

(2011) Ling Li et al.   BASIC RESEARCH IN CARDIOLOGY

Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells

(2011) Nae-Cherng Yang et al.   BIOGERONTOLOGY

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

(2011) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

(2011) H.Y. Chung et al.   JOURNAL OF DENTAL RESEARCH

Erythrocyte plasma membrane redox system may determine maximum life span

(2011) Syed Ibrahim Rizvi et al.   MEDICAL HYPOTHESES

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

(2011) Qilong Wang et al.   PLoS One

Age-associated development of inflammation in Wistar rats: Effects of caloric restriction

(2011) Daniel Horrillo et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Predicting whether dietary restriction would increase longevity in species not tested so far

(2010) Éric Le Bourg   AGEING RESEARCH REVIEWS

A critical role of SNF1A/dAMPKα (Drosophila AMP-activated protein kinase α) in muscle on longevity and stress resistance in Drosophila melanogaster

(2010) Daisuke Tohyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Aging and TOR: interwoven in the fabric of life

(2010) Zelton Dave Sharp   CELLULAR AND MOLECULAR LIFE SCIENCES

Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

(2010) G. Candore et al.   CURRENT PHARMACEUTICAL DESIGN

Impaired quality control of mitochondria: Aging from a new perspective

(2010) Tobias A. Weber et al.   EXPERIMENTAL GERONTOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Glycolytic inhibition as a strategy for developing calorie restriction mimetics

(2010) Donald K. Ingram et al.   EXPERIMENTAL GERONTOLOGY

Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle

(2010) Susan H. McKiernan et al.   EXPERIMENTAL GERONTOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acetate metabolism and aging: An emerging connection

(2010) Tadahiro Shimazu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Muscle Physiology Changes Induced by Every Other Day Feeding and Endurance Exercise in Mice: Effects on Physical Performance

(2010) Elizabeth Rodríguez-Bies et al.   PLoS One

Dietary Restriction: Standing Up for Sirtuins

(2010) J. A. Baur et al.   SCIENCE

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

(2009) María Jiménez-Hidalgo et al.   AGING CELL

Invertebrate models of age-related muscle degeneration

(2009) Hrvoje Augustin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae

(2009) Alaric A. Falcón et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The role of systemic inflammation in age-related muscle weakness and wasting

(2009) H. Degens   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats

(2009) Robin K. Minor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Ongoing Saga of Sirtuins and Aging

(2008) Matt Kaeberlein   Cell Metabolism

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

(2008) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary factors, hormesis and health

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

Hormesis in aging

(2007) Suresh I.S. Rattan   AGEING RESEARCH REVIEWS

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL