New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

(2012) Z. Wang et al.   GENES & DEVELOPMENT

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

(2011) Noam Levaot et al.   CELL

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

(2011) Sebastian Guettler et al.   CELL

The Poly(ADP-ribose) polymerases (PARPs): New roles in intracellular transport

(2011) Zakaria Y. Abd Elmageed et al.   CELLULAR SIGNALLING

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

PARP inhibitors in cancer: moving beyond BRCA

(2011) Melinda L Telli   LANCET ONCOLOGY

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70

(2011) Steven J. Petesch et al.   MOLECULAR CELL

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin

(2011) E. Kotova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

(2011) C. Boehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

A review of PARP inhibitors: from bench to bedside

(2010) C. Underhill et al.   ANNALS OF ONCOLOGY

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

The roles of PARP1 in gene control and cell differentiation

(2010) Yingbiao Ji et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes

(2010) Hyunju Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA

(2010) Olga Loseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

(2010) G.-Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications

(2010) Rupinder K. Sodhi et al.   VASCULAR PHARMACOLOGY

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

(2009) Nadine Martin et al.   EMBO JOURNAL

Structural and Biophysical Studies of Human PARP-1 in Complex with Damaged DNA

(2009) Wayne Lilyestrom et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly

(2009) Paul Chang et al.   MOLECULAR BIOLOGY OF THE CELL

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

(2009) Matthias Altmeyer et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

Poly (ADP-Ribose) Polymerase 1 Is Required for Protein Localization to Cajal Body

(2009) Elena Kotova et al.   PLoS Genetics

Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci

(2008) Steven J. Petesch et al.   CELL

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation

(2008) Henning Kleine et al.   MOLECULAR CELL

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

The Nucleosome-Remodeling ATPase ISWI Is Regulated by Poly-ADP-Ribosylation

(2008) Anna Sala et al.   PLOS BIOLOGY

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark

Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides

(2007) Tao Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY