In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

(2020) Wayne Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial protein interaction landscape of SS-31

(2020) Juan D. Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitoprotection preserves the renal vasculature in porcine metabolic syndrome

(2018) Alfonso Eirin et al.   EXPERIMENTAL PHYSIOLOGY

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

(2018) Amel Karaa et al.   NEUROLOGY

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice

(2018) Matthew D. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise capacity and mortality – a follow-up study of 3033 subjects referred to clinical exercise testing

(2016) Raija Korpelainen et al.   ANNALS OF MEDICINE

Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods

(2016) Matthew D. Campbell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function

(2016) Adam J. Santanasto et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia

(2016) Terence E. Ryan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Association of Muscle Endurance, Fatigability, and Strength With Functional Limitation and Mortality in the Health Aging and Body Composition Study

(2016) Baback Roshanravan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging

(2016) Seongjin Choi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

(2016) Giorgos K. Sakellariou et al.   Scientific Reports

Reconsidering the Role of Mitochondria in Aging

(2015) Marta Gonzalez-Freire et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Comparative Associations of Muscle Mass and Muscle Strength with Mortality in Dialysis Patients

(2014) N. Isoyama et al.   Clinical Journal of the American Society of Nephrology

Bendavia, a Mitochondria-targeting Peptide, Improves Postinfarction Cardiac Function, Prevents Adverse Left Ventricular Remodeling, and Restores Mitochondria-related Gene Expression in Rats

(2014) Wangde Dai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

(2013) Michael P. Siegel et al.   AGING CELL

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

(2013) David A. Brown et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Association between Physical Performance and All-Cause Mortality in CKD

(2013) B. Roshanravan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults

(2012) Paul M. Coen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

(2012) Vincenzo Libri et al.   PLoS One

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Capacity of oxidative phosphorylation in human skeletal muscle

(2009) Erich Gnaiger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cardiolipin, the heart of mitochondrial metabolism

(2008) R. H. Houtkooper et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial function in vivo: Spectroscopy provides window on cellular energetics

(2008) Catherine E. Amara et al.   METHODS