Lon in maintaining mitochondrial and endoplasmic reticulum homeostasis

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

iTRAQ Mitoproteome Analysis Reveals Mechanisms of Programmed Cell Death in Arabidopsis thaliana Induced by Ochratoxin A

(2017) Yan Wang et al.   Toxins

The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1

(2016) Laura C. D. Pomatto et al.   BIOLOGICAL REVIEWS

Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders

(2016) Daniela A. Bota et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer

(2015) Marcello Pinti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR)

(2015) Assaf Bahat et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Lon regulates apoptosis through the association with Hsp60–mtHsp70 complex

(2015) T-Y Kao et al.   Cell Death & Disease

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA

(2014) Ayenachew Bezawork-Geleta et al.   FASEB JOURNAL

Central role of Nix in the autophagic response to ochratoxin A

(2014) Xiao Li Shen et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective role of the mitochondrial Lon protease 1 in ochratoxin A-induced cytotoxicity in HEK293 cells

(2014) Boyang Zhang et al.   Journal of Proteomics

Mitochondrial proteomic analysis reveals the molecular mechanisms underlying reproductive toxicity of zearalenone in MLTC-1 cells

(2014) Yuzhe Li et al.   TOXICOLOGY

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

(2014) Pedro M. Quirós et al.   Cell Reports

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

(2014) Ruth E. Thomas et al.   PLoS Genetics

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation

(2013) Assaf Bahat et al.   MOLECULAR ENDOCRINOLOGY

Oxygen-sensitive mitochondrial accumulation of cystathionine  -synthase mediated by Lon protease

(2013) H. Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling, and metabolism of reactive oxygen species

(2013) Oleh V. Lushchak et al.   REDOX REPORT

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

(2013) Cole M. Haynes et al.   TRENDS IN CELL BIOLOGY

Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species

(2013) C-W Cheng et al.   Cell Death & Disease

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diphenylarsinic Acid Promotes Degradation of Glutaminase C by Mitochondrial Lon Protease

(2012) Kayoko Kita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK 293 cells

(2012) Xiao Li Shen et al.   Journal of Proteomics

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

(2012) Bin Lu et al.   MOLECULAR CELL

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

(2012) Sebastián Bernales et al.   Frontiers in Aging Neuroscience

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Multitasking in the mitochondrion by the ATP-dependent Lon protease

(2011) Sundararajan Venkatesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes

(2011) Xu Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells

(2011) Qing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SnapShot: The Unfolded Protein Response

(2010) R. Luke Wiseman et al.   CELL

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

(2010) Sun-Shin Cha et al.   EMBO JOURNAL

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

(2010) Y. Matsushima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Lon protease is a human stress protein

(2009) Jenny K. Ngo et al.   FREE RADICAL BIOLOGY AND MEDICINE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA