A common signature of cellular senescence; does it exist?

Mitotic checkpoint defects: en route to cancer and drug resistance

(2021) Sinjini Sarkar et al.   CHROMOSOME RESEARCH

CELL CYCLE STRESS IN NORMAL HUMAN CELLS: A ROUTE TO “FIRST CELLS” (WITH/WITHOUT FITNESS GAIN) AND CANCER-LIKE CELL-SHAPE CHANGES

(2021) Kirsten H Walen   SEMINARS IN CANCER BIOLOGY

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

(2021) Mikolaj Ogrodnik   AGING CELL

Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy

(2021) Tomas L. White et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear localization of p65 reverses therapy induced senescence

(2021) Sameer Salunkhe et al.   JOURNAL OF CELL SCIENCE

Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging

(2021) Rashmi Upadhyay Pathak et al.   AGEING RESEARCH REVIEWS

Algorithmic assessment of cellular senescence in experimental and clinical specimens

(2021) J. Kohli et al.   Nature Protocols

Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response

(2021) Anna Strzeszewska-Potyrała et al.   Cancers

Dissecting primary and secondary senescence to enable new senotherapeutic strategies

(2021) Tesfahun Dessale Admasu et al.   AGEING RESEARCH REVIEWS

Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence

(2020) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

(2020) Emanuela Mensà et al.   Journal of Extracellular Vesicles

Nuclear envelope dysfunction and its contribution to the aging process

(2020) Filipa Martins et al.   AGING CELL

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional heterogeneity in senescence

(2020) Kristina Kirschner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres

(2020) Kristine Salmina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oncogene-induced senescence: From biology to therapy

(2020) Haoran Zhu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Long-lived post-mitotic cell aging: is a telomere clock at play?

(2020) Maria Sol Jacome-Burbano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Bright and Dark Side of Extracellular Vesicles in the Senescence-Associated Secretory Phenotype

(2020) Ryan Wallis et al.   MECHANISMS OF AGEING AND DEVELOPMENT

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

(2020) Satish Sati et al.   MOLECULAR CELL

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

(2020) Shuling Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Induction and transmission of oncogene-induced senescence

(2020) Nattaphong Rattanavirotkul et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A guide to assessing cellular senescence in vitro and in vivo

(2020) Estela González‐Gualda et al.   FEBS Journal

Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells

(2020) Agnieszka Bojko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells

(2020) Wioleta Grabowska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy

(2020) Piotr Sunderland et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts

(2020) Yiting Guan et al.   NUCLEIC ACIDS RESEARCH

Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch

(2020) Kotaro Fujimaki et al.   PHYSIOLOGICAL GENOMICS

Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors

(2020) Marie-Sophie Narzt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapy-induced polyploidization and senescence: Coincidence or interconnection?

(2020) Ewa Sikora et al.   SEMINARS IN CANCER BIOLOGY

Targeting tumor cell senescence and polyploidy as potential therapeutic strategies

(2020) Tareq Saleh et al.   SEMINARS IN CANCER BIOLOGY

Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells

(2020) Katarzyna Piszczatowska et al.   Antioxidants

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment

(2019) Jordan Guillon et al.   Cell Death & Disease

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Nuclear pore density controls heterochromatin reorganization during senescence

(2019) Charlene Boumendil et al.   GENES & DEVELOPMENT

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

A functional genetic screen defines the AKT-induced senescence signaling network

(2019) Keefe T. Chan et al.   CELL DEATH AND DIFFERENTIATION

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

The “life code”: a theory that unifies the human life cycle and the origin of human tumors

(2019) Liu Jinsong   SEMINARS IN CANCER BIOLOGY

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

(2019) Christopher D. Wiley et al.   Cell Reports

Targeting normal and cancer senescent cells as a strategy of senotherapy

(2019) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance

(2019) Deblina Bharadwaj et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

(2018) Lucia Terlecki-Zaniewicz et al.   Aging-US

Polyploidy in tissue homeostasis and regeneration

(2018) Jan Inge Øvrebø et al.   DEVELOPMENT

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

PTENdeletion in luminal cells of mature prostate induces replication stress and senescence in vivo

(2018) Maxime Parisotto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types

(2018) Anne Zirkel et al.   MOLECULAR CELL

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

(2018) Xuerong Sun et al.   Cell Death & Disease

Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells

(2018) Anna Strzeszewska et al.   Cell Death & Disease

Correction to: Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells

(2018) Natalia Pietrosemoli et al.   Skeletal Muscle

Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment

(2018) et al.   Cancers

Aging, Cell Senescence, and Chronic Disease

(2018) Tamara Tchkonia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

(2018) Maja Milanovic et al.   TRENDS IN CELL BIOLOGY

Persistent repair intermediates induce senescence

(2018) F. M. Feringa et al.   Nature Communications

A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling

(2018) Natalia Dworak et al.   AGING CELL

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Coaching from the sidelines: the nuclear periphery in genome regulation

(2018) Abigail Buchwalter et al.   NATURE REVIEWS GENETICS

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Massive reshaping of genome–nuclear lamina interactions during oncogene-induced senescence

(2017) Christelle Lenain et al.   GENOME RESEARCH

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells

(2017) E L Kavanagh et al.   Oncogenesis

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells

(2016) Rumi Arai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of lamin B receptor is necessary to induce cellular senescence

(2016) Emilie Lukášová et al.   BIOCHEMICAL JOURNAL

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Is Senescence Reversible?

(2016) Shweta Chakradeo et al.   CURRENT DRUG TARGETS

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

(2016) Chunya Ni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

(2016) Katherine M. Aird et al.   JOURNAL OF CELL BIOLOGY

Old cells, new tricks: chromatin structure in senescence

(2016) Aled John Parry et al.   MAMMALIAN GENOME

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Spatial organization of chromatin domains and compartments in single chromosomes

(2016) Siyuan Wang et al.   SCIENCE

The Chromatin Landscape of Cellular Senescence

(2016) Steven W. Criscione et al.   TRENDS IN GENETICS

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

NOX4 downregulation leads to senescence of human vascular smooth muscle cells

(2016) Dorota Przybylska et al.   Oncotarget

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

(2016) Halina Was et al.   Oncotarget

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Replicatively senescent cells are arrested in G1 and G2 phases

(2016) Zhiyong Mao et al.   Aging-US

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

(2015) Christelle Lenain et al.   CARCINOGENESIS

The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells

(2015) Luis Jaime Castro-Vega et al.   CARCINOGENESIS

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

(2015) Anda Huna et al.   CELL CYCLE

Senescence from G2 arrest, revisited

(2015) Véronique Gire et al.   CELL CYCLE

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

(2015) C Leikam et al.   Cell Death & Disease

Global Reorganization of the Nuclear Landscape in Senescent Cells

(2015) Tamir Chandra et al.   Cell Reports

Contribution of Topological Domains and Loop Formation to 3D Chromatin Organization

(2015) Vuthy Ea et al.   Genes

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

(2014) Lenno Krenning et al.   MOLECULAR CELL

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

Ki67 is a promising molecular target in the diagnosis of cancer (Review)

(2014) LIAN TAO LI et al.   Molecular Medicine Reports

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

(2013) Anna Bielak-Zmijewska et al.   BIOGERONTOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

(2013) Sabrina L. Spencer et al.   CELL

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

(2013) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

(2013) Alexandre Iannello et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells

(2012) Akiyuki Hirosue et al.   AGING CELL

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm

(2012) Rudolf Jaenisch   Cell Stem Cell

Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells

(2012) Z. Korwek et al.   DNA REPAIR

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells

(2012) J Cahu et al.   Cell Death & Disease

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models

(2011) Michal Sabisz et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

(2011) Tomasz Biliński et al.   FEMS YEAST RESEARCH

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Silencing Nuclear Pore Protein Tpr Elicits a Senescent-Like Phenotype in Cancer Cells

(2011) Brigitte David-Watine   PLoS One

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

A chemotherapy-associated senescence bystander effect in breast cancer cells

(2010) Xu Di et al.   CANCER BIOLOGY & THERAPY

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

(2010) J Bartkova et al.   ONCOGENE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

(2009) K. Gosselin et al.   CANCER RESEARCH

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

The evolution of haploidy and diploidy

(2008) Sarah P. Otto et al.   CURRENT BIOLOGY

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The metabolic syndrome, IGF-1, and insulin action

(2008) Yasumichi Arai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Structure, dynamics and function of nuclear pore complexes

(2008) Maximiliano A. D’Angelo et al.   TRENDS IN CELL BIOLOGY